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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis显示文摘AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.RESULTS Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high CRC.CONCLUSION Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4. | Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis David J Hughes Ana Elizabete Silva | 2018 | World Journal of Gastroenterology2018，24，47： | 15 |
| 3 | Evaluation of estrogen receptor α and β and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki- 67 in breast cancers显示文摘 | Fabiola E R Jose R F C Joice F | 2008 | Human Pathology2008，39，5： | 1 |
| 4 | Predicting health related quality of life 6 months after stroke : the role of anxiety and upper limb dysfunction 显示文摘 | Morris JH van Wijck F Joice S | 2013 | Disabil Rehabil2013，35，4： | 1 |
| 5 | Adaptive relaying-a new direction in power system protection 显示文摘 | CODLING J D HOUSE S A JOICE J H | 1996 | IEEE Potentials1996，15，1： | 1 |
| 6 | Cytokerin 20 expression by non-invasive transitional cell carcinomas: potential for distinguishing recurrent from non-recurrent disease 显示文摘 | Harnden P Allen A Joice AD | 1995 | Histopathology1995，27，： | 1 |
| 7 | Digital Control Strategy for Four Quadrant Operation of Three Phase BLDC Motor with Load Variations显示文摘 | Sheeba Joice C Paranjothi S R Senthil Kumar V J | 2012 | IEEE Trans Ind Inform2012，，5： | 1 |
| 8 | Antimierobial resistance and genetic diversity of Escherichia coli isolated from humans and foods 显示文摘 | Daniela Benevides Mdo Aria Paula de Oliveira Menezes Joice Neves Reis | 2015 | Brazilian Journal of Microbiology2015，46，4： | 1 |
| 9 | Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats显示文摘 | Helen de Morais Camila P. de Souza Luisa M. da Silva Daniele M. Ferreira Maria Fernanda Werner Roberto Andreatini Joice M. da Cunha Janaina M. Zanoveli | 2014 | Behavioural Brain Research2014，，： | 1 |
| 10 | Characterization of electronic structure and bonding in hydroxyapatite:Zn substitution for Ca显示文摘 | Joice Terra Ming Jiang Ellis D E | 2002 | Philosophical Magazine A2002，82，11： | 1 |
| 11 | Stroke survivors' evalua- tions of a stroke Workbook--based intervention designed to in- crease perceived control over recovery显示文摘 | Joice S Jorhnson M Bonetti D | 2012 | Health Education Journal2012，71，： | 1 |
| 12 | Corrosion inhibition by the cafleine 显示文摘 | Rajendran S Joice M | 2004 | CorrosSci2004，22，8： | 1 |
| 13 | Identification and cate-gorization of technical errors by Observational Clinical Hu-man Reliability Assessment(OCHRA)during laparoscopiccholecystectomy 显示文摘 | Tang B Hanna GB Joice P | 2004 | Arch Surg2004，139，11： | 1 |
| 14 | Modulation of blood-brain barrier permeability by neutrophils:in vitro and in vivo studies显示文摘 | Joice SL Mydeen F Couraud PO | | 0，，： | 1 |
| 15 | Stroke survivors' evaluations of a stroke workbook- based intervention designed to increase perceived control over recovery显示文摘 | Sara Joice Marie Johnston Debbie Bonetti | 2012 | Health Education Journal2012，71，： | 1 |
| 16 | Digital control strategy for four quadrant operation of three phase BLDC motor with load variations 显示文摘 | JOICE C S PARANJOTHI S R KUMAR V J S | 2013 | IEEE Transactions on Industrial Informatics2013，9，2： | 1 |
| 17 | Dechlorination of choloro-organics by a white-rot fungus显示文摘 | Huynh V B Chang H M Joice T W | 1985 | TappiJ1985，68，： | 1 |
| 18 | Sequence determination of human papillomavirus type 6a and assembly of virus-like particles in Saceharomyces cerevisiae 显示文摘 | Hoffman KJ Cook JC Joice JG | 1995 | Virology1995，209，2： | 1 |
| 19 | Antibiotic resistance pattern of motile aeromonads from farm raised fresh water fish 显示文摘 | Hatha M Vivekanandhan A A Julie Joice G | 2005 | International Journal of Food Microbiology2005，98，2： | 1 |
| 20 | Prevalence and incidence of nodding syndrome and other forms of epilepsy in onchocerciasis-endemic areas in northern Uganda after the implementation of onchocerciasis control measures显示文摘Background:Around 2007,a nodding syndrome(NS)epidemic appeared in onchocerciasis-endemic districts of northern Uganda,where ivermeain mass distribution had never been implemented.This study evaluated the effect of community-directed treatment with ivermectin(CDTI)and ground larviciding of rivers initiated after 2009 and 2012 respectively,on the epidemiology of NS and other forms of epilepsy(OFE)in some districts of northern Uganda.Methods:In 2012,a population-based community survey of NS/epilepsy was carried out by the Ugandan Ministry of Health in Kitgum and Pader districts.In August 2017,we conducted a new survey in selected villages of these districts and compared our findings with the 2012 data.In addition,two villages in Moyo distria(where CDTI was ongoing since 1993)served as comparative onchocerciasis-endemic sites in which larviciding had never been implemented.The comparison between 2012 and 2017 prevalence and cumulative incidence were done using the Fisher's and Pearson's Chi-square tests at 95%level of significance.Results:A total of 2138 individuals in 390 households were interviewed.In the seleaed villages of Kitgum and Pader,there was no significant decrease in prevalence of NS and OFE between 2012 and 2017.However,the cumulative incidence of all forms of epilepsy decreased from 1165 to 130 per 100000 persons per year(P=0.002);that of NS decreased from 490 to 43 per 100000 persons per year(P=0.037);and for OFE from 675 to 87 per 100000 persons per year(P=0.024).The median age of affeaed persons(NS and OFE)shifted from 13.5(IQR:11.0-15.0)years in 2012 to 18.0(IQR:15.0-20.3)years in 2017;P<0.001.The age-standardized prevalence of OFE in Moyo in 2017 was 4.6%,similar to 4.5%in Kitgum and Pader.Conclusions:Our findings support the growing evidence of a relationship between infection by Onchocerca volvulus and some types of childhood epilepsy,and suggest that a combination of bi-annual mass distribution of ivermectin and ground larviciding of rivers is an effective strategy to prevent NS and OFE in onchocerciasis-hyperendemic areas. | Nolbert Gumisiriza Frank Mubiru Joseph Nelson Siewe Fodjo Martin Mbonye Kayitale An Hotterbeekx Richard Idro Issa Makumbi Tom Lakwo Bernard Opar Joice Kaducu Joseph Francis Wamala Robert Colebunders | 2020 | Infectious Diseases of Poverty2020，9，2： | 1 |
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