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| 1 | Soluble Mouse B7-H3 Down-Regulates Dendritic Cell Stimulatory Capacity to Allogenic T Cell Proliferation and Production of IL-2 and IFN-γ显示文摘B7-H3 是 B7 基因家庭的一个最近识别的成员。它的无所不在的表示在淋巴并且 nonlymphoid 纸巾建议它能在自我忍耐的维护起一个重要作用。然而, B7-H3 的准确功能仍然是逃犯的。当前的学习的目的是为调停 DC 的 T 房间激活的预防表明可溶的老鼠 B7-H3 的可能的功能。为这个目的,我们建立了可溶的老鼠 B7-H3 熔化蛋白质(mB7h3-hIg ) 有 C 终端人的 IgG1 Fc 的真核细胞的表示向量(pmB7h3-hIg ) 。C57BL/6 (B6 ) 导出树枝状的房间线(DC2.4 房间) 为可溶的 mB7h3-hIg 的产生被用于稳定的 transfectants 的建立。宫外的 mB7h3-hIg 表示被 RT-PCR,西方的污点和 ELISA 分析证实。49.7 kD 蛋白质被西方的污点与 pmB7h3-hIg 从 DC2.4 房间 transfected 检测。可溶的 mB7h3-hIg 表示没在房间骑车和 apoptosis 和 CD80 的表示和 DC2.4 房间的 CD86 上有效果,这被发现。然而,宫外的可溶的 mB7h3-hIg 表示被发现显著地为 DC2.4 房间影响 allo-stimulatory 能力。当与 MLC.Further 决定的控制相比研究表明可溶的 mB7h3-hIg 能也禁止 IL-2 和建议的 allogenic T cells.These 结果的 IFN- 生产,表示可溶的 mB7h3-hIg 的 DC2.4 房间显示出一个重要减少的 allo-stimulatory 能力为接枝拒绝和 autoimmume 疾病的治疗的可溶的 B7-H3 的一个大潜力。 | Junfa Xu Baojun Huang Ping Xiong Wei Feng Yong Xu Min Fang Fang Zheng Feili Gong | 2006 | Cellular & Molecular Immunology2006，3，3： | 8 |
| 2 | Voussoir beam model for lower strong roof strata movement in longwall mining - Case study显示文摘The paper presents the influence of varying immediate roof thickness on the lower strong roof strata movement and failure pattern in longwall coal mining with large mining height. The investigation is based on 58 geological drill holes and hydraulic shield pressure measurements around the longwall Panel 42105 of the Buertai Mine in Inner Mongolia Autonomous Region, China. The longwall Panel 42105 is characterized by relatively soft immediate roof strata of varying thickness superposed by strong strata,herein defined as lower strong roof. A voussoir beam model is adopted to interpret the structural movement of the lower strong roof strata and shield pressure measurements. It is shown that when the immediate roof is relatively thick, the broken overlying lower strong roof tends to form a stable voussoir beam with previously broken layer, thus not exerting high pressure on the hydraulic shield and working face. When the immediate roof is relatively thin, the broken overlying lower strong roof tends to behave as a cantilever beam, thus exerting higher pressure on the hydraulic shield and working face. Comparison of model predictions with measured time-weighted average shield pressure(TWAP) shows good agreement. | Chuang Liu Huamin Li Hani Mitri Dongjie Jiang Huigui Li Junfa Feng | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，6： | 5 |
| 3 | Electronic structure and chemical reaction of Ca deposition on regioregular poly(3-hexylthiophene) surfaces显示文摘Conjugated polymer, regioregular poly(3-hexylthiophene) (rr-P3HT), films were prepared by spin-coating the rr-P3HT chloroform solution onto clean silicon wafer surfaces. The chemical re-action and electronic structure of Ca deposition on rr-P3HT surfaces were in situ investigated by synchrotron radiation photoemission spectroscopy (SRPES) and X-ray photoemission spectros-copy (XPS). Upon Ca deposition, Ca-induced band bending of rr-P3HT is observed. In addition, Ca atoms preferentially react with S atoms of rr-P3HT. No obvious reaction between Ca and C atoms can be found. Through the investigation of the evolution of valence band spectra and secondary electron cut-off of rr-P3HT during the process of Ca deposition, an energy level alignment diagram at the Ca/rr-P3HT interface is derived. | ZHAO Wei GUO YuXian FENG XueFei ZHANG Liang ZHANG WenHua ZHU JunFa | 2009 | Chinese Science Bulletin2009，54，11： | 3 |
| 4 | Improved preparation and identification of aristolochic acid-DNA adducts by solid-phase extraction with liquid chromatography-tandem mass spectrometry显示文摘Aristolochic acid (AA) is a known nephrotoxin and potential carcinogen, which can form covalent DNA adducts after metabolic activation in vivo and in vitro. A simple method for preparation and characterization of aristolochic acid-DNA adducts was developed. Four AA-adducts were synthesized by a direct reaction of AAI/AAII with 2'-deoxynucleosides. The reaction mixture was first cleaned-up and pre-concentrated using solid phase extraction (SPE), and further purified by a reversed-phase high performance liquid chromatography (HPLC). By the application of developed SPE procedure, matrices and byproducts in reaction mixture could be greatly reduced and adducts of high purity (more than 94% as indicated by HPLC) were obtained. The purified AA-DNA adducts were identified and characterized with liquid-electrospray ionization-quadrupole-time of flight-mass spectrometry (LC-ESI-Q-TOF-MS/MS) and LC-Diode array detector-fluorescence (LC-DAD-FL) analysis. This work provides a robust tool for possible large-scale preparation of AA-DNA adduct standards, which can promote the further studies on carcinogenic and mutagenic mechanism of aristolochic acids. | GAO Haiyan GUO Fangqiu FENG Feng YIN Junfa SONG Maoyong WANG Hailin | 2009 | Journal of Environmental Sciences2009，21，12： | 0 |
| 5 | Application of Arthroscopic Technology in the Treatment of Traumatic Sports Ankle Arthritis显示文摘Objective:To analyze and explore the clinical value of arthroscopy in traumatic sports ankle arthritis.Methods:The study period was from June 2016 to June 2020.A selected sample of 25 patients with traumatic sports ankle arthritis in Qingyang People's Hospital were treated.All patients underwent arthroscopy and the specific treatment effects were analyzed.Results:Comparing the preoperative and postoperative ankle-hindfoot scores,the distance of talus advancement,modified Mcguire's ankle scoring system,and visual analog scale(VAS)pain scores,the postoperative results were significantly better than those of the preoperative(P<0.05).Conclusion:Arthroscopy in traumatic sports ankle arthritis has a significant effect,with minor trauma and rapid postoperative recovery which improves various discomfort symptoms.It is worthy of promotion and application. | Junfa Dang Xiaohu Sun Wei Feng Jun Yang | 2021 | Journal of Clinical and Nursing Research2021，5，4： | 0 |
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