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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 3 | Flow perfusion culture of human mesenchymal stem cells on silicate-sub- stituted tricalcium phosphate scaffolds显示文摘 | Bjerre L Bianger C E Kassem M | 2008 | Biomaterials2008，29，17： | 1 |
| 4 | Evaluation of flexural behavior and serviceability performance of concrete beams reinforced with FRP Bars 显示文摘 | Kassem C Farghaly A S Benmokrane B | 2011 | Journal of composites for construction2011，15，5： | 1 |
| 5 | Eval- uation of Flexural Behavior and Serviceability Per- formance of Concrete Beams Reinforced with FRP Bars显示文摘 | KASSEM C AHMED SABRY F BRAHIM B | 2011 | Journal of Composites for Construction2011，15，68： | 1 |
| 6 | Pegviso- mant-induced serum insulin-like growth factor- I normali- zation in patients with acromegaly returns elevated markers of bone turnover to normal 显示文摘 | Parkinson C Kassem M Heickendorff L | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 7 | Postmortem analysis of calendar- aged graphite/LiFePO4 cells 显示文摘 | KASSEM M DELACOURT C | 2013 | Journal of Power Sources2013，235，： | 1 |
| 8 | Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice 显示文摘 | Bentzon J F Sondergaard C S Kassem M | 2007 | Circulation2007，116，18： | 1 |
| 9 | Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation 显示文摘 | Foster L J Zeemann PA Li C Mann M Jensen ON Kassem M | 2005 | Stem Cells2005，23，： | 1 |
| 10 | Pegvisomant-inducedserum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal显示文摘 | Parkinson C Kassem M Heickendorff L | 2003 | Journal of Clinical Endocrinology & Metabolism2003，88，12： | 1 |
| 11 | Neuronal damage and functional deficits are ameliorated by inhibition of aqua porin and HIF-1a after traumatic brain injury(TBI)显示文摘 | Shenaq M Kassem H Peng C | 2012 | J Neurol Sci2012，323，12： | 1 |
| 12 | Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer显示文摘 | Ellinger J El Kassem N Heukamp L C | 2008 | J Urol2008，179，1： | 1 |
| 13 | Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIFla after traumatic brain injury (TBl)显示文摘 | Shenaq M Kassem H Peng C | 2012 | J Neurol Sci2012，323，： | 1 |
| 14 | Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting:single institution experience and meta-analysis显示文摘 | Parolari A Pesce L L Trezzi M Loardi C Kassem S Brambillasca C | 2009 | Eur Heart J2009，30，： | 1 |
| 15 | Deployment issues for the IP multicast service and architecture显示文摘 | Diot C Levine B N Lyles B Kassem H Balensiefe D | 2000 | IEEE Network2000，1，14： | 1 |
| 16 | Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells显示文摘 | Stenderup K Justesen J Clausen C Kassem M | | 0，，06： | 1 |
| 17 | Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1αafter traumatic brain injury(TBI)显示文摘 | Shenag M Kassem H Peng C | 2012 | J Neurol Sci2012，323，12： | 1 |
| 18 | The Influence of Lamel- lar Orientation on Corneal Material Behavior: Biomeehanical and Struetural Changes in an Avian Corneal Disorder显示文摘 | Boote C Elsheikh A Kassem W | 2011 | Inves- tigative Ophthalmology & Visual Science2011，52，3： | 1 |
| 19 | Pegvisomantinduced serum insulin-like growth factor-Ⅰ normalization in patients with acremegaly returns elevated markers of bone turnover to normal 显示文摘 | Parkinson C Kassem M Heickendorff L | 2003 | J Clin Endocrinol Metab2003，88，12： | 1 |
| 20 | Deployment issues for the IP multicast service and architecture显示文摘 | DIOT C LEVINE B N LYLES B KASSEM H BALENSIEFEN D | 2000 | IEEE Network2000，14，1： | 1 |
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