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| 1 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 2 | Renal function before and after pyeloplasty:does it improve?显示文摘 | Mcaleer I M Kaplan G W | 1999 | J Urol1999，162，32： | 1 |
| 3 | Genetic transmission of fibrcdysplasia ossificans progressiva显示文摘 | Kaplan FS Mccluskey W Hahn G | 1993 | The Journal of Bone and Joint Surger1993，75，8： | 1 |
| 4 | Human bocavirus infection among children,Jordan 显示文摘 | Kaplan NM Dove W Abu-Zeid AF Shamoon HE Abd-Eldayem SA Hart CA | 2006 | Emerg Infect Dis2006，12，9： | 1 |
| 5 | Laser induced Cu/alumina bonding:Microstructure and bond mechanism显示文摘 | Shepeleva L Medres B Kaplan W D | 2000 | Surface & Coatings Technology2000，125，： | 1 |
| 6 | Identifying and treating eating disorders 显示文摘 | KAPLAN D W BLYTHE M DIAZ A | 2003 | Pediatr2003，111，1： | 1 |
| 7 | The age curves of the sulfur and oxygen isotopes in marine sulfur and their mutual interpretation 显示文摘 | Claypool G E Hoslter W T Kaplan I R | 1980 | Chemical Geology1980，28，： | 1 |
| 8 | Zero-valent iron for thein situ remediation of selected metals in groundwater显示文摘 | Cantrell K J Kaplan D I Wietsma T W | 1995 | Journalof Hazardous Materials1995，42，2： | 1 |
| 9 | Effect of SiC submicrometer particle size and content on frac ture toughness of alumina SiC nanocomposites显示文摘 | Kaplan W P Brandon D G | 1995 | J Am Ceram Soc1995，78，1： | 1 |
| 10 | Diagnosis and management of patients with thyroid nodules显示文摘 | LAWRENCE W J R KAPLAN B J | 2002 | J Surg Oncol2002，80，3： | 1 |
| 11 | Lithium isotope determination bu neutron activation 显示文摘 | Kaplan L Wilzbach W E | 1954 | Analytical Chemistry1954，，26： | 1 |
| 12 | Diagnosis and management of patients with thyroid nodules显示文摘 | Lawrence W Jr Kaplan BJ | 2002 | J Surg Oneo12002，80，3： | 1 |
| 13 | Nonconvulsive status epilepticus in the emergency room显示文摘 | Kaplan P W | 1996 | Epilepsia1996，37，： | 1 |
| 14 | The EEG of Status Epilepticus显示文摘 | Kaplan Peter W | 2006 | J Clin Neurophysiol2006，23，3： | 1 |
| 15 | The age curves of sulfur and oxygen isotopes in marine sulfate and their mutual interpretation 显示文摘 | Claypool G E Holser W T Kaplan I R | 1980 | Chemical Geology1980，28，： | 1 |
| 16 | Subcutaneous phae- ohyphomycosis caused by Exophiala spinifera显示文摘 | Padhye AA Kaplan W Neuman MA | 1984 | Sabouraudia1984，22，6： | 1 |
| 17 | On the advantage ofhaplotype analysis in the presence of multiple diseasesusceptibility alleles显示文摘 | Morris R W Kaplan N L | 2002 | Genetic Epidemiology2002，23，3： | 1 |
| 18 | Fault-induced polytypism in (Cr, Fe)2B 显示文摘 | Goldfarh I Kaplan W D Ariely S | 1995 | Philosophical Magazine A1995，72，4： | 1 |
| 19 | A prospective trial of colchicine for primary biliary cirrhosis 显示文摘 | Kaplan M M Ailing D W Zimmerman H J | 1986 | Engl J Med1986，315，23： | 1 |
| 20 | Isotope Geochemistry ofSedimentary Sulfates显示文摘 | Holser W T Kaplan I R | 1966 | Chem Geol1966，1，： | 1 |
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