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| 1 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 2 | Biomarkers in triple negative breast cancer:A review显示文摘Breast cancer is an intrinsically heterogeneous disease. In the world about 1 million cases of breast cancer are diagnosed annually and more than 170000 are triplenegative. Characteristic feature of triple negative breast cancer(TNBC) is that it lacks expression of oestrogen,progesterone and human epidermal growth factor receptor-2/neu receptors. They comprise 15%-20% of all breast cancers. We did a systematic review of Pub Med and conference databases to identify studies published on biomarkers in TNBC. We included studies with biomarkers including: Epidermal growth factor receptor,vascular endothelial growth factor,c-Myc,C-kit and basal cytokeratins,Poly(ADP-ribose) polymerase-1,p53,tyrosinase kinases,m-TOR,heat and shock proteins and TOP-2A in TNBC. We also looked for studies published on synthetic lethality and inhibition of angiogenesis,growth,and survival pathways. TNBC is a complex disease subtype with many subclasses. Majority TNBC have a basal-like molecular phenotype by gene expression profiling. Their clinical and pathologic features overlap with hereditary BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive behaviour,poor outcome,and absence of targeted therapies. As the complexity of this disease is being simplified over time new targets are also being discovered for the treatment of this disease. There are many biomarkers in TNBC being used in clinical practice. Biomarkers may be useful as prognostic or predictive indicators as well as suggest possible targets for novel therapies. Many targeted agents are being studied for treatment of TNBC. | Budhi S Yadav Priyanka Chanana Swaty Jhamb | 2015 | World Journal of Clinical Oncology2015，6，6： | 13 |
| 3 | 尿液5种肿瘤标记物联合检测对膀胱癌的诊断价值显示文摘目的探讨尿液中核基质蛋白22(NMP22)、细胞黏附分子44(CD44)、细胞角蛋白20(CK20)、癌胚抗原相关细胞黏附分子1(CEACAM1)、膀胱肿瘤抗原(BTA)5种标记物联合检测对膀胱癌的诊断价值。方法选择膀胱癌患者64例(肿瘤组)、非泌尿系肿瘤患者20例(对照组)。采用ELISA法检测两组尿液样本中NMP22、CD44、CK20、CEACAM1、BTA水平,比较5种肿瘤标记物及其不同组合联合诊断膀胱癌的准确性,并分析不同病理分期、分级患者尿中各肿瘤标记物的敏感度。结果肿瘤组尿液中NMP22、CD44、CK20、CEACAM1、BTA水平高于对照组(P均<0.05)。5种肿瘤标记物比较,NMP22检测膀胱癌的阳性率最高(84.3%),但特异度仅55.0%;结合曲线下面积(AUC),CD44检测的诊断价值最大,敏感度为82.8%,特异度为85.0%,随肿瘤分期升高CEACAM1检测膀胱癌的敏感度逐渐增加;不同病理分级,5种肿瘤标记物的敏感度比较差异无统计学意义。BTA、CD44、CK20联合检测膀胱癌的敏感度为96.8%、特异度为80.0%,AUC为0.905,诊断效能高于其他组合。结论检测尿NMP22、CD44、CK20、CEACAM1、BTA对膀胱癌的诊断具有一定的临床意义,CEACAM1对高分期膀胱癌的敏感度更高,CD44、CK20、BTA联合检测对膀胱癌具有更高的诊断价值。 | 刘莉 杨永姣 龙安安 Jhamb Sunidhi Aravind.D 刘晓强 | 2018 | 山东医药2018，58，10： | 11 |
| 4 | Meningiomas in 2009: controversies and future challenges 显示文摘 | Campbell BA Jhamb A Maguire JA | 2009 | Am J Clin Oncol2009，32，1： | 1 |
| 5 | Serum lactate levels as the predictor of outcome in pediatric septic shock显示文摘 | Jat KR Jhamb U Gupta VK | 2011 | Indian J Crit Care Med2011，15，2： | 1 |
| 6 | Fatigue in patients receiving maintenance dialysis: a review of definitions, meas- ures, and contributing factors显示文摘 | Jhamb M Weisbord SD Steel JL | 2008 | Am J Kidney Dis2008，52，2： | 1 |
| 7 | Determination of the activity of stan- dard anti - tuberculosis drugs against intramaerophage Mycobacterium tuberculosis, in vitro : MGIT 960 as a viable alternative for BACTEC 460显示文摘 | Jhamb SS Goyal A Singh PP | 2014 | Braz J Infect Dis2014，18，3： | 1 |
| 8 | Comparative evaluation of surgical outcome after removal of impacted mandibular third molars using a Piezotome or a conventional handpiece:a prospective study显示文摘 | Goyal M Marya K Jhamb A | 2012 | Br J Oral Maxillofac Surg2012，50，6： | 1 |
| 9 | Fatigue in pa- tients receiving maintenance dialysis: a review of definitions measures ,and contributing factors显示文摘 | JHAMB M WEISBORD SD STEEL JL | 2008 | Am J Kidney Dis2008，52，2： | 1 |
| 10 | Clinical evaluation of papilla reconstruction using subepithelial connective tissue graft 显示文摘 | Kanshik A Pk P Jhamb K Chopra D | 2014 | Journal of Clinical and Diagnostic Research2014，8，9： | 1 |
| 11 | Correlates and outcomes of fatigue among incident dialysis patients显示文摘 | JHAMB M ARGYROPOULOS C STEEL JL | 2009 | Clin J Am Soc Nephrol2009，4，11： | 1 |
| 12 | Bidirectional relationship of hyper- tension with obstructive sleep apnea显示文摘 | Jhamb M Unruh M | 2014 | Curt Opin Pulm Med2014，20，6： | 1 |
| 13 | Meningiomas in 2009: controversieS and future challeges 显示文摘 | Campbell BA Jhamb A Maguire JA | 2009 | Am J Clin Oncol2009，32，1： | 1 |
| 14 | Production of soluble recombinant proteins in Escherichia coli : effects of process conditions and chaperone co-expression on cell growth and productionof xylanase 显示文摘 | Jhamb K Sahoo D K | 2012 | Bioresour Technol2012，123，： | 1 |
| 15 | Clinical and endo- scopic factors predict higher pathologic grades of Barrett dysplasia显示文摘 | Anandasabapathy S Jhamb J Davila M | 2007 | Cancer2007，109，4： | 1 |
| 16 | Shared and specific allergenic and antigenic components in the two sexes of American cockroach-Periplaneta Americana显示文摘 | Chaudhry S Jhamb S Chauhan UP | 1990 | Clin Exp Allergy1990，20，1： | 1 |
| 17 | Fatigue in patients receiving maintenance dialysis:a review of definitions,mea- sures,and contributing factors显示文摘 | Jhamb M Weisbord SD Steel JL | 2008 | Am J Kidney Dis2008，52，2： | 1 |
| 18 | Clinical evaluation of papilla reconstruction using subepithelial connective tissue graft显示文摘 | Kaushik A Pk P Jhamb K | 2014 | J Clin Diagn Res2014，8，9： | 1 |
| 19 | Fatigue in patients receiving maintenance dialysis;a review of definitions, mea- sures, and contributing factors显示文摘 | Jhamb M Weisbord SD Steel JL | 2008 | Am J Kidney Dis2008，52，2： | 1 |
| 20 | Meningiomas in 2009: controversies and future challenges显示文摘 | Campbell BA Jhamb A Maguire JA | 2009 | Am J Clin Oncol2009，32，1： | 1 |
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