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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Current state of endohepatology: Diagnosis and treatment of portal hypertension and its complications with endoscopic ultrasound显示文摘The diagnosis and management of cirrhosis and portal hypertension(PH)with its complications including variceal hemorrhage,ascites,and hepatic encephalopathy continues to evolve.Although there are established“standards of care”in liver biopsy and measurement of PH,gastric varices remain an area without a universally accepted therapeutic approach.The concept of“Endo Hepatology”has been used to describe of the applications of endoscopic ultrasound(EUS)to these challenges.EUS-liver biopsy(EUS-LB)offers an alternative to percutaneous and transjuglar liver biopsy without compromising safety or efficacy,and with added advantages including the potential to reduce sampling error by allowing biopsies in both hepatic lobes.Furthermore,EUS-LB can be performed during the same procedure as EUS-guided portal pressure gradient(PPG)measurements,allowing for the collection of valuable diagnostic and prognostic data.EUS-guided PPG measurements provide an appealing alternative to the transjugular approach,with proposed advantages including the ability to directly measure portal vein pressure.In addition,EUS-guided treatment of gastric varices(GV)offers several possible advantages to current therapies.EUS-guided treatment of GV allows detailed assessment of the vascular anatomy,similar efficacy and safety to current therapies,and allows the evaluation of treatment effect through doppler ultrasound visualization.The appropriate selection of patients for these procedures is paramount to ensuring generation of useful clinical data and patient safety. | Sean R Rudnick Jason D Conway Mark W Russo | 2021 | World Journal of Hepatology2021，13，8： | 4 |
| 4 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 5 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 6 | Incorporation of polarization into the DIRSIG synthetic image generation model 显示文摘 | Jason P M eyers John R Schott Scott D Brown | 2002 | Proceedings of SPIE(S0277-786X)2002，4816，： | 1 |
| 7 | Seismic assessment of concentrically braced steel frames with shape memory alloy braces 显示文摘 | JASON M C REGINALD D R | 2007 | Journal of Structural Engineering2007，133，6： | 1 |
| 8 | Mutational analysis of the pullulanase-type debranching enzyme of maize indicates multiple functions in starch metabolism 显示文摘 | Jason R D Christophe C Martha G J | 2003 | Plant Cell2003，15，： | 1 |
| 9 | Comparison of a bacteriophage-delivered DNA vaccineand acommercially available recombinant protein vac-cine against hepatitis B显示文摘 | Jason R C Kathryn Bartley Catherine D J | 2011 | Fems Immunol Med Micro-biol2011，61，： | 1 |
| 10 | 显示文摘 | Jason R Jouet Andrea Warren D David M Rosenberg | 2005 | Chem Mater2005，17，11： | 1 |
| 11 | An atomic-level of melting using femtosecond electron diffraction显示文摘 | BRADLEY J S JASON R D ROBERT E J | 2003 | Science2003，302，21： | 1 |
| 12 | What You Export Matters? 显示文摘 | Hausmann R Jason H Rodrik D | 2005 | Journal of Economic Growth2005，12，1： | 1 |
| 13 | Network Dy- namics and Field Evolution : The Growth of Interorganizational Col- laboration in the Life Sciences 显示文摘 | Powell W W White D R Koput K W Jason O S | 2005 | American Journal of Sociology2005，110，4： | 1 |
| 14 | Returning to the roots of culture:A review and reconceptualisation of safety culture显示文摘 | Jason R Edward D | | 0，，： | 1 |
| 15 | A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 显示文摘 | Jason D F Alexander Y R | 2005 | Nat Immunol2005，6，4： | 1 |
| 16 | Hydrological drivers of wetland vegetation community distribution within Everglades National Park,Florida显示文摘 | Jason Todd M Muneepeerakul R Pumo D | 2010 | Advances in Water Resources2010，33，10： | 1 |
| 17 | Effects of the combination treatment of raloxifene and alendronate on the biomechanical properties of vertebral bone显示文摘 | Tamim D Jason W Susan R | 2011 | J Bone Miner Res2011，26，： | 1 |
| 18 | The effects ofdifferent input excitation on the dynamic characterizationof an automotive shock absorber显示文摘 | Kowalski D Mohan D R Jason R | 2001 | SAE Paper2001，，： | 1 |
| 19 | Use of solid-phase microextraction to detect and quantify gas-phase dicarbonyls in indoor environments显示文摘 | Jason E Ham Wells J R | 2006 | Journal of Chromatography A2006，1131，： | 1 |
| 20 | Toxic activity from cultures of Karlodinium micrum (Gyrodinium galatheanum ) (Dinophyceae)-a dinoflagellate associated with fish mortalities in an estuarine aquaculture facility显示文摘 | Jonathan R D Daniel E T Jason E A | 2002 | Harmful Algae2002，1，： | 1 |
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