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| 1 | Antibiotic Resistance of Probiotic Strains of Lactic Acid Bacteria Isolated from Marketed Foods and Drugs显示文摘Objective To identify the antimicrobial resistance of commercial lactic acid bacteria present in microbial foods and drug additives by analyzing their isolated strains used for fermentation and probiotics. Methods Antimicrobial susceptibility of 41 screened isolates was tested with disc diffusion and E-test methods after species-level identification. Resistant strains were selected and examined for the presence of resistance genes by PCR. Results Distribution of resistance was found in different species. All isolates were susceptible to chloramphenicol, tetracycline, ampicillin, amoxicillin/clavulanic acid, cephalothin, and imipenem. In addition, isolates resistant to vancomycin, rifampicin, streptomycin, bacitracin, and erythromycin were detected, although the incidence of resistance to these antibiotics was relatively low. In contrast, most strains were resistant to ciprofloxacin, amikacin, trimethoprim/sulphamethoxazole, and gentamycin. The genes msrC, vanX, and dfrA were detected in strains of Enterococcus faecium, Lactobacillus plantarum, Streptococcus thermophilus, and Lactococcus lactis. Conclusion Antibiotic resistance is present in different species of probiotic strains, which poses a threat to food safety. Evaluation of the safety of lactic acid bacteria for human consumption should be guided by established criteria, guidelines and regulations. | CHANG LIU, ZHUO-YANG ZHANG, KE DONG, JIAN-PING YUAN, AND XIAO-KUI GUO P1 P Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China | 2009 | Biomedical and Environmental Sciences2009，22，5： | 19 |
| 2 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 3 | Histogram analysis of MR imaging-derived cerebral blood volume maps:combined glioma grading and identification of low-grade oligodendroglial subtypes显示文摘AJNR, 2008 Jun 26.BACKGROUND AND PURPOSE: Inclusion of oligodendroglial tumors may confound the utility of MR based glioma grad-ing. Our aim was, first, to assess retrospectively whether a histogram-analysis method of MR perfusion images may both | Emblem KE Scheie D Due-Tonnessen P Nedregaard B Nome T Hald JK Beiske K Meling TR Bjornerud A | 2008 | 中国神经肿瘤杂志2008，6，2： | 5 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | Synthesis of substituted benzoxazoles by the iron(Ⅲ)-catalyzed aerobic oxidation process显示文摘The FeCl3-catalyzed aerobic oxidation process for the synthesis of benzoxazoles,benzothiazole and benzimidazole has been discovered.This method has proved to be effective to a wide range of substrates,and it has been applied for the synthesis of JTP-426467. | CAO Ke,TU YongQiang & ZHANG FuMin P State Key Laboratory of Applied Organic Chemistry and Department of Chemistry,Lanzhou University,Lanzhou 730000,China | 2010 | Science China Chemistry2010，53，1： | 3 |
| 6 | Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning显示文摘BACKGROUND Hepatic steatosis is a major cause of chronic liver disease.Two-dimensional(2D)ultrasound is the most widely used non-invasive tool for screening and monitoring,but associated diagnoses are highly subjective.AIM To develop a scalable deep learning(DL)algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.METHODS Using multi-view ultrasound data from 3310 patients,19513 studies,and 228075 images from a retrospective cohort of patients received elastography,we trained a DL algorithm to diagnose steatosis stages(healthy,mild,moderate,or severe)from clinical ultrasound diagnoses.Performance was validated on two multiscanner unblinded and blinded(initially to DL developer)histology-proven cohorts(147 and 112 patients)with histopathology fatty cell percentage diagnoses and a subset with FibroScan diagnoses.We also quantified reliability across scanners and viewpoints.Results were evaluated using Bland-Altman and receiver operating characteristic(ROC)analysis.RESULTS The DL algorithm demonstrated repeatable measurements with a moderate number of images(three for each viewpoint)and high agreement across three premium ultrasound scanners.High diagnostic performance was observed across all viewpoints:Areas under the curve of the ROC to classify mild,moderate,and severe steatosis grades were 0.85,0.91,and 0.93,respectively.The DL algorithm outperformed or performed at least comparably to FibroScan control attenuation parameter(CAP)with statistically significant improvements for all levels on the unblinded histology-proven cohort and for“=severe”steatosis on the blinded histology-proven cohort.CONCLUSION The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts.Diagnostic performance was high with comparable or better performance than the CAP. | Bowen Li Dar-In Tai Ke Yan Yi-Cheng Chen Cheng-Jen Chen Shiu-Feng Huang Tse-Hwa Hsu Wan-Ting Yu Jing Xiao Lu Le Adam P Harrison | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 7 | New geographical approaches to control of some parasitic zoonoses 显示文摘 | Mort KE Nuttall I Desjex P | 1995 | WHO Bull1995，73，： | 1 |
| 8 | Investigation into ^64Cu-labeled Bis (selenosemicarbazone)and Bis (thiosemicarbazone) complexes as hypoxia imaging agents 显示文摘 | McQuade P Martin KE Castle TC | 2005 | Nucl Med Biol2005，32，2： | 1 |
| 9 | The economic burden of major adult visual disorders in theUnited States显示文摘 | Rein DB Zhang P Wirth KE | 2006 | Arch Ophthalmol2006，124，12： | 1 |
| 10 | Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells显示文摘 | Schwab KE Hutchinson P Gargett CE | | 0，，04： | 1 |
| 11 | Facile fabrication of magnetic metal-organic framework nanoparticles for potential targeted drug delivery显示文摘 | KE F YUAN Y P QIU L G | | 0，，： | 1 |
| 12 | Microstructure and property evolution of Cr-DLC films with different Cr content deposited by a hybrid beam technique 显示文摘 | DAI W KE P L WANG A Y | 2006 | Thin Solid Films2006，514，： | 1 |
| 13 | The effects of interspinous implant on the kinematics of the instrumented and adjacent levels in the lumbar spine显示文摘 | Lindsey DP Swanson KE Fuchs P | 2003 | Spine2003，28，20： | 1 |
| 14 | Smoking and respiratory conditions in pregnancy: associations with adverse pregnancy outcomes显示文摘 | Kitsantas P Christopher KE | 2013 | South Med J2013，106，5： | 1 |
| 15 | Inhibitory effects of P-alkyl-benzoic acids on the activity of polyphenoloxidase from potato(Solanum tuberosum) 显示文摘 | LIN M KE L HAN P | 2010 | Food Chemistry2010，119，2： | 1 |
| 16 | Roentgenographic assessment of the biologic fixation of porous-surfaced femoral components 显示文摘 | Engh CA Massin P Suthers KE | 1990 | Clin Orthop Relat Res1990，，257： | 1 |
| 17 | The PIK3CA gene is mutated with high frequency in human breast cancers显示文摘 | Bachman KE Argani P Samuels Y | | 0，，08： | 1 |
| 18 | Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and Inhibiting NLRP3 inflammasome显示文摘 | Shao BZ Wei W Ke P | 2014 | CNS Neurosci Ther2014，20，12： | 1 |
| 19 | High-performance ceramic membrane with a separation layer of metal oxide nanofibers显示文摘 | Ke X B Zhu H Y Gao X P | 2007 | Adv Mater2007，19，6： | 1 |
| 20 | Controlling factors of spring-summer phytoplankton succession in Taihu Lake (Meiliang Bay, China) 显示文摘 | KE Z XIE P GUO L | 2008 | Hydrobiologia2008，607，： | 1 |
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