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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | BACE1 suppression by RNA interference in primary cortical meurons显示文摘 | Kao S C Krichevsky A M Kosik K S | 2004 | Biol Chem2004，279，3： | 1 |
| 3 | Influence of thermal effect on output power optimization in fiber-coupled laser- diode end-pumped lasers 显示文摘 | Chert Y F Huang T M Kao C F | 1997 | IEEE J Quantum Electron1997，3，1： | 1 |
| 4 | Evaluating spatiotemporal differences and sustainability of Xiamen urban metabolism using emergy synthesis显示文摘 | YANG Dewei KAO W T M ZHANG Guoqin | 2014 | Ecological Modelling2014，272，： | 1 |
| 5 | One-pot synthesis of ordered and stable cubic mesoporous silica SBA-1 functionalized with amino functional groups显示文摘 | KAO H M LIAO C H PALANI A | 2008 | Microporous Mesoporous Mater2008，113，13： | 1 |
| 6 | Lipid accumulation and CO2utilization of Nannochloropsis oculata in response to CO2 aeration显示文摘 | Chiu S Y Kao C Y Tsai M T | 2009 | Bioresource Technology2009，100，： | 1 |
| 7 | Callus formation and plant regeneration from mesophyll protoplasts of rape plant 显示文摘 | Kart ha K K Michayluk M R Kao K N | 1974 | Plant Sci Lett1974，，3： | 1 |
| 8 | The dynamics of an infectious disease in a population with birth pulse显示文摘 | ROBERTS M G KAO R R | 1998 | Math Biosci1998，149，1： | 1 |
| 9 | Chmaeteristics of particles sampled in southern Taiwan during the Asian dust storm periods in 2000 and 2001 显示文摘 | CHEN S J HSIEH LT KAO M J | 2004 | Atmos Environ2004，38，： | 1 |
| 10 | Effect of Calcium Sulfate Concentration in Soymilk on the Microstructure of Firm Toil/and the Protein Consti- tutions in Tofu Whey显示文摘 | KAO F SU N LEE M | 2003 | Journal of Agricultural and Food Chemistry2003，51，： | 1 |
| 11 | Regulating colored textile wastewater by 3/31 wavelength admi methods in Taiwan 显示文摘 | Kao C Chou M Fang W | 2001 | Chemosphere2001，44，5： | 1 |
| 12 | CFD analysis of PWR core top and reactor vessel upper plenum intemals subdomain models显示文摘 | Kao M T Wu C Y Chieng C C | 2011 | Nuclear Engineering and Design2011，241，41： | 1 |
| 13 | Lipid accumulation and CO2 utilization ofNannochloropsisoculata in response to CO2 aeration显示文摘 | Chiu S Y Kao C Y Tsai M T | 2009 | Bioresource Technology2009，100，2： | 1 |
| 14 | The negative effect of combination of rh BMP-2 and Bio-Oss on bone formation for maxillary sinus augmentation显示文摘 | Kao D Kubota A Nevins M | 2012 | Int J Periodontics Restorative Dent2012，32，1： | 1 |
| 15 | Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow 显示文摘 | Katayama Y Battista M Kao W M | 2006 | Cell2006，124，2： | 1 |
| 16 | Embryoid formation in alfalfa cell suspension cultures from different plants显示文摘 | Kao K N Michayluk M R | 1981 | Tissue Culture Association1981，7，： | 1 |
| 17 | Nighttime Vehicle Distance Measuring Systems显示文摘 | WANG W Y LU M C KAO H L CHU C Y | 2007 | IEEE Transactions on Circuits and System2007，54，1： | 1 |
| 18 | Hepatitis B virus genotypes correlate with clinical outcomes in patients with chronic hepatitis B 显示文摘 | KAO J H CHEN P J LAI M Y | 2000 | Gastroenterology2000，18，3： | 1 |
| 19 | Local contrast enhance- ment and adaptive feature extraction for illumination invariant face recognition显示文摘 | Kao W C Hsu M C Yang Y Y | 2010 | Pattern Recognition2010，43，： | 1 |
| 20 | Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer显示文摘 | KAO J GENDEN E M CHEN C T | 2011 | Cancer2011，117，14： | 1 |
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