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| 1 | Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease显示文摘AIM To evaluate risk factors for primary sclerosing cholangitis(PSC) recurrence(rPSC) after orthotopic liver transplantation(OLT) in patients with well-preserved colons. METHODS We retrospectively evaluated the medical records of all patients transplanted for PSC in our center between July 1994 and May 2015 and selected 47 with followup of at least 60 mo for further analysis based on strict inclusion and exclusion criteria. rPSC was confirmed by magnetic resonance or endoscopic retrograde cholangiopancreatography and liver biopsy. All patients were evaluated by protocolary pre-OLT colonoscopy with randomized mucosal biopsies. Colonoscopy was repeated annually after OLT. Both organ donors and recipients were human leukocyte antigen(HLA) typed by serological and/or DNA methods. All input data were thoroughly analyzed employing relevant statistical methods.RESULTS Altogether, 31 men and 16 women with a median(range) age of 36(15-68) years at the time of OLT and a median follow-up of 122(60-249) mo were included. rPSC was confirmed in 21/47(44.7%) of patients, a median 63(12-180) mo after transplantation. De novo colitis [rPSC in 11/12, P ≤ 0.05, hazard ratio(HR): 4.02, 95% confidence interval(CI): 1.58-10.98] and history of acute cellular rejection(rPSC in 14/25, P ≤ 0.05; HR: 2.66, 95%CI: 1.03-7.86) showed strong positive associations with rPSC. According to the univariate analysis, overlapping features of autoimmune hepatitis(r PSC in 5/5, P ≤ 0.05) and HLA-DRB1*07 in the donor(r PSC in 10/15, P ≤ 0.05) represent other potential risk factors for rPSC, while the HLA-DRB1*04(rPSC in 0/6, P ≤ 0.05), HLA-DQB1*03(rPSC in 1/11, P ≤ 0.05), and HLA-DQB1*07(rPSC in 0/7, P ≤ 0.05) recipient alleles may have protective roles.CONCLUSION De novo colitis and acute cellular rejection are clinical conditions significantly predisposed towards recurrence of PSC after liver transplantation. | Lukas Bajer Antonij Slavcev Peter Macinga Eva Sticova Jan Brezina Matej Roder Radim Janousek Pavel Trunecka Julius Spicak Pavel Drastich | 2018 | World Journal of Gastroenterology2018，24，43： | 4 |
| 2 | Adverse effects of Wolff-Parkinson-White syndrome with right septal or posteroseptal accessory pathways on cardiac function 显示文摘 | Tomaske M Janousek J ROzek V' | 2008 | Europace2008，10，18： | 1 |
| 3 | Mass casualty triage knowledge of military medical personnel显示文摘 | Janousek JT Jackson DE De Lorenzo RA | | 0，，05： | 1 |
| 4 | Safety of orai propafenone in the treatment ofarrhythmias in infants and children(European retrospective muiticenterstudy) 显示文摘 | Janousek J Paui T | 1998 | Am J Cardioi1998，81，09： | 1 |
| 5 | Three-,6-,and 12-month results of autologous transplantation of mononuclear bone marrow ceils in patients with acute myocardial infarction显示文摘 | Meluzin J Janousek S Mayer J | 2008 | Int J Cardiol2008，128，2： | 1 |
| 6 | Immuno-histchemical study of DNA methylation dynamics during plant devel- opment 显示文摘 | Zluvova J Janousek B Vyskot B | 2001 | J Exp Bot2001，52，365： | 1 |
| 7 | Excitation with phase shifted fields-enhancing evaluation of deep cracks in eddy current testing显示文摘 | Ladislav Janousek Zhenmao Chen Noritaka Yusa | 2005 | NDT & E Int2005，38，6： | 1 |
| 8 | Utilization of two-directional AC current distribution for enhancing sizing ability of electromagnetic nondestructive testing methods显示文摘 | Ladislav Janousek Noritaka Yusa Kenzo Miya | 2006 | NDT & E Int2006，39，7： | 1 |
| 9 | Ductal approaches in mammary diagnostics 显示文摘 | Pavlista D Tesarovc P Janousek M | 2007 | Ceska Gynekol2007，72，3： | 1 |
| 10 | Multiprobe inspection for enhancing sizing ability in eddy current nondestructive testing 显示文摘 | Ladislav Janousek Klara Capova Noritaka Yusa | 2005 | IEEE Transactions on Magnetics2005，44，6： | 1 |
| 11 | Permanent cardiac pacing in children: choosing the optimal pacing site: a multicenter study 显示文摘 | Janousek J van Geldorp IE Krupickova S | 2013 | Circula- tion2013，127，5： | 1 |
| 12 | The effects of external mechanical stimulation on the healing of disphyseal osteotomies fixed by flexible external fixation 显示文摘 | Wolf S Janousek A Pfeil J | 1998 | Clin Biomech1998，13，5： | 1 |
| 13 | Ketogenic diet treatmen/ in adults with refractory epilepsy显示文摘 | Klein P Janousek J Barber A | 2010 | Epilepsy Behav2010，19，： | 1 |
| 14 | Interpretation of whole-rock geochemical data in igneous geochemistry: introducing geochemi- cal data toolkit (GCDkit) 显示文摘 | Janousek V Farrow C M Erban V | 2006 | Journal of Petrology2006，47，6： | 1 |
| 15 | Efficient all solid-state continuous-wave yellow-orange light source 显示文摘 | Janousek J Johansson S Tidemand-Lichtenberg P | 2005 | Optics Express2005，13，4： | 1 |
| 16 | Efficacy and safety of propafenone in congenital junctional ectopic tachycardia显示文摘 | Paul T Reimer A Janousek J | 1992 | J Am Coll Cardiol1992，20，4： | 1 |
| 17 | Safety of oral propaenone in the treatment of arrhythmias in infants and children (Eruopean Retrospective Multicenter Study) 显示文摘 | Janousek J Paul T | 1998 | Am J Cardiol1998，81，9： | 1 |
| 18 | Improved quality of life after treatment of prolonged asystole during breath holding spells with a cardiac pacemaker显示文摘 | Kolterer B Gebauer RA Janousek J | 2015 | Ann Pediatr Cardiol2015，8，2： | 1 |
| 19 | Immunohistchemical study of DNA methylation dynamics during plant development显示文摘 | Janousek B Vyskot B | 2001 | J Exp Bot2001，52，365： | 1 |
| 20 | Diagnostics of stress corrosion and fatigue cracks using benchmark signals显示文摘 | Yusa N Janousek L Chen Zhenmao | | 0，，28： | 1 |
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