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| 1 | Epigenetic mechanisms involved in developmental nutritional programming显示文摘The ways in which epigenetic modifications fix the effects of early environmental events,ensuring sustained responses to transient stimuli,which result in modified gene expression patterns and phenotypes later in life,is a topic of considerable interest.This review focuses on recently discovered mechanisms and calls into question prevailing views about the dynamics,position and functions of epigenetic marks.Most epigenetic studies have addressed the long-term effects on a small number of epigenetic marks,at the global or individual gene level,of environmental stressors in humans and animal models.In parallel,increasing numbers of studies based on high-throughput technologies and focusing on humans and mice have revealed additional complexity in epigenetic processes,by highlighting the importance of crosstalk between the different epigenetic marks.A number of studies focusing on the developmental origin of health and disease and metabolic programming have identified links between early nutrition,epigenetic processes and long-term illness.The existence of a self-propagating epigenetic cycle has been demonstrated.Moreover,recent studies demonstrate an obvious sexual dimorphism both for programming trajectories and in response to the same environmental insult.Despite recent progress,we are still far from understanding how,when and where environmental stressors disturb key epigenetic mechanisms.Thus,identifying the original key marks and their changes throughout development during an individual's lifetime or over several generations remains a challenging issue. | Anne Gabory Linda Attig Claudine Junien | 2011 | World Journal of Diabetes2011，2，10： | 2 |
| 2 | The genetics of neonatal hyperinsulinism显示文摘 | Fournet JC Junien C | 2003 | HormRes2003，59，1： | 1 |
| 3 | Sexual dimorphism in environmental epigenetie programming显示文摘 | Gabory A Attig L Junien C | 2009 | Mol Cell Endocrinol2009，304，12： | 1 |
| 4 | Developmental programming and epigenetics显示文摘 | Gabory A Attig L Junien C | | 0，，6： | 1 |
| 5 | Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic 显示文摘 | Gallou-Kabani C Junien C | 2005 | Diabetes2005，54，7： | 1 |
| 6 | Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors显示文摘 | Lagente V Pruniaux MP Junien JL | 1995 | Am J Respir Crit Care Med1995，151，： | 1 |
| 7 | The effect of morphine and nalorphine like drugs in the non-dependent and morphin depedent chronic spinaldog 显示文摘 | Martin WR Harris R Junien J | 1976 | J Pharmacol Exp Therap1976，197，： | 1 |
| 8 | Modulation of cytokine-induced eosinophil infiltration by phosphodiesterase inhibitors显示文摘 | | 1995 | Am J Respir Crit Care Med1995，151，61： | 1 |
| 9 | Report on the IASO Stock Conference 2006:early and lifelong environmental epigenomic programming of metabolic syndrome,obesity and type Ⅱ diabetes显示文摘 | Junien C Nathanielsz P | | 0，，6： | 1 |
| 10 | Central nervous system pharmacology of neuropeptide Y显示文摘 | WETTSTEIN J G EARLEY B JUNIEN J L | 1995 | Pharmacology and Therapeutics1995，65，3： | 1 |
| 11 | Genetics of congential hyperinsulinism显示文摘 | FOURNET JC JUNIEN C | 2004 | Endor Pathol2004，15，3： | 1 |
| 12 | Report on the IASO Stock Conference 2006 : early and lifelong environmental epigenomic programming of metabolic syndrome, obesity and type I] diabetes 显示文摘 | Junien C Nathanielsz P | 2007 | Obes Rev2007，8，6： | 1 |
| 13 | Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic 显示文摘 | Gallou-Kabani C Junien C | 2005 | Diabetes2005，54，7： | 1 |
| 14 | Epigeneties, interface between environment and genes: role in complex diseases显示文摘 | Scheen AJ Junien C | 2012 | Rev Med Liege2012，67，56： | 1 |
| 15 | Nutritional epigenomics of metabolic syndrome: new perspective against the epidemic 显示文摘 | Callou-Kabani C Junien C | 2005 | Diabetes2005，54，7： | 1 |
| 16 | Conditioned emotional response in rats enhances colonic motility through the central release of corticotrophin-releasing factor 显示文摘 | Gue M Junien JL Bueno L | 1991 | Gastroenterology1991，100，4： | 1 |
| 17 | The genetics of neonatal hyperinsulinism 显示文摘 | Fournet JC Junien C | 2003 | Horm Res2003，59，1： | 1 |
| 18 | Impact of diets and nutrients/drugs on early epigenetic programming显示文摘 | Junien C | 2006 | J Inherit Metab Dis2006，29，23： | 1 |
| 19 | Report of the committee on chromosome and gene loss in human neoplasia显示文摘 | Seizinger BR Klinger HP Junien C | 1991 | Cytogenet Cell Genet1991，58，34： | 1 |
| 20 | Conditioned emotional response in rats enhances colonic motility through the central release of corti- cotropin - releasing factor 显示文摘 | Gue M Junien JL Bueno L | 1991 | Gastroenterology1991，100，： | 1 |
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