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| 1 | 悬吊技术在微血管减压术中的应用显示文摘BACKGROUND: The success of microvascular decompression (MVD) depends on the permanent and complete transposition of the offending vessels. This paper describes the stitched sling retraction techniques for treating trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN), focusing on the stitching point for slinging the offending artery in the appropriate direction. Between January 2007 and March 2009, 28 patients with TN, 5 patients with HFS, and 3 patients with GPN underwent MVD with a sling retraction technique. In cases of TN, MVD was performed using the infratentorial lateral supracerebellar approach, and the offending superior cerebellar artery was superomedially transposed with a sling stitched to the tentorium cerebelli. In cases of HFS, MVD was performed using the lateral suboccipital infrafloccular approach, and the offending vertebral artery was superolaterally transposed with a sling stitched to the petrous dura. In cases of GPN, MVD was performed using the transcondylar fossa approach, in which the posterior inferior cerebellar artery was inferolaterally mobilized with a sling secured to the jugular tubercle. No patient suffered recurrence in the follow-up period. For the sling retraction technique to be performed successfully, it is important for a stitch to be placed at a suitable site to sling the offending vessel in the intended direction. An appropriate surgical approach must be used to obtain a sufficient operative field for performing the stitching procedures safely. | Masuoka J Matsushima T Kawashima M Nakahara Y Funaki T Mineta T | 2011 | 中华神经外科疾病研究杂志2011，10，2： | 19 |
| 2 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine(SLC)by binding to the C-terminus of SLC显示文摘 | Hirose J Kawashima H Swope Willis M | 2002 | Biochim Biophys Acta2002，1571，3： | 1 |
| 5 | Stress-strain model for confined reinforced concrete in bridge piers 显示文摘 | Hoshikuma J and Kawashima K | 1997 | Journal of Structural Engineering ASCE1997，123，5： | 1 |
| 6 | 3489 hourly thermal load prediction for the next 24 hours by ARIMA, EWMA, LR, and an artificialneural network显示文摘 | Kawashima M Dorgan C E Mitchell J W | 1995 | ASHRAE Trans1995，101，1： | 1 |
| 7 | Imaging of the seminal vesicle and vas deferens 显示文摘 | Kim B Kawashima A Ryu J A | 2009 | Radiographics2009，29，4： | 1 |
| 8 | Unloading and reloading stress- strain model for confined concrete 显示文摘 | Sakai J Kawashima | 2006 | Structure En- gineering2006，132，1： | 1 |
| 9 | A review of the structure, and fundamental mechanisms and kinetics of the leaching of chalcopyrite 显示文摘 | Li Y Kawashima N Li J | 2013 | Adv Colloid Interface Sci2013，197，1： | 1 |
| 10 | Residual displacement response spectrum 显示文摘 | Kawashima K Macrae G A Hoshikuma J | 1998 | Journal of Structural Engineering (ASCE)1998，124，5： | 1 |
| 11 | Detection of cardiomyocyte death in a rat model of ischemia and reperfusion using 99Tcm-labeled Annexin Ⅴ显示文摘 | Taki J Higuchi T Kawashima A | | 0，，09： | 1 |
| 12 | Insulin down-regulates resistin mRNA through the synthesis of protein (s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes 显示文摘 | Kawashima J Tsuruzoe K Motoshima H | 2003 | Diabetologia2003，46，2： | 1 |
| 13 | Nonenzymatic browning reactions of dihydroxyacetone with amino acids or their esters显示文摘 | KAWASHIMA K ITOH H CHGATE J | 1980 | Agri Biol Chem1980，44，7： | 1 |
| 14 | Decomposition of organic compounds in water by direct contact of gas corona discharge: influ-ence of discharge conditions显示文摘 | Sano N Kawashima T Fujikawa J | 2002 | Industrial & Engineering Chemistry Research2002，41，24： | 1 |
| 15 | Evaluation of Thermal Expansion Coefficient of Twinned YBa2 Cu3 O7-8 Film for Prediction of Crack Fommtion on Various Substrates显示文摘 | Yamada Y Kawashima J Wen J G | 2000 | Japanese Journal of Applied Physics2000，39，3： | 1 |
| 16 | Stress-strain model for confined reinforced concrete in bridge piers 显示文摘 | Hoshikuma J Kawashima K | 1997 | Journal of Structural Engi- neering1997，123，5： | 1 |
| 17 | Critical Thickness and Effective Thermal Expansion Coefficient of YBCO Crystalline Fifin显示文摘 | Kawashima J Yanmda Y Hirabayashi I | 1998 | Physica C1998，306，12： | 1 |
| 18 | Using genomics to study legume seed development显示文摘 | Le B H Wagmaister J A Kawashima T | 2007 | Plant Physiology2007，144，2： | 1 |
| 19 | Theoretical and experimental dynamic behavior of a curved model bridge structure显示文摘 | Kawashima K Penzien J | 1979 | Earthquake Engineering and Structural Dynamics1979，7，2： | 1 |
| 20 | Hourly thermal load prediction for the next 24 hours by ARIMA,EWA,LR,and an artificial neural network显示文摘 | Kawashima M C E Dotgan J W Mitchell | 1995 | ASHRAE Transactions1995，101，： | 1 |
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