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| 1 | Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis显示文摘AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,2016.Inclusion criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end points.Primary efficacyoutcome was 'brain death or Cerebral Performance Category(CPC) score of 5'.Secondary outcomes were 'CPC score 1,and 2-4','overall thrombotic events' and 'acute coronary stent thrombosis'.RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical trials.No significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was observed.CONCLUSION Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy. | Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance显示文摘 | Kern PA Ranganathan S Li C | 2001 | Am J Physiol Endocrinol Metab2001，280，5： | 1 |
| 3 | Stochasticity in gene expression: from theories to phenotypes 显示文摘 | KERN M ELSTON C BLAKE W J | 2005 | Nat Tev Genet2005，6，： | 1 |
| 4 | Management of postoperative hem- orrhage following thyroid surgery 显示文摘 | Lorenz K Sekulla C Kern J | 2015 | Chirurg2015，86，1： | 1 |
| 5 | Stress and fold localization in thin e lastic membranes 显示文摘 | Pocivavsek L Dellsy R Kern A Johnson S Lin B Lee KY C Cerda E | 2008 | Science2008，320，： | 1 |
| 6 | Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway 显示文摘 | Kern C Comuel JF Billard C | 2004 | Blood2004，103，2： | 1 |
| 7 | Poly (ADP-ribose) polymeraseis involvedin the development of diabetic retinopathy via regulation of nuclear factor-kappaB 显示文摘 | Zheng L Szabo C Kern TS | 2004 | Diabetes2004，53，11： | 1 |
| 8 | Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance显示文摘 | Kern PA Ranganathan S Li C | 2001 | Am J Physiol Endocrinol Metab2001，280，5： | 1 |
| 9 | Poly (ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB显示文摘 | Zheng L Szab6 C Kern TS | 2004 | Diabetes2004，53，： | 1 |
| 10 | QTL for resistance to common rust and smut in maize显示文摘 | Kerns M R Dudley J W Rufener C K | 1999 | Maydica1999，44，： | 1 |
| 11 | Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols 显示文摘 | Kern H Hofer C Modlin M | 2002 | Artif Organs2002，26，3： | 1 |
| 12 | Nucleophosmin gene muta- tions are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype 显示文摘 | Schnittger S Schoch C Kern W | 2005 | Blood2005，106，： | 1 |
| 13 | Biofeedback - assisted relaxation therapy in neurocardiogenic syncope: a pilot study 显示文摘 | McGrady AV Kern - Buell C Bush E | 2003 | Appl Psychophysiol Biofeedback2003，28，3： | 1 |
| 14 | Variations in normal coronary vasodila tor reserve stratified by artery, gender, heart transplantation, and coronary artery disease显示文摘 | Bach RG Mechem C | 1996 | J Am Coll Cardiol1996，28，： | 1 |
| 15 | C erbB 2 expression in breast cancer detected by immunoblotting and immunohistochemistry 显示文摘 | Kerns B J M Pence J C Huper G etal | 1990 | Histochem Cytochem1990，38，： | 1 |
| 16 | Treadmill training withpartial baby weight support in nonambulatory patients with ce-rebral palsy显示文摘 | Schindl MR Forstner C Kern H | 2000 | Arch Phys Med Rehabil2000，81，3： | 1 |
| 17 | Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia:results of an age-justed prospective randomized comparison显示文摘 | Kern W Aul C Maschmyer G | 1998 | Leukemia1998，12，7： | 1 |
| 18 | Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway显示文摘 | Kern C Comuel JF Billard C | 2004 | Blood2004，103，： | 1 |
| 19 | Management of Acute Myeloid Leukemia in Elderly Patients显示文摘 | HIddeman W Kern W Schoch C | 1999 | J Clin Onc1999，17，： | 1 |
| 20 | Evaluation of the GlideScope for tracheal intubation in patients with cervical spine immobilisation by a semi-rigid collar显示文摘 | Bathory I Frasearolo P Kern C | 2009 | Anaesthesia2009，，64： | 1 |
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