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| 1 | An Integrated Cyber-Physical Simulation Environment for Smart Grid Applications显示文摘The concept of Cyber-Physical Systems(CPSs),which combine computation,networking,and physical processes,is considered to be beneficial to smart grid applications. This study presents an integrated simulation environment to provide a unified platform for the investigation of smart grid applications involving power grid monitoring,communication,and control. In contrast to the existing approaches,this environment allows the network simulator to operate independently,importing its results to the power system simulation. This resolves conflicts between discrete event simulation and continuous simulation. In addition,several data compensation methods are proposed and investigated under different network delay conditions. A case study of wide-area monitoring and control is provided,and the efficiency of the proposed simulation framework has been evaluated based on the experimental results. | Yuxin Wan Junwei Cao Shuqing Zhang Guoyu Tu Chao Lu Xingtao Xu Keqin Li | 2014 | Tsinghua Science and Technology2014，19，2： | 13 |
| 2 | Some Investigations on Early Organization of Karst System显示文摘Some investigations on the early organization of karst system are carried out through modeling the dissolution evolution processes of stochastic fracture networks in carbonate rock. It is assumed that water flow in fracture network is laminar, and the dissolution rate process can be described with an empirical equation, The results suggest that a karst system is a self-organization system. It can spontaneously create higher hierarchical level out of a relative homogeneous structure through amplifying the microscopic heterogeneity of initial flow field. Under given boundary conditions, a karst system with initial fracture network of varied hierarchical levels is likely to have stronger tendency to lead to a typical karst system featuring conduit passages than a system with initial network of unique hierarchical level. Through merging local flow systems, a karst system concentrates the limited flow into a few pathways to promote the formation of higher hierarchical level. | Yu Qingchun(Geofront Laboratory, Department of Civil Engineering, Kyoto University, Kyoto 606-8501, Japan)Shen Jifang Wan Junwei(Department of Hydrogeology and Environmental Engineering, China University of Geosciences,Wuhan 430074, China)Ohnishi Yuzo(Geo | 1999 | Journal of Earth Science1999，18，4： | 8 |
| 3 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 4 | QoS-Aware Virtual Machine Scheduling for Video Streaming Services in Multi-Cloud显示文摘Video streaming services are trending to be deployed on cloud. Cloud computing offers better stability and lower price than traditional IT facilities. Huge storage capacity is essential for video streaming service. More and more cloud providers appear so there are increasing cloud platforms to choose. A better choice is to use more than one data center, which is called multi-cloud. In this paper a closed-loop approach is proposed for optimizing Quality of Service (QoS) and cost. Modules of monitoring and controlling data centers are required as well as the application feedback such as video streaming services. An algorithm is proposed to help choose cloud providers and data centers in a multi-cloud environment as a video service manager. Performance with different video service workloads are evaluated. Compared with using only one cloud provider, dynamically deploying services in multi-cloud is better in aspects of both cost and QoS. If cloud service costs are different among data centers, the algorithm will help make choices to lower the cost and keep a high QoS. | Wei Chen Junwei Cao Yuxin Wan | 2013 | Tsinghua Science and Technology2013，18，3： | 3 |
| 5 | RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C.elegans显示文摘The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis.RAB-27/AEX-6,but not RAB-3,was found to be required for peptide release from neurons.By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy,we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking. | FENG Wan Juan LIANG Tao YU JunWei ZHOU Wei ZHANG YongDeng WU ZhengXing XU Tao | 2012 | Science China(Life Sciences)2012，55，3： | 1 |
| 6 | Extraction of theanine from waste liquid of tea polyphenol production in aqueous two-phase systems with cationic and anionic surfactants显示文摘 | Junwei Zhang Yan Wan | 2013 | Chin J Chem Eng2013，21，1： | 1 |
| 7 | Theoretical and Experimental Studies of Coupled Seepage-Pipe Flow to a Horizontal Well 显示文摘 | Chen Chongxi Wan Junwei Zhan Hongbin | 2003 | Journal of Hydrology2003，281，12： | 1 |
