|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 2 | Comparison of Central and Extended Left Pancreatectomy for Lesions of the Pancreatic Neck显示文摘 | Lee M. Ocuin MD Juan M. Sarmiento MD Charles A. Staley MD John R. Galloway MD Colin D. Johnson MD William C. Wood MD David A. Kooby MD | 2008 | Annals of Surgical Oncology2008，，8： | 2 |
| 3 | Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 ( hGLP-1 ) receptor显示文摘 | Teng M Johnson MD Thomas C | 2007 | Bioorg Med Chem Lett2007，17，19： | 1 |
| 4 | Neuromodulation for brain disorders:Challenges and opportunities显示文摘 | Johnson MD Lim HH Netoff TI | 2013 | IEEE Transactions on Biomedical Engineering2013，60，3： | 1 |
| 5 | The American customer satisfaction index:nature,purpose,and findings显示文摘 | Fornell C Johnson MD Anderson EW Cha J Bryant BE | 1996 | The Journal of Mar_ket_ing1996，60，： | 1 |
| 6 | Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine显示文摘 | Steams V Johnson MD Rae JM | 2003 | J Natl Cancer Inst2003，95，23： | 1 |
| 7 | Parosteal lipoma:MR imaging characteristics 显示文摘 | Murphey MD Johnson DL Bhatia PS | 1994 | AJR Am Roentgenol1994，162，： | 1 |
| 8 | Active tamoxifen metabolite plasma concentrations after coadminis- tration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine 显示文摘 | Stearns V Johnson MD Rae JM Morocho A Novielli A Bhargava P | 2003 | J Natl Cancer Inst2003，95，23： | 1 |
| 9 | Genetic risks of intracytoplasmic sperm injection in the treatment of mate infertility :recommendations for genetic counseling and screening 显示文摘 | Johnson MD | 1998 | Fertil Steril1998，70，3： | 1 |
| 10 | 显示文摘 | Johnson MD Merlino G | 1995 | Cell Growth Diff1995，6，6： | 1 |
| 11 | Comparison of large bowel function and calcium balance during soft bran and bran consumption显示文摘 | Hosig KB Shinnick FL Johnson MD | 1996 | Cereal Chem1996，73，： | 1 |
| 12 | Role of insulin - likegrowth factors and the type I insulin - like growth factor receptor inthe estrogen - stimulated proliferation of human breast cancer cells显示文摘 | Stewart AJ Johnson MD May FE | 1990 | J Biol Chem1990，265，21： | 1 |
| 13 | Mechanisms and targets of deep brain stimulation in movement disorders显示文摘 | Johnson MD Miocinovic S McIntyre CC | 2008 | Neuro- therapeutics2008，5，2： | 1 |
| 14 | Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner显示文摘 | Joyce MM Burghardt RC Geisert RD Burghardt JR Hooper RN Ross JW Ashworth MD Johnson GA | | 0，，09： | 1 |
| 15 | The American customer satisfaction index: Nature, purpose, and find- ings 显示文摘 | Fornell C Johnson MD Anderson EW | 1996 | The Journal of Marketing1996，4，60： | 1 |
| 16 | Toll-like re- ceptor 1 polymorphisms increase susceptibility to can- didemia显示文摘 | Plantinga TS Johnson MD Scott WK | 2012 | J Infect Dis2012，205，6： | 1 |
| 17 | Antimicrobial agents in treatment of MRSA infections 显示文摘 | Johnson MD Decker CF | 2008 | Dis Mon2008，54，12： | 1 |
| 18 | Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland显示文摘 | Johnson MD Kenney N Stoica A | 2003 | Nat Med2003，9，8： | 1 |
| 19 | Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury显示文摘 | TANG - SCHOMER MD JOHNSON VE BAAS PW | 2012 | Exp Neurol2012，233，1： | 1 |
| 20 | Herpes simplex virus(aSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection显示文摘 | Johnson AJ Nelson MH Bird MD | 2010 | J Reprod Immunol2010，84，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员