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| 1 | 阅读词汇教学:从理论到实践显示文摘过去二十多年的研究增强了人们对词汇在阅读理解中重要作用的了解。然而,研究与实践常常相差甚远,并非所有的研究结果或理论都能直接为阅读教师所用。本文的目的是要展示笔者是如何将理论与研究应用到第二语言的阅读课词汇教学中,使基于理论的教学方法与理论统一连贯。笔者将首先阐述词汇在阅读理解中的重要作用。 | Khairi I.Abdullah 赵蔚 | 1995 | 外语教学理论与实践1995，，4： | 17 |
| 2 | 噬菌体在检测食源性病原菌中的应用研究进展显示文摘食源性病原菌是导致食源性疾病的主要原因之一,现代食品工业的迅猛发展对食品中病原菌的快速检测提出了更高的要求。噬菌体作为地球上种类最丰富的微生物之一,能够侵染细菌。研究表明,噬菌体不仅具备结构简单、特异性强、价格低廉等特性,而且具有能够区分活细菌和死细菌的能力,以及容易与其他传统检测方法相结合等优势,噬菌体及其产物为食源性病原菌的检测提供了新的思路。近年来,噬菌体与免疫学、分子生物学和纳米科学等学科结合形成的新型快速检测方法已成为国际研究热点。本文就噬菌体检测食源性病原菌的原理及应用进行分类综述和分析。 | 魏麟 朱方莉 周洋 Khairy Morsy MOHAMED 袁超 董星星 王小红 李锦铨 | 2018 | 食品科学2018，39，17： | 13 |
| 3 | 噬菌体在食品安全控制中的研究进展显示文摘近年来,噬菌体在食品科学领域中的应用受到国内外研究学者的广泛关注。噬菌体的自身特性表明,其可作为一种杀菌/抑菌的生物制剂来控制食源性病原菌对食品的污染,是保障食品安全的理想工具。此外,基因工程技术的发展进一步促进了噬菌体及其产物的安全、高效使用及噬菌体产品的出现。本文就噬菌体在食品安全控制中的研究进展以及应用前景等方面进行综述。 | 吕阳 尹平 Khairy Morsy MOHAMED 高磊 袁超 周洋 邱宁 邹璐瑶 李志 Abdelnabby HAZEM 王小红 李锦铨 | 2018 | 食品科学2018，39，15： | 8 |
| 4 | Genetic testing in congenital heart disease:A clinical approach显示文摘Congenital heart disease(CHD) is the most common type of birth defect. Traditionally, a polygenic model defined by the interaction of multiple genes and environmental factors was hypothesized to account for different forms of CHD. It is now understood that the contribution of genetics to CHD extends beyond a single unified paradigm. For example, monogenic models and chromosomal abnormalities have been associated with various syndromic and non-syndromic forms of CHD. In such instances, genetic investigation and testing may potentially play an important role in clinical care. A family tree with a detailed phenotypic description serves as the initial screening tool to identify potentially inherited defects and to guide further genetic investigation. The selection of a genetic test is contingent upon the particular diagnostic hypothesis generated by clinical examination. Genetic investigation in CHD may carry the potential to improve prognosis by yielding valuable information with regards to personalized medical care, confidence in the clinical diagnosis, and/or targeted patient followup. Moreover, genetic assessment may serve as a tool to predict recurrence risk, define the pattern of inheritance within a family, and evaluate the need for further family screening. In some circumstances, prenatal or preimplantation genetic screening could identify fetuses or embryos at high risk for CHD. Although genetics may appear to constitute a highly specialized sector of cardiology, basic knowledge regarding inheritance patterns, recurrence risks, and available screening and diagnostic tools, including their strengths and limitations, could assist the treating physician in providing sound counsel. | Marie A Chaix Gregor Andelfinger Paul Khairy | 2016 | World Journal of Cardiology2016，8，2： | 8 |
| 5 | Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer显示文摘Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome. | Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna Shafie Narazah Mohd Yusof Siti Razila Abdul Razak | 2018 | Cancer Biology & Medicine2018，15，1： | 6 |
| 6 | 两性霉素B角膜基质内注射成功治疗真菌性角膜炎1例(英文)显示文摘目的:报告1例使用5mg/L两性霉素成功治疗难治性真菌性角膜炎的病例。方法:病例报告。结果:女性患者1例,48岁,以右眼红1wk,伴视力下降和角膜混浊2d入院。否认有外伤或异物史。检查发现:右眼视力:6/12,针孔视力:6/18。注射结膜前使眼分泌物保持最少。角膜旁中央区有一全层基质脓肿-形态不规则且伴有卫星病灶及羽状边缘,不伴有上皮缺损,有前房积脓液平。左眼正常。诊断为真菌性角膜炎。尽管在此前患者经历了3wk的局部两性霉素B点眼(1次/2h),那他霉素眼液点眼(1次/4h),但并无病情恢复的迹象。相反12点出现了一个新的更大的基质脓肿病灶。我们应用5mg/L两性霉素B角膜基质注射联合穿透性角膜移植术治疗后溃疡面积明显减少,前房积脓完全消失,没有毒性反应发生。患者干预后2mo视力恢复了正常视力(6/6)。结论:使用两性霉素B5mg/L基质内注射,使用过程安全有效,是一种治疗难治性真菌性角膜炎的理想方法。 | Yanti Muslikhan Nor Sharina Yusof Khairy Shamel Sonny Teo Azhany Y aakob Mohtar Ibrahim | 2010 | 国际眼科杂志2010，10，11： | 4 |
