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14篇 您的检索式：作者名="Joseph TC"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	Glutamate and schizophrenia:Beyond the dopamine hypothesis显示文摘	Joseph TC	2006	Cell Mol Neurobiol2006，26，46：	1
	3	Molecular typing of Vibrio parahaemolytieus strains isolated from Marine finfishshellfish landed along south-west coast of India显示文摘	Chakraborty RD Surendran PK Joseph TC	2013	Indian J Fish2013，60，1：	1
	4	N-Phenyl-1H-pyrrolederivatives are angiotensin Ⅱ receptor antagonists显示文摘	Phillpe RB David BR Joseph TC	1993	J Med Chem1993，36，1：	1
	5	Serious Ocular Complications of Zoledronate 显示文摘	Woo TC Joseph DJ Wilkinson R	2006	Clin Oncol2006，18，7：	1
	6	Alzheimer's disease: a disorder of cortical cholinergic innervation显示文摘	Joseph TC Donald LP Mahlon RD	1983	Science1983，219，：	1
	7	Hyperbaric oxygen treatment for radiation proctitis显示文摘	Woo TC Joseph D Oxer H	1997	Int J Radiat Oneol Biol Phys1997，38，3：	1
	8	The effect of weight loss surgery and body mass index on wound complications after contouring operations显示文摘	Joseph G Eric TC Lillian N	2008	Ann Plast Surg2008，61，3：	1
	9	Treatment of an osteoporotie Hoffa fracture 显示文摘	Joseph J Hsi TC Jason CHF	2010	Knee Surgery Sports Traumatology Arthroseopy2010，18，6：	1
	10	Temperature and pH affect transglutaminase-catalyzed 'setting' of crude fish actomyosin显示文摘	JOSEPH D LANIER TC HAMANN DD	1994	Journal of Food Science1994，，59：	1
	11	Alzheimer's disease: a disorder of cortical cholinergic innervation显示文摘	Joseph TC Donald LP Mahlon RD	1983	Science1983，219，：	1
	12	Temperature and p H effect transglutaminase catalyzed setting of crude fish actomyosin显示文摘	JOSEPH D LANIER TC HAMANN DD	1994	Journal of Food Science1994，59，5：	1
	13	Hyperbaric oxygen treatment for radiation proctitis显示文摘	Wo TC Joseph D Oxer H	1997	Int J Radiat Oncol Biol Phys1997，38，3：	1
	14	Injection drug use and HIV/AIDS in China: review of current situation, prevention and policy implications 显示文摘	Han-Zhu Q Joseph ES Huey TC	2006	Harm Reduction Journal2006，3，：	1

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