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3篇 您的检索式：作者名="Jonathan Watkins"

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		题名	作者	年代	出处	被引量
	1	Displacement Control of a Beam Using Photostrictive Optical Actuators 显示文摘	Hui-Ru Shih Jonathan Watkins Horn-Sen Tzou	2005	Journal of Intelligent Material Systems and Structures2005，，16：	1
	2	Validation of Magnetic Resonance Myocardial Perfusion Imaging With Fractional Flow Reserve for the Detection of Significant Coronary Heart Disease显示文摘	Stuart Watkins Ross McGeoch Jonathan Lyne Tracey Steedman Richard Good Mairi-Jean McLaughlin Tony Cunningham Vladimir Bezlyak Ian Ford Henry J. Dargie Keith G. Oldroyd	2009	Circulation2009，，22：	1
	3	Antimicrobial activity of PVP from an Antarctic bacterium, Janthinobacterium sp. Ant5-2, on multi-drug and methicillin resistant Staphylococcus aureus显示文摘Multiple drug resistant(MDR)and methicillin-resistant Staphylococcus aureus(MRSA)have become increasingly prevalent as a community acquired infection.As a result limited treatment options are available with conventional synthetic antibiotics.Bioprospecting natural products with potent antimicrobial activity show promise for developing new drugs against this pathogen.In this study,we have investigated the antimicrobial activity of a purple violet pigment(PVP)from an Antarctic bacterium,Janthinobacterium sp.Ant5-2 on 15 clinical MDR and MRSA strains.The colorimetric resazurin assay was employed to determine the minimum inhibitory concentration(MIC90)of PVP against MDR and MRSA.The MIC90 ranged between 1.57μg/mL and 3.13μg/mL,which are significantly lower than many antimicrobials tested from natural sources against this pathogen.The spectrophotometrically determined growth analysis and total microscopic counts using Live/dead®BacLight™fluorescent stain exhibited a steady decrease in viability of both MDR and MRSA cultures following treatment with PVP at the MIC levels.In silico predictive molecular docking study revealed that PVP could be a DNA-targeting minor groove binding antimicrobial compound.The continued development of novel antimicrobials derived from natural sources with the combination of a suite of conventional antibiotics could stem the rising pandemic of MDR and MRSA along with other deadly microbial pathogens.	Jonathan P.HUANG Nazia MOJIB Rakesh R.GOLI Samantha WATKINS Ken B.WAITES Rasik RAVINDRA Dale T.ANDERSEN Asim K.BEJ	2012	Natural Products and Bioprospecting2012，2，3：	0

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