| 8 | Performance Modeling for Data Monitoring Services in Smart Grid: A Network Calculus Based Approach显示文摘This paper focuses on solving the modeling issues of monitoring system service performance based on the network calculus theory.First,we formulate the service model of the smart grid monitoring system.Then,we derive the flow arrival curve based on the incremental process related functions.Next,we develop flow arrival curves for the case of the incremental process being a fractional Gaussian process,and then we obtain the generalized Cauchy process.Three technical theorems related to network calculus are presented as our main results.Mathematically,the variance of arrival flow for the continuous time case is derived.Assuming that the incremental process of network flow is a Gaussian stationary process,and given the auto-correlation function of the incremental process with violation probability,the formula of the arrival curve is derived.In addition,the overall flow variance under the discrete time case is explicitly derived.The theoretical results are evaluated in smart grid applications.Simulations indicate that the generalized Cauchy process outperforms the fractional Gaussian process for our considered problem. | Junwei Cao Yuxin Wan Haochen Hua Gang Yang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 1 |
| 9 | Influences of Water Conservancy and Hydropower Projects on Runoff in Qingjiang River Upstream Basin显示文摘Hydrological data on the Upper Qingjiang River from 1960 to 2012 document trends of runoff caused by hydropower engineering projects and long-term changes in rainfall. Annual runoff correlates strongly with annual precipitation, but is significantly reduced after reservoir construction compared to earlier values. Comparisons of intense, pre- and post-construction rainfall events suggest that the Chebahe and Dalongtan reservoir projects respectively clips the magnitude of the flood peaks and delays runoff delivery. | Yi Sun Junwei Wan Songyuan Yang Xinghua Xue Kun Huang | 2016 | Journal of Earth Science2016，27，1： | 0 |
| 10 | Emulation of auditory senses depending on chaotic dynamics of threshold switching memristor显示文摘Emulating the auditory sense is a significant challenge in terms of both integration and energy consumption for handling complicated spatiotemporal information.Here,we demonstrate how to utilize the chaotic dynamics of a threshold switching memristor,which usually acts as a leaky integrate and fire neuron in the neuromorphic network,to encode the frequency and amplitude in auditory information.We fabricate a Pd/Nb/NbOx/Nb/Pd memristor domi-nated by the Poole-Frankel conduction mechanism,set its state at the edge of chaos,and stimulate it using periodic perturbations.The memristor's responses to the perturbation frequencies can be categorized into three zones.Two are phase locking with linear phase-frequency rela tionships,and one has a hyper-bolic spike number-frequency relationship.The memristor system also enables intensity coding and tonotopy by modulating the response spikes in either the locked phase or spike number.Based on the emulation of these two features,the memristor system demonstrates sound location and frequency mixing.Our study suggests a novel routine for handling the auditory and visual senses using threshold-switching memristor arrays to enhance the efficiency of neuromorphic networks. | Junwei Yu Fei Zeng Qin Wan Ziao Lu Feng Pan | 2023 | InfoMat2023，5，10： | 0 |
| 11 | Memristive structure of Nb/HfOx/Pd with controllable switching mechanisms to perform featured actions in neuromorphic networks显示文摘All memristor neuromorphic networks have great potential and advantage in both technology and computational protocols for artificial intelligence.It is crucial to find suitable elementary units for both performing featured neuromorphic functions and fabrication in large scale.Here a simple memristive structure,Nb/HfOx/Pd,is proposed for this goal.Its two resistive switching mechanisms,Mott transition of NbO2 and oxygen vacancy(Vo)migration,can be controlled by modulating external bias directions.Negative bias activates reversible phase transition and restrains Vo filament formation to allow the memristor to mimic the firing action potential.Positive bias activates Vo filament formation and restrains the other to allow the memristor to mimic synaptic plasticity and learning protocols.The system can respond adaptively to naturally generated action potentials and modified synaptic signals from the same memristive structure.In addition,some special features related to signal encoding and recognition are discovered when the system is settled according to chaos circuit theory.Our study provides a novel approach for designing elementary units for neuromorphic computations. | Junwei Yu Fei Zeng Qin Wan Yiming Sun Leilei Qiao Tongjin Chen Huaqiang Wu Zhen Zhao Jiangli Cao Feng Pan | 2022 | Nano Research2022，15，9： | 0 |
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