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| 1 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?显示文摘AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS accuracy.RESULTS Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy. | Carrie Luu Marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose M Pimiento Jacques P Fontaine | 2017 | World Journal of Gastroenterology2017，23，46： | 8 |
| 3 | Blood pressure management in acute stroke显示文摘Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor outcomes.Whether to modulate BP in acute stroke has long been debated.With the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal ischaemia.Published evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic stroke.Here we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit. | Jason P Appleton Nikola Sprigg Philip M Bath | 2016 | Stroke & Vascular Neurology2016，1，2： | 7 |
| 4 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 5 | Definitive ab initio studies of model SN2 reactions CH3X+F-(X=F,Cl,OH,SH,NH2,PH2) 显示文摘 | JASON M G CHAEHO P COX R S | 2003 | Chem Eur J2003，9，： | 1 |
| 6 | Incorporation of polarization into the DIRSIG synthetic image generation model 显示文摘 | Jason P M eyers John R Schott Scott D Brown | 2002 | Proceedings of SPIE(S0277-786X)2002，4816，： | 1 |
| 7 | A study of storage assignmentproblem for an order picking line in a pick-and-pass w are-housing system显示文摘 | JASON C H P WU M H | 2008 | Computers&Industrial Engineering2008，，57： | 1 |
| 8 | Numerical analysis of the noisy Kuramoto-Sivashinsky equation in 2 + 1 dimensions显示文摘 | Drotar Jason T Zhao Y P Lu T M | 1999 | Phys Rev E1999，76，8： | 1 |
| 9 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 10 | Ecological re sponses to UV radiation: interactions between the biological effects of UV on plants and on associated or ganisms 显示文摘 | Nigel D P Jason P M McPherson M | 2012 | Physiologia Plantarum2012，145，4： | 1 |
| 11 | Optimal struc- ture, market dynamism, and the strategy of simple rules显示文摘 | Jason P D Kathleen M E Bingham C B | 2009 | Administrative Science Quarterly2009，54，3： | 1 |
| 12 | Solvent effects on copper nanoparticle growth behavior in AOT reverse micelle Systems显示文摘 | Joanna P C Michael E M Jason B T | 2001 | Phys ChemB2001，105，12： | 1 |
| 13 | Optima/ structure, market dynamism, and the strategy of simple rules 显示文摘 | JASON P D KATHLEEN M E CHRISTOPHER B B | 2009 | Administrative Science Quarterly2009，，9： | 1 |
| 14 | Foundation fieldbus has arrived and is here to stay 显示文摘 | Dan P D | 1998 | Instrumentation Technology1998，，： | 1 |
| 15 | Tagging and searching: Search retrieval effectiveness of folksonomies on the World Wide Web显示文摘 | Jason M P | 2008 | Information Processing & Management2008，44，4： | 1 |
| 16 | The relationship between near-axis hydrothermal cooling and the spreading rate of mi& ocean ridges 显示文摘 | Baker E T Chen Y J Jason P M | 1996 | Earth and Planetary Science Letters1996，142，： | 1 |
| 17 | Asthenosphere flow model of hotspot-ridge interactions:a comparison of Iceland and Kerguelen显示文摘 | Mara M Yale Jason P M | 1998 | EPSL1998，161，： | 1 |
| 18 | Housebold knowledge,attitudes and practices related to pet contact and associated zoonoses in Ontario,Canada显示文摘 | JASON W S L ANDREW S P JAN M S | 2012 | BMC Public Health2012，12，： | 1 |
| 19 | Additive Risk Models for Surviv- al Data With High-Dimensional Covariates显示文摘 | Shuangge M Kosorok R Jason P F | 2006 | Biometrics2006，，3： | 1 |
| 20 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
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