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您的检索式：作者名="John M.Sedivy"
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| 1 | Inflammation,epigenetics,and metabolism converge to cell senescence and ageing:the regulation and intervention显示文摘Remarkable progress in ageing research has been achieved over the past decades.General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing.Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli,representing current hotspots as they not only(re-)shape the individual cell identity,but also involve in cell fate decision.This review focuses on the present findings and emerging concepts in epigenetic,inflammatory,and metabolic regulations and the consequences of the ageing process.Potential therapeutic interventions targeting cell senescence and regulatory mechanisms,using state-of-the-art techniques are also discussed. | Xudong Zhu Zhiyang Chen Weiyan Shen Gang Huang John M.Sedivy Hu Wang Zhenyu Ju | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 2 | L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia显示文摘Dear Editor,Telomere attrition is one of the hallmark of aging.Lategeneration Terc knockout mice exhibit impaired hematopoiesis,1 while the underling mechanisms remain poorly understood.Retrotransposon long interspersed element-1(L1)is the only human retrotransposable elements capable of autonomous retrotransposition,and evolutionarily inactive.Recent studies reported that L1 is derepressed during the aging process with redistribution and reorganization of the heterochromatin.2 Considering that telomere shortening can cause chromosome instability and rearrangements,3 we speculate that L1 may play a role in impaired hematopoiesis in telomere dysfunctional mice. | Ying Wang Jin-ping Zheng Ying Luo Junyi Wang Lingjie Xu Jinyong Wang John M.Sedivy Zhangfa Song Hu Wang Zhenyu Ju | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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