| 7 | Identification of Differentially Expressed Genes Associated with Cotton Fiber Development in a Chromosomal Substitution Line(CS-B22sh)显示文摘One of the impediments in the genetic improvement of cotton fiber is the paucity of information about genes associated with fiber development.Availability of chromosome arm substitution line CS- | SOLIMAN Khairy M BOLTON James J SAHA Sukumar JENKINS Johnie N | 2008 | 棉花学报2008，20，S1： | 4 |
| 8 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 9 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 10 | Serum autoantibodies positivity prevalence in patients with chronic HCV and impact on pegylated interferon and ribavirin treatment response显示文摘 | Marwa Khairy Maissa El‐Raziky Wafaa El‐Akel Mohamed S. Abdelbary Hany Khatab Badawy El‐Kholy Gamal Esmat Mahassen Mabrouk | 2013 | Liver Int2013，，10： | 2 |
| 11 | Transeatheter closure versus medical therapy of patent foramen ovale and presumed paradoxical thromboemboli:a systematic review 显示文摘 | Khairy P O' Donnell CP Landzberg MJ | 2003 | Ann Intern Med2003，139，： | 1 |
| 12 | The new industrial revolution and industrial upgrading in China:achievements and challenges显示文摘One recent development in the area of manufacturing is the New Industrial Revolution(NIR).This paper examines the contours shaping the NIR,and analyses the challenges facing China in its pursuit to achieve technological parity with advanced nations.China’s economic rise is strongly associated with its ascending the technology ladder.The country is now the world’s workshop.As the labourintensive strategy based on cheap labour has run up against its limits,policy makers have devised plans that focus on industrial upgrading,promote indigenous innovations and establish national brands.This way China would avoid the middle-income trap and eventually become an innovative powerhouse. | Khairy Tourk Peter Marsh | 2016 | Economic and Political Studies2016，4，2： | 1 |
| 13 | Arrhythmias in adult con genital heart diseas显示文摘 | Khairy P Dore A Talajic M | 2006 | Expert Rev Cardiovasc Ther2006，4，1： | 1 |
| 14 | Value of programmed ventrieular stimulation after tetralogy of fallot repair:a multicenter study显示文摘 | Khairy P Landzberg M J Gatzoulis MA | | 0，，02： | 1 |
| 15 | Aberrant Expression of Critical Genes during Secondary Cell Wall Biogenesis in a Cotton Mutant, Ligon Lintless-1 ( L i -1)显示文摘 | James J. Bolton Khairy M. Soliman Thea A. Wilkins Johnie N. Jenkins Jeffrey Bennetzen | 2010 | Comparative and Functional Genomics2010，，： | 1 |
| 16 | Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead显示文摘 | THIBAULT B DUBUC M KHAIRY P | 2013 | Europace2013，15，： | 1 |
| 17 | Anxiety of the mothers with referred baby during Universal Newborn Hearing Screening显示文摘 | MOHD KHAIRI M D RAFIDAH K N AFFIZAL A | 2011 | Int J Pediatric Otorhinolaryngol2011，75，： | 1 |
| 18 | Increased mortality among patients taking digoxin--analysis from the AFFIRM study 显示文摘 | Wbitbeek MG Chamigo R J Khairy P | 2013 | Eur Heart J2013，34，20： | 1 |
| 19 | Exact SINR analysis of wireless OFDM in the presence of carrier frequency offset显示文摘 | HAMDI Khairi Ashour | 2010 | IEEE Transactions on Wireless Communications2010，9，3： | 1 |
| 20 | Ablation of atrioventricular nodal reentrant tachycardia in tricuspid atresia 显示文摘 | Khairy P Seslar SP Triedman JK | 2004 | J Cardiovasc Electrophysial2004，15，： | 1 |
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