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3篇 您的检索式：作者名="Jason Howitt"

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		题名	作者	年代	出处	被引量
	1	Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity显示文摘Pten controls a signaling axis that is implicated to regulate cell proliferation,growth,survival,migration,and metabolism.The molecular mechanisms underlying the specificity of Pten responses to such diverse cellular functions are currently poorly understood.Herewe report the control of Pten activity and signaling specificity during the cell cycle by Ndfip1 regulation of Pten spatial distribution.Genetic deletion of Ndfip1 resulted in a loss of Pten nuclear compartmentalization and increased cell proliferation,despite cytoplasmic Pten remaining active in regulating PI3K/Akt signaling.Cells lacking nuclear Pten were found to have dysregulated levels of Plk1 and cyclin D1 that could drive cell proliferation.In vivo,transgene expression of Ndfip1 in the developing brain increased nuclear Pten and lengthened the cell cycle of neuronal progenitors,resulting in microencephaly.Our results show that local partitioning of Pten from the cytoplasm to the nucleus represents a key mechanism contributing to the specificity of Pten signaling during cell proliferation.	Jason Howitt Ley-Hian Low Ulrich Putz Anh Doan Jenny Lackovic Choo-Peng Goh Jenny Gunnersen John Silke Seong-Seng Tan	2015	Journal of Molecular Cell Biology2015，7，2：	1
	2	Increased ndfipl in the substantia nigra of parkinsonian brains is associated with elevated iron levels 显示文摘	Jason Howitt Amanda M Gysbers Scott Ayton	2014	Plos One2014，9，87：	1
	3	A novel blueprint for ‘top down’ differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia显示文摘	Michael Herfs Sara O Vargas Yusuke Yamamoto Brooke E Howitt Marisa R Nucci Jason L Hornick Frank D Mckeon Wa Xian Christopher P Crum	2013	J. Pathol2013，，3：	1

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