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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Small-molecule inhibitors specifically targeting type III secretion显示文摘 | Nordfelth R Kauppi A M Norberg H A | 2005 | Infect Immun2005，73，5： | 1 |
| 3 | The threedimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism 显示文摘 | Kauppi B Jakob C Farnegardh M | 2003 | J Biol Chem2003，278，22： | 1 |
| 4 | Accumulation of airborn elements from vehicles in transplanted lichens in urban sites 显示文摘 | GARTY J KAUPPI M KAUPPI A | 1996 | Journal of Environmental Quality1996，25，2： | 1 |
| 5 | Fall-related risk factors and heel quantitative ultrasound in the assessment of hip fracture risk : a 10-year follow-up of a nationally representative adult popu- lation sample 显示文摘 | Kauppi M Stenholm S Impivaara O | 2014 | Osteoporos Int2014，25，6： | 1 |
| 6 | The three-dimensional structures of antagonistic and agonistic forms of the glueocortieoid receptor ligand-binding domain显示文摘 | Kauppi B Jakob C Famegardh M | 2003 | J Biol Chem2003，278，22： | 1 |
| 7 | Attempt tomodel laboratory scale diffusion and retardation data显示文摘 | HOLTTAP SIITARI KAUPPI M HAKANEN M | 2001 | J ContamHydrol2001，47，： | 1 |
| 8 | Probing the effect of superplasticizer adsorption on the surface forces u?sing the colloidal probe AFM technique显示文摘 | Kauppi A Andersson K M Bergstrom L | 2005 | Cern Concr Res2005，35，1： | 1 |
| 9 | Enhancing Bioremediation of Diesel Fuel-Contaminated Soil in a Boreal Climate: Comparison of Biostimulation and Bioaugmentation 显示文摘 | Kauppi S Sinkkonen A Romantschuk M | 2011 | International Biodeterioration Biodegradation2011，65，2： | 1 |
| 10 | Thrombocytopenia anderythrocytosis in mice with a mutation in the gene encoding thehemoglobin beta minor chain 显示文摘 | Kauppi M Hilton AA Metcalf D | 2012 | Proceedings of the NationalAcademy of Sciences of the United States of America2012，109，： | 1 |
| 11 | Mitigation of carbon emission to the atmosphere by forest management 显示文摘 | Brown S Sathaye J Canell M Kauppi P E | 1996 | Commonwealth Forestry Review1996，75，： | 1 |
| 12 | Small molecule inhibitors specifically targeting type Ⅲ secretion显示文摘 | Nordfelth R Kauppi A M Norberg H A | 2005 | Infect Immun2005，73，5： | 1 |
| 13 | Probing the Effect of Superplasticizer Adsorption on the Surface Forces Usingthe Colloidal Probe AFM Technique显示文摘 | Kauppi A Andersson K M Bergstrom L | 2005 | Cement and Concrete Research2005，35，1： | 1 |
| 14 | The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking显示文摘 | Kauppi M Simonsen A Bremnes B | 2001 | J Cell Sci2001，115，5： | 1 |
| 15 | A comparison of postopera- tive C-reactive protein changes in primary and revision hip arthro- plasty in patients with rheumatoid arthritis 显示文摘 | Maenpaa H Laiho K Kauppi M | 2002 | J Arthroplasty2002，17，1： | 1 |
| 16 | The cervical spine in patients with ankylosing spondylitis显示文摘 | Laiho K Kauppi M | | 0，，： | 1 |
| 17 | Fall-related risk factors and heel quantitative ultrasound in the assessment of hip fracture risk: a 10-year follow-up of a nationally representative adult popula- tion sample 显示文摘 | Kauppi M Stenholm S Impivaara O | 2014 | Osteoporos Int2014，，： | 1 |
| 18 | Accumulation of airborne elements from vehicles in transplanted lichens in urban sites 显示文摘 | GARTY J KAUPPI M KAUPPI A | 1996 | Journal of Environmental Quality1996，125，： | 1 |
| 19 | Elevated incidence of hematologic malignancies in patients with Sjogren's syndrome compared with patients with rheumatoid arthritis(Finland)显示文摘 | Kauppi M Pukkala E Isomaki H | 1997 | Cancer Causes Control1997，8，2： | 1 |
| 20 | Natural attenuation is enhanced in previously contaminated and coniferous forest soils显示文摘 | Kauppi S Romantschuk M St(o)mmer R | 2012 | Environmental Science and Pollution Research2012，，191： | 1 |
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