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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 3 | Gamma irradiation of HIV-1显示文摘 | Richard A Smith Jesse Ingels John J Lochemes Joseph P Dutkowsky Linda L Pifer | 2001 | Journal of Orthopaedic Research2001，，5： | 2 |
| 4 | Quality of Life after Correc- tive Surgery Pils Early Intraperitoneal Postoperative Chemotherapy for Pseudo Myxoma Peritonaeal: a Prospective Study 显示文摘 | Jess P Sensitives LH Glennie MB | 2008 | Discolon Rec- tum2008，51，6： | 1 |
| 5 | Deep desulfurization of oil refinery streams by extraction with ionic liquids显示文摘 | EBER J WASSERSCHEID P JESS A | 2004 | Green Chemistry2004，6，7： | 1 |
| 6 | Biology,rearing and field release on Guam of Euplectrus a parasituid of the fruit-piercing moth,Eudocoma fullonia显示文摘 | Muniappan R Jesse B Reddy G U P | 2004 | Biocontrol2004，49，： | 1 |
| 7 | Scanning probe microscopy of carbon nanotubes显示文摘 | HUBLER U JESS P LANG H P | 1998 | Carbon1998，36，56： | 1 |
| 8 | The impact of preoper- ative stoma site marking on the incidence of complica- tions, quality of life, and patient ~ s independence 显示文摘 | Benjamin P Ruth I Jesse L | 2012 | Dis Colon Rectum2012，55，7： | 1 |
| 9 | Genome-wide nested asso- ciation mapping of quantitative resistance to northern leaf blight in maize显示文摘 | Jesse A P Peter J B Edward S B | 2011 | PNAS2011，108，17： | 1 |
| 10 | A framework fi)r sustainability science: arenovated IPAT identity 显示文摘 | WAGGONER P E JESSE H A | 2002 | Proceedings of the Na- tional Academy of Sciences USA2002，99，： | 1 |
| 11 | Deep desulfurization of oil refinerystreams by extraction with ionic liquids显示文摘 | Esser J Wasserscheid P Jess A | 2004 | Green chemistry2004，3，2： | 1 |
| 12 | Raw and cooked vegetables,fruits,selected micronutrients,and breast cancer risk:a casecontrol study in Germany 显示文摘 | Adzersen KH Jess P Freivogel KW | 2003 | Nutr Cancer2003，46，2： | 1 |
| 13 | Local thermomechanieal characterization of phase transitions using band excitation atomic force acoustic microscopy with heated probe 显示文摘 | Jesse S Nikiforov M P Germinario L T Kalinin S V | 2008 | Applied Physics Letters2008，93，07： | 1 |
| 14 | Determination of isoflavones in dietary supplements containing soy,red clover and kudzu:Extraction followed by basic or acid hydrolysis显示文摘 | Jesse P | 2006 | Journal of Chromatography A2006，1107，： | 1 |
| 15 | Deep desulfurization of oil refinery streams by extraction with ionic liquids显示文摘 | Esser J Wasserscheid P Jess A | 2004 | Green Chemistry2004，6，7： | 1 |
| 16 | Deep desulfu fization of oil refinery streams by extraction with ionic liquids 显示文摘 | EBER J WASSERSCHEID P JESS A | 2004 | Green Chemistry2004，6，7： | 1 |
| 17 | Deep desulfurization of oll refinery streams by extraction with ionic liquids 显示文摘 | Esser J Wasserscheid P Jess A | 2004 | Green Chemistry2004，6，7： | 1 |
| 18 | Deep desulfurization of oil refinery streams by extraction with ionic liquids显示文摘 | ESSER J WASSERCHEID P JESS A | 2004 | Green Chem2004，6，7： | 1 |
| 19 | Mutual solubility of water and a reservoir fluid at high temperatures and pressures experimental and simulated data显示文摘 | KAREN S PEDERSEN JESS MILTER CLAUS P RAS- MUSSENI | 2001 | Fluid Phase Equilibria2001，189，12： | 1 |
| 20 | Structural and electronic properties of CuSbS2 and CuBiS2: Potential absorber materials for thin-film solar cells显示文摘 | Jesse T R Aron W Pooja M P | 2012 | Physical Chemistry Chemical Physics2012，14，20： | 1 |
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