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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | 显示文摘 | Jansen SR Van Ziel AM Baarsma HA | 2010 | Am J Physiol Lung Cell Mol Physiol2010，299，2： | 1 |
| 3 | Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection 显示文摘 | van de Pol AC Wolfs TF Jansen N J van Loon AM Rossen JW | 2006 | Crit Care2006，10，2： | 1 |
| 4 | Hepatic lipase: a pro-or antiatherogenic protein 显示文摘 | Jansen H Verhoeven AM Eric JG | 2002 | J Lipid Res2002，43，： | 1 |
| 5 | Regulated delayed expression of rfc enhances the immunogenicity and protective efficacy of a heterologous antigen delivered by live attenuated Salmonella enterica vaccines显示文摘 | Kong QK Liu Q Jansen AM | 2010 | Vaccine2010，28，37： | 1 |
| 6 | Instability of short tandem repeats (microsatellites) in human cancers显示文摘 | Wooster R Cleton Jansen AM Collins N | | 0，，： | 1 |
| 7 | Cloning and expression of the gene coding for the transmission blocking target antigen Pfs48/45 of Plasmodium falciparum显示文摘 | Kocken CH Jansen J Kaan AM | 1993 | Mol Biochem Parasitol1993，61，： | 1 |
| 8 | Absence of IHH and retention of FTHrP signalling in enchondromas and central chondrosarcomas 显示文摘 | Rozeman LB Hameetman L Cleton - Jansen AM | 2005 | J Patho12005，205，4： | 1 |
| 9 | Monitorig heparln therapy by the activated partial thromboplastin time: the effect of pre -analytical conditions显示文摘 | Van den Besselaar AM Meeuwisse - Braun J Jansen - Gruter R | 1987 | Thromb& Haemost1987，57，： | 1 |
| 10 | Up - regulation of PTHrP and Bcl -2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma 显示文摘 | Bovee JV van den Broek LJ Cleton -Jansen AM | 2000 | Lab Invest2000，80，12： | 1 |
| 11 | Overexpression of the HER2 oncogene does not play a role in high - grade osteosarcomas 显示文摘 | Anninga JK van de Vijver MJ Cleton - Jansen AM | 2004 | Eur J Cancer2004，40，7： | 1 |
| 12 | Micrometastasis and survival in stage Ⅱ colorectal cancer 显示文摘 | Leifers GJ Cleton Jansen AM Vandeveldec JH | 1998 | Nengl J Med1998，339，4： | 1 |
| 13 | Transcriptional regulation of the T cell antigen receptor zeta subunit : identification of a tissue- restricted premoter显示文摘 | Rellahan BL Jansen JP Weissman AM | 1994 | J Exp Med1994，180，4： | 1 |
| 14 | Sucrose feeding in mouse pregnancy leads to hypertension, and sex-linked obesity and insulin resistance in female offspring显示文摘 | Samuelsson AM Matthews PA Jansen E | 2013 | Front Physiol2013，4，： | 1 |
| 15 | Collagen scaffolds implanted in the palatal mucosa显示文摘 | Jansen RG Kuijpers-Jagtman AM van Kuppevelt TH | 2008 | J Craniofac Surg2008，19，3： | 1 |
| 16 | Estrogen signaling is active in cartilaginous tumors: implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma 显示文摘 | Baelde HJ Cleton -Jansen AM van Beerendonk H | 2005 | Clin Cancer Res2005，11，22： | 1 |
| 17 | Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia:a metaanalysis of transcranial Doppler studies显示文摘 | Sabayan B Jansen S Oleksik AM | 2012 | Ageing Res Rev2012，11，2： | 1 |
| 18 | Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment 显示文摘 | Bovee JV Cleton - Jansen AM Taminiau AH | 2005 | Lancet Oncol2005，6，8： | 1 |
| 19 | Monitoring heparin therapy by the activated partital thromboplastin time the effect of preanylytical conditions 显示文摘 | Van den Besselaar AM Meeuwisse-Braun J Jansen Gruter R | 1987 | Thromb & Haemost1987，57，： | 1 |
| 20 | Micrometastases and survival in stage colorectal cancer显示文摘 | Liefers GJ Cleton Jansen AM Vande Velde CJ | 1998 | N Engl J Med1998，339，4： | 1 |
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