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	题名	作者	年代	出处	被引量
1	Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology显示文摘AIM:To assess human epidermal growth factor receptor-2 (HER2)-status in gastric cancer and matched lymph node metastases by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH).METHODS:120 cases of primary gastric carcinomas and 45 matched lymph node metastases from patients with full clinicopathological features were mounted onto multiple-punch and single-punch tissue microarrays,respectively,and examined for HER2 overexpression and gene amplification by IHC and CISH.RESULTS:Twenty-four tumors (20%) expressed HER2 immunohistochemically.An IHC score of ≥ 2+ was observed in 20 tumors (16.6%).HER2 amplification was detected by CISH in 19 tumors (15.8%) and in their matched lymph node metastases.A high concordancerate was found between HER2 positivity (as detected by IHC) and HER2 gene amplification (as detected by CISH),since 19 of the 20 IHC positive cases were amplified (95%).All amplified cases had 2+ or 3+ IHC results.Amplification was associated with intestinal phenotype (P < 0.05).No association with grading,staging or survival was found.CONCLUSION:In gastric cancer,HER2 amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases.	Dimitrios Tsapralis Ioannis Panayiotides George Peros Theodore Liakakos Eva Karamitopoulou	2012	World Journal of Gastroenterology2012，18，2：	8
2	Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high‐level CpG Island methylator phenotype and mismatch repair‐deficiency显示文摘	Heather Dawson José A. Galván Melina Helbling Dominique‐Elisabeth Muller Eva Karamitopoulou Viktor H. Koelzer Mary Economou Caroline Hammer Alessandro Lugli Inti Zlobec	2014	Int. J. Cancer2014，，10：	2
3	Tumor budding:a promising parameter in colorectal cancer显示文摘	LUGLI A KARAMITOPOULOU E ZLOBEC L		0，，11：	1
4	Tumour budding is a strong and independent prognostic factor in pancreatic cancer显示文摘	E. Karamitopoulou I. Zlobec D. Born A. Kondi-Pafiti P. Lykoudis A. Mellou K. Gennatas B. Gloor A. Lugli	2012	European Journal of Cancer2012，，：	1
5	Loss Ecadherin independently predicts the lymph node status in colorectal cancer显示文摘	Karamitopoulou E Zlobec I Patsouris E	2011	Pathology2011，43，2：	1
6	Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer显示文摘	Koelzer VH Karamitopoulou E Dawson H	2013	Br J Cancer2013，108，10：	1
7	Loss of E-cadherin independently predicts the lymph node status in colorectal cancer显示文摘	Karamitopoulou E Zlobec I Patsouris E	2011	Pathology2011，43，2：	1
8	Loss of E-cadherin in- dependently predicts the lymph node status in colorectal cancer 显示文摘	Karamitopoulou E Zlobec I Patsouris E	2011	Pathology2011，43，2：	1
9	Ge- ographic analysis of RKIP expression and its clinical rel- evance in coloreetal cancer 显示文摘	Koelzer V H Karamitopoulou E Dawson H	2013	Br J Cancer2013，108，10：	1
10	p53 protein expression in central nervous system tumors显示文摘	Karamitopoulou E Parentes E Diamantis I	1993	Acta Neuropathol1993，85，6：	1
11	Loss of the CBX7 protein expression correlates with a more aggres- sive phenotype in pancreatic cancer显示文摘	Karamitopoulou E Pallante P Zlobec I	2010	Eur J Cancer2010，46，8：	1
12	Loss of E- cadherin independently predicts the lymph node status in colorectal cancer显示文摘	Karamitopoulou E Zlobec I Patsouris ES	2011	Pathology2011，43，2：	1
13	Loss of Ecadherin independently predicts the lymph node status in colorectal cancer显示文摘	Karamitopoulou E Zlobec I Patsouris E	2011	Pathology2011，43，2：	1
14	Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer 显示文摘	Karamitopoulou E Pallante P Zlobec I	2010	Eur J Cancer2010，46，8：	1
15	Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia an d endometrial carcinoma显示文摘	Berclaz G Karamitopoulou E Mazzucchelli L	2003	Ann Oncol2003，14，2：	1
16	Loss of E-cadherin independently predicts the lymph node status in colorectal cancer显示文摘	Karamitopoulou E Zlobec I Patsouris E	2011	Pathology2011，43，2：	1
17	Gastrointes- tinal stromal tumors (GISTs): an updated experience 显示文摘	Maehairas A Karamitopoulou E Tsapralis D	2010	Dig Dis Sci2010，55，12：	1
18	The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin- 3 reactivity显示文摘	Dawson H Andre S Karamitopoulou E	2013	Anticancer Res2013，33，8：	1
19	Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer显示文摘	Karamitopoulou E Zlobec I Panayiotides I	2011	Hum Pathol2011，42，12：	1
20	Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer显示文摘	HORCIC M KOELZER V H KARAMITOPOULOU E	2013	Hum Pathol2013，44，5：	1

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