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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Intraductal papillary mucinous neoplasm and the pancreatic incidentaloma显示文摘Asymptomatic pancreatic lesions(APL) are a commonly encountered problem in today's pancreatic surgical practices.Current literature regarding etiologies and incidence of APLs,particularly intraductal papillary mucinous neoplasm(IPMN),is presented.APLs constitute a wide spectrum of pathology(solid/cystic,benign/premalignant/malignant) but,overall,IPMN is now the most common diagnosis.The Sendai Guidelines and their function as a basis for risk stratification in branch duct IPMN are presented.The importance of traditionally analyzed cyst characteristics including size,presence of mucin or nodules and cyst fluid aspirate as indicators of malignancy is emphasized,noting also the potential correlation of main duct dilatation,thickened septae and elevated cyst fluid CEA with increased risk of malignancy.Current complication rates after resection of APLs are reviewed and found to be generally equivalent to those for symptomatic resections.A potential multidisciplinary treatment strategy is offered considering the costs of surgery versus repeated imaging or follow up endoscopy for these lesions.The decision for intervention is ultimately based on the Sendai Guidelines in the context of the individual patient. | Tara S Kent Charles M Vollmer Jr Mark P Callery | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 3 |
| 4 | Entrepreneurs innovation bringing job satisfaction,work-family balance,and life satisfaction:In China and around the world显示文摘Entrepreneurs work such,as innovation,may bring financial benefits and non-pecuniary benefits,such as well-being.Entrepreneurial innovation expectedly benefits an individuals job satisfaction,balance between work and family,and life satisfaction.This is tested for entrepreneurs in China and around the world,with a globally representative sample of 33,519 entrepreneurs,including 786 in China.Among entrepreneurs around the world,innovation benefits job satisfaction,the balance between work and family,and life satisfaction.In China,specifically,entrepreneurs innovation also benefits their satisfaction with the balance between work and family and with life. | Kent Wickstrøm Jensen Ye Liu Thomas Schøtt | 2017 | International Journal of Innovation Studies2017，1，4： | 2 |
| 5 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 6 | Molecular targets in the treatment of anxiety显示文摘 | Kent J M Mathew S J Gorman J M | 2002 | Biol Psychiatry2002，52，10： | 2 |
| 7 | Meat tenderness and muscle growth: is there any relationship? 显示文摘 | Koohmaraie M Kent M P Shackelford S D Veiseth E Wheeler T L | 2002 | Meat Science2002，62，： | 1 |
| 8 | Low-rate smokers显示文摘 | Owen N Kent P Wakefield M | 1995 | Preventive Medicine1995，24，1： | 1 |
| 9 | The lic- orice root derived isoflavin glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6 and 2C9 显示文摘 | Kent UM Aviram M Rosenbalt M | 2002 | Drug MetabDispos2002，30，6： | 1 |
| 10 | Behavior and design of reinforced concrete, steel, and steel-concrete coupling beams显示文摘 | KENT A HARRIES M EERI BINGNIAN GONG BAHRAM M SHAHROOZ | 2000 | Earthquake Spectra2000，16，4： | 1 |
| 11 | The common RRM approach to admission control for converged heterogeneous wireless networks 显示文摘 | Skehill R Barry M Kent W | 2007 | Wireless Communications IEEE2007，14，2： | 1 |
| 12 | The state of the art of thezebrafish model for toxicology and toxicologic patholo- gy research-Advantages and current limitations 显示文摘 | Spitsbergen J M Kent M L | 2003 | Toxicology Pathology2003，，： | 1 |
| 13 | Dietary copper requirement reevaluation for juvenile grouper,Epinephelus malabaricus,with an organic copper source显示文摘 | Lin Y H Shih C C Kent M | 2010 | Aquaculture2010，310，1： | 1 |
| 14 | Minimally invasive esophagectomy:state of the art显示文摘 | Kent MS Schuchert M Femando H Luketich JD | | 0，，3： | 1 |
| 15 | Frequently Asked Questions about Microbiologically Influenced Corrosion(MIC ) 显示文摘 | Kent R K Fitz M M Cline K G | 2004 | Forensic Eengineering and Laboratories2004，35，4： | 1 |
| 16 | Mycobacteriosis in zebrafish ( Danio rerio ) research facilities 显示文摘 | Kent M L Whipps C M Matthews J L | 2004 | Comparative Biochemistry and Physiology Part C2004，138，： | 1 |
| 17 | Dynamiccontrast- enhanced magnetic resonance imaging of canine braintumors 显示文摘 | ZHAO Q LEE S KENT M’SCHATZBERG S | 2010 | Vet Radiol Ultrasound2010，51，2： | 1 |
| 18 | Spatial and temporal variability in seed dynamics of machair sand dune plant communities, the Outer Hebrides, Scotland显示文摘 | Owen N W Kent M Dale M P | 2001 | Journal of Biogeography2001，28，5： | 1 |
| 19 | Minimally invasive resection of benign esophageal tumors 显示文摘 | Kent M D'Amato T Nordman C | 2007 | J Thorac Car Diovasc Surg2007，134，1： | 1 |
| 20 | Unilateral breast masses in men over 40 : a diagnostic dilemma显示文摘 | O' HANLON D M KENT P KERIN M J | 1995 | Am J Surg1995，170，： | 1 |
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