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| 1 | Improving genomic predictions by correction of genotypes from genotyping by sequencing in livestock populations显示文摘Background: Genotyping by sequencing(GBS) is a robust method to genotype markers. Many factors can influence the genotyping quality. One is that heterozygous genotypes could be wrongly genotyped as homozygotes,dependent on the genotyping depths. In this study, a method correcting this type of genotyping error was demonstrated. The efficiency of this correction method and its effect on genomic prediction were assessed using simulated data of livestock populations.Results: Chip array(Chip) and four depths of GBS data was simulated. After quality control(call rate ≥ 0.8 and MAF ≥ 0.01), the remaining number of Chip and GBS SNPs were both approximately 7,000, averaged over 10 replicates. GBS genotypes were corrected with the proposed method. The reliability of genomic prediction was calculated using GBS, corrected GBS(GBSc), true genotypes for the GBS loci(GBSr) and Chip data. The results showed that GBSc had higher rates of correct genotype calls and higher correlations with true genotypes than GBS. For genomic prediction, using Chip data resulted in the highest reliability. As the depth increased to 10, the prediction reliabilities using GBS and GBSc data approached those using true GBS data. The reliabilities of genomic prediction using GBSc data were 0.604, 0.672, 0.684 and 0.704 after genomic correction, with the improved values of 0.013, 0.009, 0.006 and 0.001 at depth = 2, 4, 5 and 10, respectively.Conclusions: The current study showed that a correction method for GBS data increased the genotype accuracies and, consequently, improved genomic predictions. These results suggest that a correction of GBS genotype is necessary, especially for the GBS data with low depths. | Xiao Wang Mogens SandΦ Lund Peipei Ma Luc Janss Haja N.Kadarmideen Guosheng Su | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 2 | Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas:twenty-five years'experience in a single center 显示文摘 | Maity A Shu HK Janss A | 2004 | Int J Radiat Oncol Biol Phys2004，58，4： | 1 |
| 3 | Segregation analyses for presence of major genes affecting growth,backfat,and litter size in Dutch Meishan crossbreds显示文摘 | Van Arendonk JA Brascamp EW | 1997 | J Anim Sci1997，75，11： | 1 |
| 4 | Development in waterborne urethane and urethane-acrylate binders显示文摘 | Jansse P L | 1991 | Polymers and Colour Journal1991，181，4287： | 1 |
| 5 | Outcome for children with sup ratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy 显示文摘 | Reddy AT Janss AJ Phillips PC | 2000 | Cancer2000，88，9： | 1 |
| 6 | Job Demands, Perceptions d Eft'oft Reward Fairness and Innovative Wonk Behaviour 显示文摘 | Janss O | 2000 | Jrnal d Occupational and organizational psychology2000，73，3： | 1 |
| 7 | Bayesian statistical analyses for presence of single genes affecting meat quality traits in a crossed pig population显示文摘 | van Arendonk JA Brascamp EW | 1997 | Genetics1997，145，2： | 1 |
| 8 | Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation, and chemotherapy 显示文摘 | Reddy AT Janss A J Phillips PC | 2000 | Cancer2000，88，12： | 1 |
| 9 | Detection of quantitative trait loci for backfat thickness and intramuscular fat content in pigs (Sus scrofa)显示文摘 | Janss LL Rattink AP | 1999 | Genetics1999，152，4： | 1 |
| 10 | High microvessel density in primitive neuroectodermal brain tumors of childhood显示文摘 | Crotzer M A Wiewrodt R Janss A J | 2001 | Neuropediatrics2001，32，2： | 1 |
| 11 | Genetic and phenotypic parameters for conformation and yield traits in three Swiss dairy cattle breeds显示文摘 | de Haas Y Janss L L G Kadarmideen H N | 2007 | Journal of Animal Breeding and Genetics2007，124，1： | 1 |
| 12 | Delayed cyclin B1 expression during the G2 arrest following DNA damage 显示文摘 | Maity A Hwang A Janss A | 1996 | Oncogene1996，13，8： | 1 |
| 13 | Caffeine and staurosporine enhance the cytotoxicity of cisplatin and camptothecin in human brain tumor cell line显示文摘 | JANSS AJ LEVOW C BEMHARD EJ | 1998 | Exp Cell Res1998，243，1： | 1 |
| 14 | Delayed cyclin B1 expression during the G2 arrest following DNA damage显示文摘 | Maity A Hwang A Janss A | 1996 | Oncogene1996，13，8： | 1 |
| 15 | Buckling of steel columns in fire conditions显示文摘 | Minne R | 1981 | Fire Saf1981，4，1： | 1 |
| 16 | Validation of the supine venous pump function test:a new noninvasive tool in the assessment of deep venous insufficiency显示文摘 | Jansse MCH Classen JAHR Woller HH | 1996 | Clin Sci1996，91，： | 1 |
| 17 | Resistance of broiler outbred lines to infection with Salmonella enteritidis显示文摘 | N. M. Bolder L. L. G. Janss F. F. Putirulan J. A. Wagenaar | 2002 | Avian Pathology2002，，6： | 1 |
| 18 | Buckling of steel columns in fire eonditions显示文摘 | Janss J Minne R | 2001 | Fire Safety Journal2001，4，22： | 1 |
| 19 | The Extension of Plastic Design to Steel A52 显示文摘 | Janss J Massonnet C | 1967 | Publication oflABSE1967，，27： | 1 |
| 20 | TrkC expression predictsgood clinical outcome in primitive neuroectodermal brain tumors显示文摘 | Grotzer MA Janss AJ Fung K | 2000 | J Clin Oncol2000，18，5： | 1 |
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