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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | Electrocardiographic markers of cardiac resynchronization therapy response:delayed time to intrinsicoid deflection onset in lateral leads显示文摘Cardiac resynchronization therapy(CRT)has emerged as an important intervention for patients with heart failure(HF)with reduced ejection fraction and delayed ventricular activation.In these patients,CRT has demonstrated to improve quality of life,promote reverse left ventricular(LV)remodeling,reduce HF hospitalizations,and extend survival.However,despite advancements in our understanding of CRT,a significant number of patients do not respond to this therapy.Several invasive and non-invasive parameters have been assessed to predict response to CRT,but the electrocardiogram(ECG)has remained as the prevailing screening method albeit with limitations.Ideally,an accurate,simple,and reproducible ECG marker or set of markers would dramatically overcome the current limitations.We describe the clinical utility of an old ECG parameter that can estimate ventricular activation delay:the onset to intrinsicoid deflection(ID).Based on the concept of direct measurement of ventricular activation time(intrinsic deflection onset),time to ID onset measures on the surface ECG the time that the electrical activation time takes to reach the area subtended by the corresponding surface ECG lead.Based on this principle,the time to ID on the lateral leads can estimate the delay activation to the lateral LV wall and can be used as a predictor for CRT response,particularly in patients with non-specific intraventricular conduction delay or in patients with left bundle branch block and QRS<150 ms.The aim of this review is to present the current evidence and potential use of this ECG parameter to estimate LV activation and predict CRT response. | Rubén KA Tapia-Orihuela S Michael Gharacholou Samuel J Asirvatham Freddy Del-Carpio Munoz | 2022 | Journal of Geriatric Cardiology2022，19，1： | 3 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 5 | 年龄≥65岁男性收缩压与血管疾病的相关性显示文摘老年人血压与血管疾病的关系尚不确定。1996-1999年,在澳大利亚西部帕斯普通人群中建立65~94岁男性7564人的前瞻性队列,评估收缩压与主要血管事件的相关性。测定基线和2001-2004年再调查时的收缩压。记录受试者的致命性及非致命性血管事件。 | Lacey B Golledge J Yeap BB Lewington S McCaul KA Norman PE Flicker L Almeida OP Hankey GJ 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 6 | Mother-infant interaction and breastfeeding outcome 6 weeks after birth显示文摘 | Brandt KA Andrews CM Kvale J | 1998 | JOGNN1998，27，： | 1 |
| 7 | Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondroeytes 显示文摘 | Huang J Ballou LR Hasty KA | 2007 | Gene2007，404，： | 1 |
| 8 | A 3-D reconstruction of smooth muscle alpha-actinin by cryoEM reveals two different conformations at the actin binding region显示文摘 | Liu J Taylor DW Taylor KA | 2004 | J Mol Biol2004，338，1： | 1 |
| 9 | Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription 显示文摘 | Mowen KA Tang J Zhu W | 2001 | Cell2001，104，5： | 1 |
| 10 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 11 | Multisection CT:Scanning Techniques and Clinical Applications显示文摘 | Rydberg J Buckwalter KA Caldemeyer KS | 2000 | Radiographics2000，20，6： | 1 |
| 12 | Oxidative stress and neutrophil activation-the two keystones of ischemia/ reperfusion injury显示文摘 | Kaminski KA Bondu TA Korechi J | 2002 | IntJcardiol2002，86，1： | 1 |
| 13 | Fingerprinting the circulating repertoire of antibodies from cancer patients显示文摘 | Kim J Do KA | 2003 | Nat Biotechnol2003，21，1： | 1 |
| 14 | Lung infections:role of apoptosis in host defense and pathogenesis of disease显示文摘 | Behnia M Robertson KA Martin W J 2nd | 2000 | Chest2000，117，6： | 1 |
| 15 | Soft-tissue balancing during total knee arthroplasty in the varus knee显示文摘 | Mihalko WM Saleh K J Krackow KA | 2009 | J Am Acad Orthop Surg2009，17，12： | 1 |
| 16 | Severe vincristine toxicity in combination with itraconazole显示文摘 | Gillies J Hung KA Fitzsimons E | 1998 | Clin Lab Haematol1998，20，2： | 1 |
| 17 | Evaluation of the Faces Pain Scale for use with the elderly显示文摘 | Herr KA Mobily PR Kohout F J | 1998 | Clin J Pain1998，14，： | 1 |
| 18 | Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation:Interim results of a prospective multicenter surveillance program显示文摘 | Morgan J Wannemuehler KA Marr KA | 2005 | Med Mycol2005，43，1： | 1 |
| 19 | Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice显示文摘 | McClellan KA Robertson FG Kindblom J Wennbo H Tornell J Bouchard B | 2001 | Invest Ophthalmol Vis Sci2001，42，1： | 1 |
| 20 | Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery显示文摘 | Leber KA Bergloff J Pendl G | 1998 | J Neurosurg1998，88，： | 1 |
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