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| 1 | High-efficiency somatic reprogramming induced by intact MII oocytes显示文摘体的原子核能是进由原子转移,房间熔化和抄写因素的表示的一个 pluripotent 状态的 reprogrammed。然而,这些 reprogramming 过程是很低效的,它极大地妨碍了努力阐明内在的分子的机制。这里,我们报导把所有三 reprogramming 方法论的优点合为一个过程的新 reprogramming 策略。我们从积云房间把原子核注入了未经触动的 MII 卵母细胞。后面的激活,开发到胚胎的茎(ES ) 房间衬里的胚囊阶段,和 tetraploid (4N ) 的 80% 重建的胚胎每重建的卵母细胞以 30% 的率被产生。我们也产生了三倍性(3N ) 在进激活的卵母细胞的体的原子核的注射以后的 ES 房间。4N 和 3N ES 房间表示了 pluripotent 标记并且在 vivo 区分了进三胚胎的细菌层的房间类型。而且,所有 ES 房间产生了 histocompatible,在在免疫能力的 B6D2F1 老鼠被嫁接以后的区分的房间,显示出房间从这 reprogramming 策略导出的那 ES 可能为移植担任遗传上定制的纸巾的来源。因此,我们建立了为调查涉及体的 reprogramming 的分子的机制提供一个系统的一个简单、高度有效的 reprogramming 过程。 | Hui Yang Linyu Shi Shenghua Zhang Jiangwei Lin Jing Jiang Jinsong Li | 2010 | Cell Research2010，20，9： | 2 |
| 2 | Fine-tuning of Pd-Rh core-shell catalysts by interstitial hydrogen doping for enhanced methanol oxidation显示文摘Metal catalysts play an important role in the catalytic electrochemical processes and optimization of their performance is usually achieved through alloying with other metal atoms.Doping with interstitial hydrogen atoms is a special but effective way to regulate the electronic structure of host catalysts.Herein we demonstrate the intermixing of Pd and Rh atoms during the hydrogen-doping process of Pd@Rh core-shell nanocubes,forming an alloyed surface in Pd@Rh-H.The catalysts show enhanced performance in electrocatalytic methanol oxidation,as compared to commercial Pt/C and are even better than PdH@Rh core-shell nanocubes.The small structural differences between the two hydride catalysts are revealed by X-ray electron spectroscopy and pair distribution function analysis of electron diffraction.The theoretical calculation results show that Rh in Pd@Rh-H contains more negative charges than Rh in PdH@Rh,indicating more effective charge transfer in Pd@Rh-H.The d-band center(£d)of the Rh site in Pd@Rh-H shifts up,and the synergy between Rh and Pd optimizes the binding energy of CO and OH,inducing preferential catalytic activity.Our work provides guidance for the synthesis of high-performance catalysts by doping with interstitial atoms,which may provide a new strategy to fine-tune the electronic structure of other bimetallic nanoparticles. | Xiaoyun Guo Zheng Hu Jianxin Lv Hui Li Qinghua Zhang Lin Gu Wei Zhou Jiangwei Zhang Shi Hu | 2022 | Nano Research2022，15，2： | 1 |
| 3 | Chip-scale spontaneous quasi-phase matched second harmonic generation in a micro-racetrack resonator显示文摘In this paper,we demonstrate efficient spontaneous quasi-phase matched(SQPM)second harmonic generation(SHG)in a microracetrack resonator on X-cut thin film lithium niobate.Our approach does not involve poling,but exploits the anisotropy of the crystals to allow the phase-matching condition to be fulfilled spontaneously as the TE-polarized light circulates in a specifically designed racetrack resonator.In experiment,normalized on-chip conversion efficiencies of 1.01×10-4/W and 0.43×10-4/W are achieved by 37th-order and 111th-order SQPM,respectively.The configurable SQPM will benefit the application of nonlinear frequency conversion and quantum source generation in chip-scale integrated photonics compatible with standard CMOS fabrication processes. | Tingge Yuan Jiangwei Wu Yi'an Liu Xiongshuo Yan Haowei Jiang Hao Li Zhaokang Liang Qiang Lin Yuping Chen Xianfeng Chen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 1 |
| 4 | Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke显示文摘Ischemic stroke(IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator(r-t PA).Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine(TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates infammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs. | Hanyu Zhang Bowen Jin Xinyu You Pengrong Yi Hong Guo Lin Niu Qingsheng Yin Jiangwei Shi Yanjun Zhang Pengwei Zhuang | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 5 | Different developmental potential of pluripotent stem cells generated by different reprogramming strategies显示文摘Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials. | Jing Jiang Guohui Ding Jiangwei Lin Man Zhang Linyu Shi Wenjian Lv Hui Yang Huasheng Xiao Gang Pei Yixue Li Jiarui Wu Jinsong Li | 2011 | Journal of Molecular Cell Biology2011，3，3： | 0 |
