|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 2 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 4 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 5 | Environment and Development: Sustainability Science 显示文摘 | Kates R W Clark W C Corell R | 2001 | Science2001，，292： | 1 |
| 6 | Global change in local places :how scale matters 显示文摘 | Wilbanks T J Kates R W | 1999 | Climate Change1999，43，： | 1 |
| 7 | Environment and Development: Sustainability Science显示文摘 | Kates R W Clark W C Corell R | 2001 | Science2001，292，： | 1 |
| 8 | Environ- ment and Development: Sustainability Science 显示文摘 | Kates R W Clark W C Corell R | 2001 | Science2001，292，5517： | 1 |
| 9 | Characterizing and Measuring Sustainable Development显示文摘 | Parries T M Kates R W | 2003 | Annual Review of Environment and Resources2003，28，13： | 1 |
| 10 | Sustainable Science显示文摘 | Kates R w Clark W Corell R | 2001 | Science2001，，5517： | 1 |
| 11 | Environment anddevelopment:sustainability science显示文摘 | Kates R W Clark W C Corell R | 2001 | Science2001，292，： | 1 |
| 12 | Characterizing a sustainability transition:goals,targets,trends,and driving force显示文摘 | PARRIS T M KATES R W | 2003 | Annual Review of Environment and Resources2003，28，13： | 1 |
| 13 | Environment and Development : Sus- Lainability Science显示文摘 | Kates R W ClarkWC Corell R | 2001 | Science2001，292，5517： | 1 |
| 14 | Sustainability science显示文摘 | KATES R W | | Science0，292，： | 1 |
| 15 | Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C 显示文摘 | VERVEER C ZONDERVAN P E TEN KATE F J W | 2012 | Liver Int2012，32，4： | 1 |
| 16 | Environment and development:Sustainability science显示文摘 | KATES R W CLARK W C CORELL R | 2001 | Science2001，292，5517： | 1 |
| 17 | Knowing better and losing even more: The use of knowledge in hazards management显示文摘 | White G F Kates R W Burton I | 2001 | Global Environmental Change Part B: Environmental Hazards2001，3，3： | 1 |
| 18 | Long - term trends and a sustainable transition显示文摘 | Kates R W Parris T M | 2003 | Proc Natl Acad USA2003，，100： | 1 |
| 19 | Environment and development:sustainability science显示文摘 | Kates R W Clark W C Corell R | 2001 | Science2001，292，： | 1 |
| 20 | Reconstruction of New Orleans after Hurricane Katrina: A research perspective 显示文摘 | Kates R W Colten C E Laska S | 2006 | Pro- ceedings of the National Academy of Sciences2006，103，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员