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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Evaluation of pharyngeal airway space amongst different skeletal patterns显示文摘 | Alves M Jr Franzotti ES Baratieri C | 2012 | Int J Oral Max- illofac Surg2012，41，7： | 1 |
| 3 | Assessment of mini-implant displacement using cone beam com- puted tomography显示文摘 | Alves M Jr Baratieri C Nojima LI | 2011 | Clin Oral Implants Res2011，22，10： | 1 |
| 4 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Jr ALVES C GUERRA NETO C L B MORAIS G H S | 2006 | Surface and Coatings Technology2006，200，： | 1 |
| 5 | Analytical so- lution of single screw extrusion applicable to intermediate values of screw channel aspect ratio显示文摘 | Alves M V C Barbosa Jr J R Prata A T | 2009 | Journal of Food Engineering2009，92，2： | 1 |
| 6 | Layout optimization with h-adaptivity of structures 显示文摘 | Arantes Costa Jr J C Alves M K | 2003 | International Journal for Numerical Methods in Engineering2003，58，1： | 1 |
| 7 | Evaluation of pharyngeal airway space amongst different skeletal patterns显示文摘 | Alves M Jr Franzotti ES Baratieri C | 2012 | Int J Oral Maxillofac Surg2012，41，7： | 1 |
| 8 | Postharvestcontrol of brown rot and Rhizopus rot in plums and nectarines using carnaubawax显示文摘 | GON?ALVES F P MARTINS M C Jr SILVA G J | 2010 | Postharvest Biology and Technology2010，58，： | 1 |
| 9 | Analysis of oil pumping in a reciprocating compressor 显示文摘 | Antonio J Luckmann Marcus Vinieius C Alves Jader R Barbo- sa Jr | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 10 | Deposition of TiO2 on silicon by sputtering in hollow cathode 显示文摘 | De Aratjo F O De AlmeidaE O Alves Jr C | 2006 | Surface and Coatings Technology2006，201，6： | 1 |
| 11 | Effects of gas composition during plasma modification of polyester fabrics 显示文摘 | Costa T H C Feito M C Jr Alves C | 2006 | Journal of Materials Processing Technology2006，173，： | 1 |
| 12 | 查看详情显示文摘 | Sinka V Alves Jr C Janák G | | 0，，： | 1 |
| 13 | Use of cathodic cage in plasma nitriding显示文摘 | Alves Jr C Aranio F O de Ribeiro K J B | 2006 | Surface and Coatings Technology2006，201，6： | 1 |
| 14 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Alves Jr C Guerra Nero C L B Morais G H S Silva da C F I-Iajek V | 2005 | Surface & Coatings Technology2005，194，： | 1 |
| 15 | Effects of gas composition during plasma modification of polyester fabrics显示文摘 | Costa T H C Feitor M C Alves Jr C | 2006 | Journal of Materials Processing Technology2006，173，： | 1 |
| 16 | Assessment of mini-implant displacement using cone beam com- puted tomography显示文摘 | Alves M Jr Baratieri C Nojima LI | 2011 | Clin Oral Implants Res2011，22，10： | 1 |
| 17 | Thermal behavior of supersolidus bronze powder compacts during heating by hollow cathode discharge 显示文摘 | Alves Jr C Hajek V dos Santos C A | 2003 | Materials Science and Engineering2003，348，12： | 1 |
| 18 | Thermal behavior of supersolidus bronze powder compacts during heatingby hollow cathode discharge 显示文摘 | Alves Jr C Hajek V dos Santos C A | 2003 | Materials Science and Engineering2003，348，12： | 1 |
| 19 | Evaluation of pharyngeal airway space amongst different skeletal patterns 显示文摘 | Alves M Jr Franzotti ES Baratieri C | 2012 | Int J Oral Maxillofac Surg2012，41，7： | 1 |
| 20 | Effects during plasma nitriding of shaped materials of different sizes显示文摘 | Ataíde de A R P Alves Jr Jr C Hajek V | 2003 | Surf Coat Techn2003，167，1： | 1 |
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