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| 1 | The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland显示文摘 | Kelly CB McDonnell AP Johnston TG | 2004 | J Psychopharmacol2004，18，4： | 1 |
| 2 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 3 | Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis显示文摘 | ZHANG Q YAMAZA T KELLY AP | 2009 | PLoS One2009，4，11： | 1 |
| 4 | Green Tea Extract and (-) -Epigallocatechin-3-Gallate Inhibit Mast Cell-Stimulated Type I Collagen Expression in Keloid Fibroblasts via Blocking PI -3K/Akt Signaling Pathways显示文摘 | Zhang QZ Kelly AP Wang L | 2006 | J Invest Dermatol2006，126，： | 1 |
| 5 | Medical and surgical therapies for keloids显示文摘 | Kelly AP | 2004 | Dermatol Ther2004，17，2： | 1 |
| 6 | Pseudofolliculitis barbae and acne keloidalis nuchae显示文摘 | Kelly AP | 2003 | Dermatol Clin2003，21，4： | 1 |
| 7 | Tumor-like stem cells derived from human keloid are governed by the inftlammatory niche driven by IL-17/IL-6 axis显示文摘 | Zhang Q Yemaza T Kelly AP | 2009 | PLoS One2009，4，11： | 1 |
| 8 | Halothiobacillus neapolitanus strain OSWA isolated from “The Old Sulphur Well” at Harrogate (Yorkshire, England)显示文摘 | Wood AP Woodall CA Kelly DP | 2005 | Syst Appl Microbiol2005，28，8： | 1 |
| 9 | The effects of tea polyphenolic compounds on hair loss among rodents显示文摘 | ESFANDIARI A KELLY AP | 2005 | Journal of the National Medical Association2005，97，8： | 1 |
| 10 | Medical and surgical therapies for keloids 显示文摘 | Kelly AP | 2004 | Dermatol Ther2004，17，2： | 1 |
| 11 | Upda*,e on the management o{ keloids 显示文摘 | Kelly AP | 2009 | Semin Cu- tan Med Surg2009，28，2： | 1 |
| 12 | Hypoxia-induced HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells:involvement of ERK1/2 and PF3K/Akt显示文摘 | Zhang Q Oh CK Messadi DV Duong HS Kelly AP Soo C | 2006 | Exp Cell Res2006，312，2： | 1 |
| 13 | Laparoscopic cholecystectomyin the transplant population显示文摘 | Courcoulas AP Kelly E Harbrecht BG | 1996 | Surg Endosc1996，10，5： | 1 |
| 14 | Green tea exact and ( - )-epigallo- catechin-3-gallate inhibit mast cell-stimulated type I collagen expressionin keloid fibroblasts via blocking PI-3K/AkT signaling pathways 显示文摘 | Zhang Q Kelly AP Wang L | 2006 | J Invest Derrnatol2006，126，12： | 1 |
| 15 | Update on the management ofkeloids显示文摘 | Kelly AP | 2009 | Semin Cutan Med Surg2009，28，2： | 1 |
| 16 | Medical and surgical therapies for keloids Dermatologic Therapy显示文摘 | Kelly AP | 2004 | Mermatol Ther2004，17，2： | 1 |
| 17 | Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis 显示文摘 | Zhang Q Yamaza T Kelly AP | 2009 | PLoS One2009，4，11： | 1 |
| 18 | Green Tea Extract and (-)-epigallocatechin-3-gallate inhibit mast cell-stimulated type Ⅰ collagen expression in keloid fibroblasts via blocking PI-3K/AkT signaling pathways显示文摘 | Zhang Q Kelly AP Wang L | 2006 | J Invest Dermatol2006，126，12： | 1 |
| 19 | Binding of cephalothin and cefotaxime to D- ala- D- ala peptidase reveals a functional basis of a natural mutation in a low - affinity penicillin - binding protein and in extended spectrum β - lactamases 显示文摘 | Kuzin AP Liu H Kelly JA | 1995 | Biochemistry1995，34，： | 1 |
| 20 | Medical and surgical therapies for keloids显示文摘 | Kelly AP | 2004 | Dermatol Ther2004，17，2： | 1 |
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