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| 1 | Treatment of the later stages of Parkinson’s disease – pharmacological approaches now and in the future显示文摘The problems associated with the pharmacological treatment of the later stages of Parkinson’s disease(PD)remain those seen over many years.These centre on a loss of drug effect(‘wearing off’)with disease progression,the occurrence of dyskinesia,notably with L-dopa use and the appearance of non-motor symptoms that are largely refractory to dopaminergic medication.Treatment strategies in late PD have been dominated by the use of drug combinations and the subtle manipulation of drug dosage.However,change is occurring as the understanding of the basis of motor complications and fluctuations and non-motor symptoms improves.New pharmacological options are expanding with the advent of longer acting versions of existing dopaminergic drugs,new drug delivery systems and the introduction of non-dopaminergic agents able to manipulate motor function both within the basal ganglia and in other brain regions.Non-dopaminergic agents are also being investigated for the treatment of dyskinesia and for the relief of non-motor symptoms.However,while therapy continues to improve,the treatment of late stage PD remains problematic with non-motor symptoms dominating the unmet need in this patient group. | Peter Jenner | 2015 | Translational Neurodegeneration2015，4，1： | 8 |
| 2 | Understanding cell death in parkinson’s disease显示文摘 | Peter Jenner C. Warren Olanow | 1998 | Ann Neurol1998，，1： | 2 |
| 3 | Chlorination byproducts in chlorinated cooling water of some European coastal power stations 显示文摘 | JENNER H A TAYLOR C J L DONK V | 1997 | Mar Environ Res1997，43，4： | 1 |
| 4 | Rectal washout eliminates exfoliated malignant cells显示文摘 | Jenner DC de Boer WB | 1998 | Dis Colon Rectum1998，41，11： | 1 |
| 5 | Oxidative DNA damage in the parkinsonian brain:an apparent selective increase in 8-hydroxyguanine levels in substantia nigra显示文摘 | ALAM Z I JENNER A DANIEL S E | 1997 | Neurochem1997，69，3： | 1 |
| 6 | Proteosomal function is impaired in substantia nigra in Parkinson's disease显示文摘 | Jenner P | 2001 | Neurosci Lett2001，297，： | 1 |
| 7 | Starch granule initiation and growth are altered in barly mutant that lack isoamylase activity显示文摘 | Jenner H Carrangis L Fahy B Fincher G B Hylton C Laurie D A Parker M Waite D Wagen S V Verhoeven T Denyer K | 2002 | The Plant Journal2002，31，1： | 1 |
| 8 | Antiparkinsonian and neuroprotective effects of modafinil in the MPTP-treated common marmoset显示文摘 | Zeng BY Smith LA | 2000 | Exp Brain Res2000，133，2： | 1 |
| 9 | Muta- tions in Turnip mosaic virus P3 and cylindrical in- clusion proteins are separately required to over- come two Brassica napus resistance genes显示文摘 | Jenner CE Tomimura K Ohshima K | 2002 | Vi- rology2002，300，1： | 1 |
| 10 | Extracellular accumulation of nitric oxide,hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or LPS-induced activation显示文摘 | McNaught KS Jenner P | 2000 | Biochem Pharmacol2000，60，7： | 1 |
| 11 | Liprotein(a)-cholesterol and coronary hert disease in the froming Heavt Stnolyp显示文摘 | Serman LJ Deluca C Jenner JL | 1999 | Clin Chen1999，45，： | 1 |
| 12 | Controlled high power actuation utilizing Terfenol-D显示文摘 | Aston M G Greenough R D Jenner A G I Metheringham W J Prajapate K | 1997 | Journal of Alloys and Compounds1997，258，12： | 1 |
| 13 | The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease显示文摘 | | 2003 | Parkinsonism Relat Disord2003，9，3： | 1 |
| 14 | The continuous circulation system:An advance in constant pressure drilling显示文摘 | Jenner J W | 2004 | SPE 907022004，，： | 1 |
| 15 | The dual role of the potyvirus P3 protein of Turnip mosaic virus as a symptom and avirulence determinant in brassicas显示文摘 | Jenner CE Wang XW Tomimura K | 2003 | Molecular Plant-Microbe Interactions2003，16，9： | 1 |
| 16 | Oxidative damage in neurodegenerative disease显示文摘 | Jenner P | 1998 | Lancet1998，344，： | 1 |
| 17 | Proteasomal function is impaired in substantia nigra in Parkinson's disease 显示文摘 | MCNAUGHT K S JENNER P | 2001 | Neurosci Lett2001，297，3： | 1 |
| 18 | The transcription factors T-bet and GATA-3 control ahemative pathways of T-cell differentiation through a shared set of target genes显示文摘 | Jenner RG Townsend M J Jackson I | 2009 | Proc Nail Acad Sci U S A2009，106，17： | 1 |
| 19 | Serum free light chains in clinical laboratory diagnostics 显示文摘 | Jenner E | 2014 | Clin Chim Acta2014，427，： | 1 |
| 20 | Nitrite-induced deamination and hypochlorite-induced oxidation of DNA in intact human respiratory tract epithelial cells 显示文摘 | SPENCER J P E WHITEMAN M JENNER A | 2000 | Free Radical Biology and Medicine2000，28，7： | 1 |
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