| 1 | 软骨寡聚基质蛋白在慢性胰腺炎损伤中退变腺泡细胞内的表达显示文摘目的 研究正常胰腺、慢性胰腺炎与胰腺癌组织中软骨寡聚基质蛋白 (cartilageoligomericmatrixprotein ,COMP)mRNA和蛋白表达水平的差异 ,揭示COMP在慢性胰腺炎样损伤中的意义。 方法 采用Northern印迹法、Western印迹法、原位杂交法与免疫组化方法对 14例慢性胰腺炎、14例胰腺癌及 15例正常胰腺组织进行分析。 结果 在慢性胰腺炎组织中和胰腺癌组织中类似慢性胰腺炎损伤的退变腺泡细胞胞浆内 ,存在高水平的COMPmRNA信号与免疫反应 ;而在胰腺癌细胞、正常胰腺组织的导管细胞与胰岛细胞的胞浆内 ,COMPmRNA信号与免疫反应微弱或缺如。结论 COMP在慢性胰腺炎及胰腺癌中类似慢性胰腺炎损伤的退变腺泡细胞内高表达 ,可能与慢性胰腺炎中腺泡细胞功能异常有关。 | 廖泉 赵玉沛 Jorg Kleeff 肖毅 Arthur Zimmermann Markus W.Buchler Helmut Friess | 2003 | 中华外科杂志2003，41，5： | 2 |
| 4 | Modelling the long-term geomorphic response to check dam failures in an alpine channel with CAESAR-Lisflood显示文摘Globally,between 1950 and 2011 nearly 80,000 debris flow fatalities occurred in densely populated regions in mountainous terrain.Mitigation of these hazards includes the construction of check dams,which limit coarse sediment transport and in the European Alps number in the 100,000s.Check dam functionality depends on periodic,costly maintenance,but maintenance is not always possible and check dams often fail.As such,there is a need to quantify the long-term(10-100 years)geomorphic response of rivers to check dam failures.Here,for the first time,a landscape evolution model(CAESARLisflood)driven by a weather generator is used to replicate check dam failures due to the lack of maintenance,check dam age,and flood occurrence.The model is applied to the Guerbe River,Switzerland,a pre-Alpine catchment containing 73 check dams that undergo simulated failure.Also presented is a novel method to calibrate CAESAR-Lisflood's hydrological component on this ungauged catchment.Using 100-year scenarios of check dam failure,the model indicates that check dam failures can produce 8 m of channel erosion and a 322%increase in sediment yield.The model suggests that after check dam failure,channel erosion is the remobilization of deposits accumulated behind check dams,and,after a single check dam failure channel equilibrium occurs in five years,but after many check dam failures channel equilibrium may not occur until 15 years.Overall,these findings support the continued maintenance of check dams. | Jorge Alberto Ramirez Mirjam Mertin Nadav Peleg Pascal Horton Chris Skinner Markus Zimmermann Margreth Keiler | 2022 | International Journal of Sediment Research2022，37，5： | 1 |
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