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15篇 您的检索式:作者名="John FS"
    题名 作者 年代 出处 被引量
1Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome.Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel 2006World Journal of Gastroenterology2006,12,39:3
2Impact of 18F fluorodeoxyglucose positron emission tomography on staging and management of early-stage follicular non-Hodgkin lymphoma显示文摘Andrew W Marcus F John FS 2008Int J Radiat Oncol2008,71,1:1
3Bronchial arterial embolization to control hemoptysis: a review显示文摘John FS Mischarl AB 1988Cardiovasc Intervent Radiol1988,11,:1
4The Ecology of Arsenic 显示文摘Ronald SO John FS 2003Science2003,300,9:1
5Interpersonal and personality dimensions of behavior:FIRO-band the big five显示文摘John MM Mark FS 2005North Am J Psych2005,,7:1
6Base excess determined within one hour of admission predicts mortality in patients with se- vere pelvic fractures and severe hemorrhagic shock 显示文摘Abt R Lustenberger T John FS 2009Eur J Trauma Emerg Surg2009,35,5:1
7Induction of Metallothionein by Stress and its Molecular Mechanisms显示文摘Samaon TJ Kalpana G John FS 0,,:1
8Altered protein binding of etoposide in patients eith cancer 显示文摘CLINTON FS PHARM D JOHN A 1989Clin Pharmacol Ther1989,45,:1
9Pulmonary alveolar proteinosis显示文摘John FS Jeffrey JP 2002Am J Respir Crit Care Med2002,166,:1
10Charaelerislies and surgical treatment of doliehoectatic and fusiform aneurysms 显示文摘John AA Michael TL Robert FS 1996J Neurosurgery1996,84,:1
11Concomitant intraoperative splenic artery embolization and laparoscopic splenectomy versus laparoscopic splenectomy:comparison of treatment outcome显示文摘Joseph JN Eric JS John FS 0,,:1
12Giant serpentine extmcranial-intractanial bypass显示文摘Kahl AG John AA Robert FS 1993J Neurosurgery1993,78,:1
13Use of the minimum data set to rate incontinence severity显示文摘Valerie CC John FS Joseph PO 1995Jags1995,43,:1
14Induction of Metallothinein by stress and its moleculor mechanisms显示文摘Samson T J Kalpana G John FS 1999Gene Express1999,7,:1
15Surfactant recovery from water using foam fractionation:effect of temperature and added salt显示文摘Krit K John FS Somchai O 1999Sep Sci Technol1999,34,2:1
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