|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | PROSPECTS FOR ADVANCED COAL - FUELED FUEL - CELL POWER - PLANTS显示文摘 | JANSEN D VANDERLAAG PC OUDHUIS ABJ | 1994 | JOURNAL OF POWER SOURCES1994，49，13： | 1 |
| 3 | A genomic perspective on protein tyrosine phosphatases:gene structure,pseudogenes,and genetic disease linkage显示文摘 | Echwald SM Mortensen OH | 2004 | FASEB2004，18，1： | 1 |
| 4 | Effect of positive pressure on venous return in volume-loaded surgical patients 显示文摘 | Van Den Berg PC Jansen JRC Pinsky MR | 2002 | J Appl Physiol2002，92，3： | 1 |
| 5 | High dose of simvastatin normalizes postprandial remnant-like particle response in patients with heterozygous familial hypercholesterolemia显示文摘 | Twickler TB Dallinga-Thie GM de Valk HW Schreuder PC Jansen H Cabezas MC | 2000 | Arterioscler Thromb Vasc Biol2000，20，11： | 1 |
| 6 | Fractionated high-dose-rate bracthyerapy in primary carcinoma of the nasopharynx显示文摘 | Levendag PC Schmitz PI Jansen PP | 1998 | J Clin Oncol1998，16，6： | 1 |
| 7 | Effect of positive pressure on venous return in volume - loaded cardiac surgical patients 显示文摘 | Van den Berg PC Jansen JR Pinsky MR | 2002 | J Appl Physiol2002，92，3： | 1 |
| 8 | Effect of positive pressure on venous return in volume-loaded cardiac surgical patients显示文摘 | van den Berg PC Jansen JR Pinsky MR | 2002 | J Appl Physiol2002，92，3： | 1 |
| 9 | Current perspectives on anfiangiogenesis strategies in the treatment of malignant gliomas显示文摘 | Jansen M De Witt-Hamer PC Witmer AN | 2004 | Brain Res Brain Res Rev2004，45，3： | 1 |
| 10 | Current perspectives on antiangiogenesis strategies in the treatment of malignant显示文摘 | Jansen M de witt Hamer PC witmer AN | 2004 | Brain Research Reviews2004，45，3： | 1 |
| 11 | Fractionated high-doserate bracthyerapy in primary carcinoma of the nasopharynx显示文摘 | Levendag PC Schmitz PI Jansen PP | 1998 | J Clin Oncol1998，16，6： | 1 |
| 12 | Effect of positive pres- sure on venous return in volume - loaded cardiac surgical patients 显示文摘 | van den Berg PC Jansen JR Pinsky MR | 2002 | J Appl Physid2002，92，3： | 1 |
| 13 | Proprioceptive and behavior impairments in individuals with anterior cruciate ligament reconstructed knees显示文摘 | Bonfim TR Jansen PC Barela JA | 2003 | Arch Phys Med Rehabil2003，84，8： | 1 |
| 14 | Stem cell profling by nuclear magnetic resonance spectroscopy 显示文摘 | Jansen JF Shamblott MJ van Zijl PC | 2006 | Magn Reson Med2006，56，： | 1 |
| 15 | Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas显示文摘 | Jansen M de Witt Hamer PC Witmer AN | 2004 | Brain Res Brain Res Rev2004，45，3： | 1 |
| 16 | Effect of positive on venous return in volume-loaded cardiac surgical patients 显示文摘 | Vanden Berg PC Jansen R Pinsky MR | 2002 | J Appl Physial2002，92，3： | 1 |
| 17 | Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas显示文摘 | Jansen M de Witt Hamer PC Witmer AN | 2004 | Brain Res Brain Res Rev2004，45，3： | 1 |
| 18 | Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas显示文摘 | Jansen M de Witt Hamer PC Witmer AN | 2004 | Brain Res Brain Res Rev2004，45，3： | 1 |
| 19 | Epilepsy surgery in tuberous sclerosis:the Dutch experience显示文摘 | Jansen FE Huffelen AC Rijen PC | 2007 | Seizure2007，16，： | 1 |
| 20 | Effects of subfertility cause, smoking and body weight on the success rate of IVF显示文摘 | Lintsen AM Pasker-de Jong PC de Boer EJ Burger CW Jansen CA Braat DD van Leeuwen FE | 2005 | Hum Reprod2005，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员