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| 1 | Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers:comparison between recurrent acute and chronic pancreatitis显示文摘BACKGROUND: Diagnostic parameters that can predict the presence of chronic pancreatitis(CP) in patients with recurrent pain due to pancreatitis would help to direct appropriate therapy. This study aimed to compare the serum levels of monocyte chemoattractant protein-1(MCP-1), transforming growth factor-β1(TGF-β1), nerve growth factor(NGF), resistin and hyaluronic acid(HA) in patients with recurrent acute pancreatitis(RAP) and CP to assess their ability to differentiate the two conditions.METHODS: Levels of serum markers assessed by enzymelinked immunosorbent assay(ELISA) were prospectively compared in consecutive patients with RAP, CP and in controls and stepwise discriminant analysis was performed to identify the markers differentiating RAP from CP.RESULTS: One hundred and thirteen consecutive patients(RAP=32, CP=81) and 78 healthy controls were prospectively enrolled. The mean(SD) age of the patients was 32.0(14.0)years; 89(78.8%) were male. All markers were significantly higher in CP patients than in the controls(P<0.001); MCP-1NGF and HA were significantly higher in RAP patients than in the controls(P<0.001). Stepwise discriminant analysis showed significant difference(P=0.002) between RAP and CP for resistin with an accuracy of 61.9%, discriminant scores of ≤-0.479 and ≥0.189 indicating RAP and CP, respectively. The other markers had no differential value between RAP and CP.CONCLUSION: Serum resistin is a promising marker to differentiate between RAP and CP and needs validation in future studies, especially in those with early CP. | M Ganesh Kamath C Ganesh Pai Asha Kamath Annamma Kurien | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 7 |
| 2 | Transjugular intrahepatic portosystemic stent shunt for medically refractory hepatic hydrothorax:A systematic review and cumulative meta-analysis显示文摘AIM:To assess the effectiveness of transjugular intrahepatic portosystemic stent shunt(TIPSS) in refractory hepatic hydrothorax(RHH) in a systematic review and cumulative meta-analysis.METHODS:A comprehensive literature search was conducted on MEDLINE,EMBASE,and Pub Med covering the period from January 1970 to August 2014.Two authors independently selected and abstracted data from eligible studies.Data were summarized using a random-effects model.Heterogeneity was assessed using the I2 test.RESULTS:Six studies involving a total of 198 patients were included in the analysis.The mean(SD) age of patients was 56(1.8) years.Most patients(56.9%) had Child-Turcott-Pugh class C disease.The mean duration of follow-up was 10 mo(range,5.7-16 mo).Response to TIPSS was complete in 55.8%(95%CI:44.7%-66.9%),partial in 17.6%(95%CI:10.9%-24.2%),and absent in 21.2%(95%CI:14.2%-28.3%).The mean change in hepatic venous pressure gradient post-TIPSS was 12.7 mm Hg.The incidence of TIPSS-related encephalopathy was 11.7%(95%CI:6.3%-17.2%),and the 45-d mortality was 17.7%(95%CI:11.34%-24.13%).CONCLUSION:TIPSS is associated with a clinically relevant response in RHH.TIPSS should be considered early in these patients,given its poor prognosis. | Ivo C Ditah Badr F Al Bawardy Behnam Saberi Chobufo Ditah Patrick S Kamath | 2015 | World Journal of Hepatology2015，7，13： | 5 |
| 3 | Acute-on chronic liver failure显示文摘 | Rajiv Jalan Pere Gines Jody C Olson Rajeshwar P Mookerjee Richard Moreau Guadalupe Garcia-Tsao Vicente Arroyo Patrick S Kamath | 2012 | Journal of Hepatology2012，，6： | 4 |
| 4 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 5 | Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis显示文摘 | Palendira U Kamath A T Feng C G | | Infect Immun0，20，： | 2 |
| 6 | Graphite particles reinforced ZA-27 alloy composite materials for journal bearing applications 显示文摘 | Sharma S C Girish B M Kamath R | 1998 | Wear1998，219，2： | 1 |
| 7 | A new approach to detect congestive heart failure using Teager energy nonlinear scatter plot of R-R interval series显示文摘 | Kamath C | 2012 | Med Eng Phys2012，34，7： | 1 |
| 8 | A clinical and mycological study of onychomycosis in HIV infection 显示文摘 | Surjushe A Kamath R Oberai C | 2007 | Indian J Dermatol Venereol Leprol2007，73，6： | 1 |
| 9 | Robust background subtraction with foreground validation for urban traffic video 显示文摘 | CHEUNG S S KAMATH C | 2005 | Eurasip Journal on Applied Signal Processing2005，2005，14： | 1 |
| 10 | Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis显示文摘 | Kamath A T Feng C G Macdonld M | 1999 | Infect Immun1999，67，： | 1 |
| 11 | Effect of SiC particle reinforcement on the unlubricated sliding wear behaviour of ZA-27 alloy composites 显示文摘 | Sharma S C Girish B M Kamath R | 1997 | Wear1997，213，12： | 1 |
| 12 | Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope显示文摘 | Feng CG Demangel C Kamath AT | 2001 | Int Immunol2001，13，4： | 1 |
| 13 | Gellan film as an implant for insulin delivery 显示文摘 | Li J Kamath K Dwivedi C | 2001 | JBiomaterAppl2001，15，4： | 1 |
| 14 | Robust background subtraction with foreground validation for urban video显示文摘 | CHEUNG S C S KAMATH C | 2005 | Eurasip Journal on Ap- plied Signal Processing2005，，14： | 1 |
| 15 | Erythrocyte indicators of oxidativestress in gestational diabetes显示文摘 | Kamath U Rao G Raghothama C | 1998 | Acta Paediatr1998，87，4： | 1 |
| 16 | Study of asp Halt/asphaltene precipitation during addition of solvents to West Sak crude显示文摘 | Jiang J C Patil S L Kamath V A | 1990 | Preprints Div Petrol Chem ACS1990，17，3： | 1 |
| 17 | The subcorticaI anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar显示文摘 | KAMATH H O HIMMELBACH M RORDEN C | 2002 | Brain2002，125，2： | 1 |
| 18 | Mechanical properties and fractography of zircon-particle-reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R KAMATH R SATISH B M | 1999 | Composite Science and Technology1999，59，： | 1 |
| 19 | Elongated styloid process ( Eagle 's syndrome) : a clinical study 显示文摘 | Prasad K C Kamath M P Reddy K J | 2002 | J Oral Maxillofac Surg2002，60，2： | 1 |
| 20 | Robust techniques for background sub- traction in urban traffic video显示文摘 | CHEUNG S-C S KAMATH C | 2004 | Visual Communications and Im- age Processing2004，5308，1： | 1 |
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