| 6 | Peripheral origin exosomal micro RNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment显示文摘Cognitive dysfunction is one of the common central nervous systems(CNS)complications of diabetes mellitus,which seriously affects the quality of life of patients and results in a huge economic burden.The glymphatic system dysfunction mediated by aquaporin-4(AQP4)loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment(DCI).However,the mechanism of AQP4 loss or redistribution in the diabetic states remains unclear.Accumulating evidence suggests that peripheral insulin resistance target tissues and CNS communication affect brain homeostasis and that exosomal miRNAs are key mediators.Glucose and lipid metabolism disorder is an important pathological feature of diabetes mellitus,and skeletal muscle,liver and adipose tissue are the key target insulin resistance organs.In this review,the changes in exosomal miRNAs induced by peripheral metabolism disorders in diabetes mellitus were systematically reviewed.We focused on exosomal miRNAs that could induce low AQP4 expression and redistribution in perivascular astrocyte endfeet,which could provide an interorgan communication pathway to illustrate the pathogenesis of DCI.Furthermore,the mechanisms of exosome secretion from peripheral insulin resistance target tissue and absorption to the CNS were summarized,which will be beneficial for proposing novel and feasible strategies to optimize DCI prevention and/or treatment in diabetic patients. | Lin Zhang Dongna Li Pengrong Yi Jiangwei Shi Mengqing Guo Qingsheng Yin Dingbin Liu Pengwei Zhuang Yanjun Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 7 | Infectivity of SARS-CoV-2 and protection against reinfection in rats显示文摘DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be infected with the SARS-CoV-2 prototype. Our results showed direct experimental evidence of the infectivity of SARS-CoV-2 infection, subsequent pathogenicity, and protection against reinfection in rats. | Dandan Yu Yanghaopeng Long Ling Xu Jian-Bao Han Jiawei Xi Jianlin Xu Lu-Xiu Yang Xiao-Li Feng Qing-Cui Zou Wang Qu Jiangwei Lin Ming-Hua Li Yong-Gang Yao | 2022 | Zoological Research2022，43，6： | 0 |
| 8 | Porousβ-FeOOH nanotube stabilizing Au single atom for highefficiency nitrogen fixation显示文摘Electrochemical nitrogen reduction reaction(NRR)under ambient conditions is highly desirable to achieve sustainable ammonia(NH3)production via an alternative carbon free strategy.Single-atom catalysts(SACs)with super high atomic utilization and catalytic efficiency exhibit great potential for NRR.Herein,a high-performance NRR SAC is facilely prepared via a simple deposition method to anchor Au single atoms onto porousβ-FeOOH nanotubes.The resulting Au-SA/FeOOH can efficiently drive NRR under ambient conditions,and the NH3 yield reaches as high as 2,860μg·h^(-1)·mg_(Au)^(-1)at-0.4 V vs.reversible hydrogen electrode(RHE)with 14.2%faradaic efficiency,much superior to those of all the reported Au-based electrocatalysts.Systematic investigations demonstrate that the synergy of much enhanced N_(2)adsorption,directional electron export,and mass transfer ability in Au-SA/FeOOH greatly contributes to the superior NRR activity.This work highlights a new insight into the design of high efficient NRR electrocatalysts by combination of porous metal oxide matrix and highly active single-atom sites. | Hao Sun Hua-Qing Yin Wenxiong Shi Lu-Lu Yang Xiang-Wei Guo Hong Lin Jiangwei Zhang Tong-Bu Lu Zhi-Ming Zhang | 2022 | Nano Research2022，15，4： | 0 |
| 9 | 3D printing technology in open living donor nephrectomy显示文摘To the Editor:Thereiscurrentlya serious shortage oforgan sources.Therefore,living donorkidney is a critical source in addition to deceased donor kidney.Open donor nephrectomy is one of the most difficult operations in the field of kidney transplantation,and the core issues are the safety of the donor and the psychological stress to the surgeon,such as trying to minimize the surgical complication to the donor,maximize the success rate,and deal with the high expectation from the recipient. | Jiangwei Zhang Hang Yan Wujun Xue Jin Zheng Xiao Li Lin Hao Ting Guo Ying Wang Xiaoming Ding | 2022 | Chinese Medical Journal2022，135，17： | 0 |
| 10 | Spin-valve magnetoresistance in single-phaseε-Fe2~3N film显示文摘Dear editor,ε-Fe2~3N has been investigated as a potential candidate in spintronics devices[1].With the changing ratio of Fe:N,the magnetic behaviors and the spin transport properties of ε-Fe2~3N can be manipulated[2,3].In particular,the Curie temperatuTe changes from 9 K for ε-Fe2N to 575 K for ε-Fe3N,and the room temperature spin-polarization can be controlled bet ween 0 to 0.5 with different Fe:N ratio[4].Therefore,ε-Fe2~3N provides an advanced platform for the design of spintronics devices such as magnetic tunnel junction or spinbased field effect transistor. | Zhikuo TAO Lilei XU Henan FANG Lin CHEN Jiangwei CHEN | 2019 | Science China(Information Sciences)2019，62，12： | 0 |
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