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| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 3 | The role of maladaptive be- liefs in cognitive - behavioral therapy : Evidence from social anxie- ty disorder 显示文摘 | Boden MT John OP Goldin PR | 2012 | Behav Res Ther2012，50，5： | 1 |
| 4 | Changes in demography and demand for services from people with complex needs and profound and multiple learning disabilities 显示文摘 | Richard PR Nigel T John W | 2008 | Tizard Learn Disabil Rev2008，13，3： | 1 |
| 5 | Hypertention secondary to progressive vascular Neurofibromatosis 显示文摘 | Kurien A John PR Milford DV | 1997 | Arch Dis Child1997，76，5： | 1 |
| 6 | The role of maladaptive beliefs in cognitive-behavioral therapy: evidence from social anxiety disorder显示文摘 | Boden MT John OP Goldin PR | 2012 | Behav Res Ther2012，50，： | 1 |
| 7 | Symptomat- ic caval penetration by a Celect inferior vena cava filter 显示文摘 | Bogue CO John PR Conno]ly BL | 2009 | Pediatr Radiol2009，39，10： | 1 |
| 8 | The fuzzy medical group in the centre for computational intelligence显示文摘 | Innocent PR John RI Garibaldi JM | 2001 | Artif Intell Med2001，21，13： | 1 |
| 9 | Marital status, partner satisfac-tion, and depressive symptoms in older men and women 显示文摘 | St John PD Montgomery PR | 2009 | Can J Psychiatry2009，54，7： | 1 |
| 10 | An assessment of the impact of pregnancy on trauma mortality 显示文摘 | John PR Shiozawa A Haut ER | 2011 | Surgery2011，149，： | 1 |
| 11 | Ⅱb's are not Ⅱb's显示文摘 | Dean JK John PR Thomas MB | 2000 | Am J Cardiol2000，85，： | 1 |
| 12 | Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: Clinical outcome显示文摘 | No?lle C. van der Voort van Zyp Jean-Briac Prévost Mischa S. Hoogeman John Praag Bronno van der Holt Peter C. Levendag Robertus J. van Klaveren Peter Pattynama Joost J. Nuyttens | 2009 | Radiotherapy and Oncology2009，，3： | 1 |
| 13 | Gonadectomy prevents endothelial dysfunction in fructose-fedmale rats,a factor contributing to the development of hypertension显示文摘 | Vasudevan H Nagareddy PR John H | 2006 | Am J Physiol Heart Circ Physiol2006，291，6： | 1 |
| 14 | Genome screen for Platelet Monoamine Oxidase (MAO) Activity显示文摘 | John PR Rochberg N | 1999 | American Journal of Medical Genetics1999，88，： | 1 |
| 15 | Outcomes of patients with new-onset di- abets mellitus after liver transplantation compared with those without diabetes mellitus显示文摘 | John PR Thuluvath PJ | 2002 | Liver Transpl2002，8，8： | 1 |
| 16 | Infralabyrinthine approach to skull-base lesions显示文摘 | Lambert PR Johns ME Winn RH | 1985 | Otolaryngol Head Neck Surg1985，93，2： | 1 |
| 17 | Life and death of neurons in the aging brain显示文摘 | John HM Hof PR | 1997 | Science1997，278，5337： | 1 |
| 18 | Improved technique of portal vein reconstruction in pediatric liver transplant re- cipients with portal vein hypoplasia 显示文摘 | Mitchell A John PR Mayer DA | 2002 | Transplantation2002，73，8： | 1 |
| 19 | Growth of adult goldfish eyes, Ⅲ ,source of the new retinal cells 显示文摘 | Johns PR | 1997 | J Comp Neurol1997，176，： | 1 |
| 20 | Social implications of the internet显示文摘 | DIMAGGIO P ESZTER H RUSSELL N JOHN PR | 2001 | Annual Review of Sociolo- gy2001，27，： | 1 |
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