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| 1 | Oxidative stress and stress signaling: menace of diabetic cardiomyopathy显示文摘心血管的疾病是在糖尿病的人口的最普通的死因并且当前是在美国和另外的工业化国家的死亡的领先的原因之一。与心血管的疾病联系的护理开销正在蹒跚,到达在 2003 的超过 3500 亿美元。为心血管的疾病的风险因素包括高脂肪 / 胆固醇的层次,酒精中毒,吸烟,遗传,环境因素和高血压,它通常被用来计量一个个人心血管的疾病的风险并且在治疗期间追踪他们的进步。最最近,这些因素在心血管的疾病的早预防变得重要。氧化应力,在由内长的抗氧化剂的反应的氧种类生产和故障之间的不平衡,在象充血心力衰竭和联系糖尿病的心机能障碍(糖尿病的心肌症) 那样的心血管的疾病的发作和前进被含有。抗氧化剂治疗在阻止糖尿病的心复杂并发症的发展显示出诺言。这评论在糖尿病的心肌症在氧化压力理论和抗氧化剂治疗集中于最近的进展,与表明假设被涉及的小径的压力上的一个重音。许多表明小径的这些压力导致反应的氧种类的激活,在糖尿病的心肌症的发展和前进的主要播放器。 | Loren E WOLD Asli F CEYLAN-ISIK Jun REN | 2005 | Acta Pharmacologica Sinica2005，26，8： | 23 |
| 2 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 3 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 4 | Interobserver agreement for contrast-enhanced ultrasound of liver imaging reporting and data system:A systematic review and metaanalysis显示文摘BACKGROUND Hepatocellular carcinoma is the most common primary liver malignancy.From the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisfactory diagnostic value.However,a unified conclusion on the interobserver stability of this innovative ultrasound imaging has not been determined.The present metaanalysis examined the interobserver agreement of CEUS LI-RADS to provide some reference for subsequent related research.AIM To evaluate the interobserver agreement of LI-RADS on CEUS and analyze the sources of heterogeneity between studies.METHODS Relevant papers on the subject of interobserver agreement on CEUS LI-RADS published before March 1,2020 in China and other countries were analyzed.The studies were filtered,and the diagnostic criteria were evaluated.The selected references were analyzed using the“meta”and“metafor”packages of R software version 3.6.2.RESULTS Eight studies were ultimately included in the present analysis.Meta-analysis results revealed that the summary Kappa value of included studies was 0.76[95%confidence interval,0.67-0.83],which shows substantial agreement.Higgins I2 statistics also confirmed the substantial heterogeneity(I2=91.30%,95%confidence interval,85.3%-94.9%,P<0.01).Meta-regression identified the variables,including the method of patient enrollment,method of consistency testing,and patient race,which explained the substantial study heterogeneity.CONCLUSION CEUS LI-RADS demonstrated overall substantial interobserver agreement,but heterogeneous results between studies were also obvious.Further clinical investigations should consider a modified recommendation about the experimental design. | Jun Li Ming Chen Zi-Jing Wang Shu-Gang Li Meng Jiang Long Shi Chun-Li Cao Tian Sang Xin-Wu Cui Christoph F Dietrich | 2020 | World Journal of Clinical Cases2020，8，22： | 2 |
| 5 | Cytokines in Mycoplasma pneumoniae infections显示文摘 | Jun Yang W.Craig Hooper Donald J Phillips Deborah F Talkington | 2003 | Cytokine and Growth Factor Reviews2003，，2： | 2 |
| 6 | Reproducing kernel particle methods 显示文摘 | LIU W K JUN S ZGABG Y F | 1995 | International Journal for Numerical Methods in Fluids1995，20，： | 1 |
| 7 | Inaccuracy and misjudged fac- tors of Glasgow Coma Scale scores when assessed by inexperiencedphysicians显示文摘 | Jun N Motoyasu Y Tomohiro F | 2011 | Clinical Neurology and Neurosurgery2011，113，5： | 1 |
| 8 | Soft semirings显示文摘 | Feng F Jun Y B Zhao X Z | 2008 | Computers and Mathematics with Applications2008，56，10： | 1 |
| 9 | An Adjustable Approach to Fuzzy Soft Set Based Decision Making显示文摘 | Feng F Jun Y B Liu X | 2010 | Computational and Applied Mathe- matics2010，234，1： | 1 |
| 10 | *-λ-semiring and*-μ-semiring显示文摘 | Feng F Zhao X Z Jun Y B | 2005 | Theoretical Compute Science2005，，347： | 1 |
| 11 | Reproducing kernel Particle methods显示文摘 | LIU W K JUN S ZHANG Y F | 1995 | International Journal for Numerical Methods in Fluids1995，，20： | 1 |
| 12 | Amniotic fluid cytokines ( interleukin-6, tumor necrosis factoralpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia显示文摘 | Yoon BH Romero R Jun JK Park KH Park JD Ghezzi F | 1997 | Am J Obstet Gynecol1997，177，4： | 1 |
| 13 | Atrial extracellular matrix remodeling and the maintenance of atrial fibrillation 显示文摘 | Xu Jun Cui Guanggen Esmailian F | 2004 | Circulation2004，109，3： | 1 |
| 14 | A novel motion control de- sign approach based on active disturbance rejection显示文摘 | Q z Gao HS Hu J F Jun | 2001 | IEEE Conference on Decision and Control2001，12，5： | 1 |
| 15 | On*-λ-semiring显示文摘 | Feng F Zhao X Z Jun Y B | 2007 | Information Sciences2007，，177： | 1 |
| 16 | Reproducing kernel particle methods 显示文摘 | Liu W K Jun S Zhang Y F | 1995 | Int J Numer Meth Fluids1995，20，： | 1 |
| 17 | Inaccuracy and misjudged fac- tors of Glasgow Coma Scale scores when assessed by inexperienced physicians显示文摘 | Jun N Motoyasu Y Tomohiro F | 2011 | Clinical Neurology and Neurosurgery2011，113，5： | 1 |
| 18 | Gene delivery using a receptor- mediated gene transfar system targeted to hepatocellular Carcinoma Cells 显示文摘 | Jun - Song H Sheung - Tot F | 2001 | Int J cancer2001，93，： | 1 |
| 19 | Law, finance and economic growth in China 显示文摘 | Allen F Jun Qian Qian Meijun | 2005 | Journal of Financial Economics2005，77，1： | 1 |
| 20 | Mi- crofluidic cell separation by 2-dimensional dielectro- phoresis 显示文摘 | de Gasperis G Yang Jun Becker F F | 1999 | Biomedical Microdevices1999，2，1： | 1 |
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