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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Flexible lid to the p53-binding domain of human Mdm2 : hnplications for p53 regulation 显示文摘 | Mark AM Jennifer JG Mary MS | 2003 | Molecular and Cellular Biology2003，23，23： | 1 |
| 3 | Valuing Customers显示文摘 | Sunil Gupta Donald R Lehmann Jennifer Ames Stuart | 2004 | Journal of Marketing Research2004，，： | 1 |
| 4 | Evidence for the use of vilazodone in the treatment of major depressive disorder 显示文摘 | Jennifer AR Laura AM Falk W | 2012 | Expert OpinPharmacother2012，13，15： | 1 |
| 5 | Influence of hydrostatic pressure and pH on the rate of maillard browning in a glucoselysine 显示文摘 | Vanessa M Hill Dave A Letward Jennifer M Ames | 1996 | Food Chemistry1996，，： | 1 |
| 6 | Application of the Maillard reaction in the food industry显示文摘 | JENNIFER AM | 1998 | Food Chemistry1998，62，4： | 1 |
| 7 | Applications of the Maillard reaction in the food industry显示文摘 | Jennifer M Ames | 1998 | Food Chemistry1998，，： | 1 |
| 8 | Application of the Maillard reaction in the fo od industry显示文摘 | JENNIFER M AMES | 1998 | Food Chemistry1998，62，4： | 1 |
| 9 | Applications of the Maillard reaction in the food industry显示文摘 | Ames Jennifer M | 1998 | Food Chemistry1998，62，4： | 1 |
| 10 | Applications of the Maillard reaction in food industry显示文摘 | Jennifer M Ames | 1998 | Food Chemistry1998，62，4： | 1 |
| 11 | The effect of xylose on the generation of volatiles from heated thiamine显示文摘 | Jennifer M Ames Anton Apriyantono | 1992 | Food Chemisry1992，44，： | 1 |
| 12 | Treatment of massive cerebral in- farction显示文摘 | David P Jennifer AF Stephan AM | 2005 | Gun' Neurol Neurosci Rep2005，5，6： | 1 |
| 13 | Applications of the Maillard reaction in the food industry显示文摘 | Jennifer M. Ames | 1998 | Food Chemistry1998，，4： | 1 |
| 14 | Applications of the Maillard reaction in the food industry显示文摘 | Ames Jennifer | | 0，，： | 1 |
| 15 | EU COST action 919 melanoidins in food and health 显示文摘 | Jennifer M Ames | 2002 | International Congress Series2002，1245，： | 1 |
| 16 | Applications of the Maillard reaction in food industry显示文摘 | Ames Jennifer | 1998 | Food Chemistry1998，62，： | 1 |
| 17 | The effect of xylose on the generation of volatiles from heated thiamine显示文摘 | Jennifer M Ames Anton Apriyantono | 1992 | Food Chemistry1992，44，： | 1 |
| 18 | Development and assessment of an optimized next-generation DNA sequencing approach for the mtgenome using the Illumina MiSeq显示文摘 | Jennifer AM Mitchell MH Kateryna DM | 2014 | Forensic Science International:Genetics2014，13，： | 1 |
| 19 | EU COST action 919 melanoidins in food and health 显示文摘 | Jennifer M Ames | 2002 | International Congress Series2002，1245，： | 1 |
| 20 | Health Literacy and Adolescents : a Framework and Agenda for Future Research显示文摘 | Jennifer AM | 2008 | Health Education Research2008，23，5： | 1 |
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