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| 1 | Interaction of repaglinide with bovine serum albumin:Spectroscopic and molecular docking approaches显示文摘Repaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood. In view of its biological importance, we have examined the interaction between RPG and a model protein, bovine serum albumin (BSA) employing various spectroscopic, electrochemical and molecular docking methods. Fluorescence spectra of BSA were recorded in the presence and absence of RPG in phosphate buffer of pH 7.4. Fluorescence intensity of BSA was decreased upon the addition of increased concentrations of RPG, indicating the interaction between RPG and BSA. Stern-Volmer quenching analysis results revealed that RPG quenched the intensity of BSA through dynamic quenching mechanism. This was further confirmed from the time-resolved fluorescence measurements. The binding constant as calculated from the spectroscopic and voltammetric results was observed to be in the order of 104M-1 at 298 K, suggesting the moderate binding affinity between RPG and BSA. Competitive experimental results revealed that the primary binding site for RPG on BSA was site II. Absorption and circular dichroism studies indicated the changes in the secondary structure of BSA upon its interaction with RPG. Molecular simulation studies pointed out that RPG was bound to BSA in the hydrophobic pocket of site II. | Suma K.Pawar Seetharamappa Jaldappagari | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 2 |
| 2 | Dislodgement of bronchial foreign body during retrieval in children显示文摘 | Dilip K.Pawar | 2008 | Pediatric Anesthesia2008，，3： | 1 |
| 3 | 纺丝后处理对PET全拉伸丝性能的影响显示文摘纺丝后处理工艺对纤维牵伸后的强度和伸长率有显著影响。在恒定温度下,牵伸速率的变化会对纤维拉伸力学行为产生不同影响。当牵伸速率较低时,聚合物在牵伸力的作用下有足够的时间进行松弛并表现出微形变行为。随着牵伸速率的增大,纤维产生细颈形变从而使材料得以继续牵伸。当牵伸速率非常高时,材料来不及产生松弛,累积的弹性应力会导致其产生脆性断裂。按照相关标准设置牵伸工艺参数,然后通过改变牵伸力对牵伸工艺进行优化,并检查其对聚酯长丝强度和伸长率的影响。结果显示,随着牵伸力的增大,纤维强度从1.85 cN/dtex增大到2.58 cN/dtex,纤维伸长率则逐渐降低。 | K.Pawar R.Turukmane 王增效(译) | 2021 | 国际纺织导报2021，49，7： | 1 |
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