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| 1 | Advances and prospects of drug clinical research in colorectal cancer in 2022显示文摘Colorectal cancer(CRC)is the third most common cancer and the second leading cause of cancer death worldwide.Clinical research results have provided more treatment opportunities for CRC patients,showing that an optimal combination of existing drugs and new drugs is needed to mitigate the burden of this disease.In this review,we have summarized recent advances in drug clinical research for CRC in 2022,including chemotherapy,targeted therapy,and immunotherapy,to find opportunities for substantial improvements in drug discovery and clinical development methods. | Dan Su Chao Liu Jie Cui Jiebing Tang Yuli Ruan Yanqiao Zhang | 2023 | Cancer Innovation2023，2，2： | 0 |
| 2 | Comparative Analyses and Phylogenetic Relationships between Cryptomeria fortunei and Related Species Based on Complete Chloroplast Genomes显示文摘Cryptomeria fortunei(Chinese cedar)is a highly adaptable woody species and one of the main forest plantation trees in subtropical high-altitude areas in China.However,there are few studies on its chloroplast(cp)genome.In this study,the complete cp genome of C.fortunei was sequenced and evaluated via comparative analyses with those of related species(formerly the Taxodiaceae)in Cupressaceae.The C.fortunei cp genome was 131,580 bp in length,and the GC content of the whole genome was 35.38%.It lost one relevant large inverted repeat and contained 114 unique genes,including 82 protein-coding genes,28 tRNAs and 4 rRNAs.The relative synonymous codon usage(RSCU)of codons ending with A/U was more than twice that of codons ending with G/C.Thirty long repeat structures(LRSs)and 213 simple sequence repeat(SSR)loci were detected in the C.fortunei cp genome.Comparative analyses of 10 cp genomes revealed that substantial rearrangements occurred in the gene organization.Additionally,6 cp hotspot regions(trnS-GGA,ycf1,trnP-GGG,trnC-GCA,psbZ and accD)were identified,and 4 genes(petL,psbM,rpl22 and psaM)had likely underwent positive selection.Phylogenetic analysis showed that Cupressaceae,Taxaceae and Cephalotaxaceae clustered to form a clade and that C.fortunei was most closely related to C.japonica(Japanese cedar),C.japonica cv.Wogon Hort and Taxodium distichum(baldcypress).These results provide references for future studies of population genetics,phylogenetic status and molecular markers among Cupressaceae species and for the cultivation of improved varieties. | Yingting Zhang Junjie Yang Zhenhao Guo Jiaxing Mo Jiebing Cui Hailiang Hu Jin Xu | 2020 | Phyton-International Journal of Experimental Botany2020，89，4： | 0 |
| 3 | Influence of strain rate on grain refinement and texture evolution under complex shear stress conditions显示文摘The effects of different complex shear stress conditions on grain refinement and texture evolution of Mg-13Gd-4Y-2Zn-0.5Zr alloy were investigated.With increasing strain rate,the average grain size of compression-shear(CS)and compression-torsion(CT)samples are decreased,and the grain size of dynamic recrystallization(DRX)grains is also decreased.This is because that the precipitation number ofβphases is increased,and the hindering effect on grain growth can be significantly enhanced.The DRX fractions of CS and CT samples are decreased with increased strain rate.The low DRX fraction at high strain rate is related to the insufficient time for grains to nucleate.The DRX process can be promoted by the PSN mechanism of second phases,and the grain growth can be restricted by the pinning effect.At the same time,the texture strength is enhanced as the strain rate increased.Besides,the kinking degree of lamellar long-period stacking ordered(LPSO)phases is increased.Under complex shear stress conditions,non-basal slip,especially pyramidal slip,is easily activated and the texture is deflected greatly.Compared with the CS samples,CT samples have smaller average grain size,higher DRX fraction,and lower texture strength for a certain strain rate.This is because that the equivalent stress of the CT sample is larger,the stress triaxiality is smaller,so more serious dislocations are piled up near grain boundaries and second phases.At the same time,since CT sample was sheared with torsion,the dislocation movement path can be called“rotational dislocation accumulation”,and the longer distribution path of the CT sample is generated,so more sub-grains and low-angle grain boundaries(LAGBs)are formed.Compared with the CS sample,more huge-angle grain boundaries(HAGBs)and DRX grains are formed from grain boundary to grain interior,so better grain refinement effect is achieved. | Zhaocan Li Guoqin Wu Jianmin Yu Jiebing Wang Jingjing Han Huiyong Cui Zhimin Zhang | 2023 | Journal of Magnesium and Alloys2023，11，7： | 0 |
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