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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Magnetic resonance cholangiopancr - eatography documents bile leak site after cholecystectomy in patients with aberrant right hepatic duct where ERCP fails 显示文摘 | Kalayci C Aisen A Canal D | 2000 | Gastrointest Endosc2000，52，2： | 1 |
| 3 | Equilibrium,kinetic and thermodynamic studies on the adsorption of phenol onto chitin显示文摘 | Arzu Y Dursun C Seda Kalayci | 2005 | Journal of Hazardous Materials2005，123，： | 1 |
| 4 | Microbiology of bile in patients with cholangitis or cholestasis with and without plastic biliary endoprosthesis显示文摘 | Rerknimitr R Fogel EL Kalayci C | 2002 | Gastrointest Endosc2002，56，6： | 1 |
| 5 | Esomeprazole in Acute and Maintenance Treatment of Reflux Oesophagitis:a Multicentre Prospective Study显示文摘 | Atug O Giral A Kalayci C | 2008 | Adv Ther2008，25，6： | 1 |
| 6 | Equilibrium, kinetic and thermodynamic studies on the adsorption of phenol onto chitin 显示文摘 | Arzu Y Dursun C Seda Kalayci | 2005 | Journal of Hazardous Materials2005，123，： | 1 |
| 7 | Pharmacokinetics and toxicity of intraarterial adriamycin for hepatocellular carcinoma:effect of coadministration of lipiodol显示文摘 | Johnson PJ Kalayci C Dobbs N | 1991 | Hepatology1991，13，： | 1 |
| 8 | Equilibrium, kinetics and thermodynamic studies on the adsorption of phenol onto chitin 显示文摘 | DURSUN A Y KALAYCI C S | 2005 | Journal of Hazardous Materials B2005，123，123： | 1 |
| 9 | A tabu search algorithm for balan- cing a sequence-dependent disassembly line显示文摘 | Kalayci C B Gupta S M | 2014 | Production Planning & Control2014，25，2： | 1 |
| 10 | A particle swarm optimization algorithm with neighborhood-based mutation for sequenee- dependent disassembly line balancing problem 显示文摘 | KALAYCI C B GUPTA S M | 2013 | The In- ternational Journal of Advanced Manufacturing Technology2013，30，4： | 1 |
| 11 | Artificial Bee Colony Algo- rithm for Solving Sequence-Dependent Disassembly Line Balancing Problem 显示文摘 | KALAYCI C B GUPTA S M | 2013 | Expert Systems with Applications2013，40，18： | 1 |
| 12 | Ant colony optimization for sequence-dependent disassembly line balancing problem 显示文摘 | KALAYCI C B GUPTA S M | 2013 | Journal of Manufacturing Technology Management2013，24，3： | 1 |
| 13 | Effect of losartan on the blood-brain barrier permeability in diabetic hypertensive rats显示文摘 | KAYA M KALAYCI R KüCüK M | 2003 | Life Sci2003，73，25： | 1 |
| 14 | Microbiology of bile in patients with cholangitis or cholestasis with and without plastic biliary endoprosthesis显示文摘 | Rerknimitr R Fogel EL Kalayci C | 2002 | Gastrointest Endosc2002，56，6： | 1 |
| 15 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia显示文摘 | Kaya M Gurses C Kalayci R | 2008 | Brain Res2008，1208，： | 1 |
| 16 | Microbiology of bile in patient s with cholangitis or cholestasis with and without plastic biliary endoprost hesis显示文摘 | Rerknimit R Fogel EL Kalayci C | 2002 | Gastrointestin Endosc2002，56，6： | 1 |
| 17 | Microbiology of bile in patients with cholangitis or cholestasis with and without plastic biliary endoprosthesis显示文摘 | Rerknimitr R Fogel E L Kalayci C | 2002 | Gastrointest Endosc2002，56，6： | 1 |
| 18 | Microbiology of bile in patients with cholangitis or cholestasis with and without plastic bilimary endoprosthesis显示文摘 | RERKNIMITR R FOGEL EL KALAYCI C | 2002 | Gastrointest Endose2002，56，： | 1 |
| 19 | Microbiology of bile in patients with cholangitis or cholestasis with and without plastic biliary endoprosthesis 显示文摘 | RerKnimitr R Fogel EL Kalayci C | 2002 | Gastrointestin Endose2002，56，6： | 1 |
| 20 | ALOX5 promoter genotype, asthma severity and LTC production by eosinophils显示文摘 | Kalayci O Birben E Sackesen C | 2006 | Allergy2006，61，1： | 1 |
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