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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Design of energy-saving adaptive fast- charging control strategy for Li-FePO4 battery module显示文摘 | WAI R J JHUNG S J | 2012 | IET Power Electronics2012，5，9： | 1 |
| 3 | Adsorptive removal of methyl orange and methylene blue from aqueous solution with a metal-organic framework material, iron terephthalate (MOF-235)显示文摘 | Enamul Haque Jong Won Jun Sung Hwa Jhung | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 4 | Carbon-supported pal- ladium-ruthenium catalyst for hydropurifieation of terephthalie acid 显示文摘 | Jhung S H Romanenko A V Lee K H | 2002 | Appl Catal A Gen2002，225，12： | 1 |
| 5 | Porous cobalt(11)-organic frameworks with corrugated walls:Structurally robust gas-sorption materials显示文摘 | HUMPHREY S M CHANG J S JHUNG S H | 2007 | Angew Chem Int Ed2007，46，： | 1 |
| 6 | Effects of reaction conditions in microwave synthesis of nanocrystalline barium titanate显示文摘 | Jhung S H Lee J H | 2004 | Mater Lett2004，58，： | 1 |
| 7 | Low-temperature loading of Cu* speeies over porous metal-organic frameworks(MOFs) and adsorptive desulfurization with Cu *-Loaded MOFs 显示文摘 | Khan N A Jhung S H | 2012 | J Hazard Mater2012，，： | 1 |
| 8 | Adsorptive removal of benzothiophene using porous copper- benzenetricarboxylate loaded with phosphotungstic acid 显示文摘 | Khan N A Jhung S H | 2010 | Fuel Process Technol2010，100，： | 1 |
| 9 | Nanoporous metal - containing nickel phosphates: A class of shape - selective catalyst 显示文摘 | CHANG J S HWANG J S JHUNG S H | 2004 | Angew Chem Int Ed2004，43，21： | 1 |
| 10 | Evaluation and overview of the national electronic injury surveillance systemcooperative adverse drug event surveillance project (NEISS- CADES ) 显示文摘 | Jhung MA Budnitz DS Mendelsohn AB | 2007 | Med Care2007，45，102： | 1 |
| 11 | Effects of reaction eonditiom microwave synthesis of nanoerystalline barinm titanate显示文摘 | Jhung Sung Hwa Lee Jin-Ho Yoon Ji Woong | 2004 | Materials Letters2004，58，： | 1 |
| 12 | Selective formation of SAPO-5 and SAPO-34 molecular sieves with microwave irradiation and hydrothermal heating 显示文摘 | Jhung S H Chang J S Hwang J S | 2003 | Microporous and Mesoporous Materials2003，64，： | 1 |
| 13 | Hydrophobicity and catalytic properties of Ti-MFI zeolitessynthesized by microwave and conventional heating 显示文摘 | Cheng-Hua Xu Taihuan Jin Sung Hwa Jhung | 2006 | Catal Today2006，111，34： | 1 |
| 14 | Round Robin Analysis of Pressurized Thermal Shock for Reactor Pressure Vessel显示文摘 | Myung Jo Jhung Seok Hun Kim Jin Ho lee at al | 2003 | Nuclear Engineering and Design2003，226，： | 1 |
| 15 | Remarkable adsorptive performance of a metal-organic framework vanadium- benzenedicarboxylate (MIL-47) for benzothiophene 显示文摘 | Khan N A Jun J W Jeong J H Jhung S H | 2011 | Chemical Communications2011，47，4： | 1 |
| 16 | High uptakes of CO2 and CH4 in mesoporous metal organic frameworks Mil-100 and Mil-101显示文摘 | Llewellyn Philip L Bourrelly Sandrine Serre Christian Vimont Alexandre Daturi Marco Hamon Lomig de Weireld Guy Chang Jong-San Hong Do-Young Hwang Young Kyu Jhung Sung Hwa Frrey Grrard | 2008 | Langmuir2008，24，： | 1 |
| 17 | Efects of reaction condition microwave synthesis of nanocrystalline barium titanate 显示文摘 | Jhung Sung Hwa Lee Jin-Ho Yoon Ji Woong | 2004 | Materials Letters2004，58，： | 1 |
| 18 | Molecular genetics correlates of P16,CDK4,and PRB immunohistochemistry in glicblastomas显示文摘 | Bums KL Weki K Jhung SL | 1998 | J Neuropathol Exp Neurol1998，57，1： | 1 |
| 19 | Abnormalities of emotional awareness and perception in patients with obsessive–compulsive disorder显示文摘 | Jee In Kang Kee Namkoong Sang Woo Yoo Kyungun Jhung Se Joo Kim | 2012 | Journal of Affective Disorders (-)2012，，2： | 1 |
| 20 | Carbon - supported palladium - ruthenium catalyst for hydropurification of terephthalic acid 显示文摘 | Jhung S H Romanenko A V Lee K H | 2002 | ApplCatalA2002，225，： | 1 |
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