|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Entry of hepatitis B and C viruses — recent progress and future impact显示文摘 | Thomas F Baumert Luke Meredith Yi Ni Daniel J Felmlee Jane A McKeating Stephan Urban | 2013 | Current Opinion in Virology2013，，： | 3 |
| 3 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 4 | Phosphorus accecerates the develop-ment of parathyroid hyperplasia and Secondary hyperparathyroidism in rats with renal failure 显示文摘 | Masshi D Jane F Eduardo S | 1996 | Am J Kidney Dis1996，28，： | 1 |
| 5 | Effects of lipids on enzymatic hydrolysis and physical properties of starch 显示文摘 | Ai Y F Hasjim J Jane J L | 2013 | Carbo- hydrate Polymers2013，92，1： | 1 |
| 6 | Effects of lipids on enzymatic hydrolysis and physical properties of starch显示文摘 | Ai Y F Hasjim J Jane J L | 2013 | Carbohydrate Polymers2013，92，1： | 1 |
| 7 | Gas chromatography olfactometry of dairy products 显示文摘 | Jane E F Terry E A | 1998 | Dairy Journal1998，8，3： | 1 |
| 8 | Tea catechins and polyphenols:health effects,metabolism,and antioxidant functions显示文摘 | Jane VH Balz F | 2003 | Food Science and Nutrition2003，43，： | 1 |
| 9 | Antioxidant activity of tea polyphenols in vivo :evi- dence from animal smdies显示文摘 | Balz F Jane VH | 2003 | Nutr2003，133，： | 1 |
| 10 | A photostable pyrethroid显示文摘 | ELLIOTr M FARNHAM A W JANES N F | 1973 | Nature1973，246，5429： | 1 |
| 11 | Hypertension in postmenopausal women显示文摘 | Lima R Wofford M Jane F | 2012 | Curr Hypertens Rep2012，14，3： | 1 |
| 12 | Convergence of normal stem cell and cancer stem cell developmental stage:Implication for differential therapies显示文摘Increased evidence shows that normal stem cells may contribute to cancer development and progression by acting as cancer-initiating cells through their interactions with abnormal environmental elements.We postulate that normal stem cells and cancer stem cells (CSC) possess similar mechanisms of self-renewal and differentiation.CSC can be the key to the elaboration of anti-cancer-based therapy.In this article,we focus on a controversial new theme relating to CSC.Tumorigenesis may have a critical stage characterized as a 'therapeutic window',which can be identified by asso-ciation of molecular,biochemical and biological events.Identifying such a stage can allow the production of more effective therapies (e.g.manipulated stem cells) to treat several cancers.More importantly,confirming the existence of a similar therapeutic window during the conversion of normal stem cells to malignant CSC may lead to targeted therapy specifically against CSC.This conversion information may be derived from investigating the biological behaviour of both normal stem cells and cancerous stem cells.Currently,there is little knowledge about the cellular and molecular mechanisms that govern the initiation and maintenance of CSC.Studies on co-evolution and interdependence of cancer with normal tissues may lead to a useful treatment paradigm of cancer.The crosstalk between normal stem cells and cancer formation may converge developmental stages of different types of stem cells (e.g.normal stem cells,CSC and embryonic stem cells).The differential studies of the convergence may result in novel therapies for treating cancers. | Shengwen Calvin Li Katherine L Lee Jane Luo Jiang F Zhong William G Loudon | 2011 | World Journal of Stem Cells2011，3，9： | 1 |
| 13 | Effects of amylopectin brunch chain length and amylose content on the gelatinization and pasting properties of starch显示文摘 | CHEN Y Y LEE L F | 1999 | Cereal Chemistry1999，76，5： | 1 |
| 14 | Use of Mobility Ratios to Estimate Binding Constants of Ligands to Proteins in Affinity Capillary Electrophoresis 显示文摘 | Jane Kawaoka Gomez F A | 1998 | J Chromatogr B1998，715，： | 1 |
| 15 | Phosphorus stress-induced proteoid roots show altered metablism in Lupinus albus显示文摘 | JANE F J ALLAN D L VANCE C D | 1994 | Plant physiol1994，104，： | 1 |
| 16 | Synthetic Insecticide with a New Order of Activity显示文摘 | ELLIOTT M FARNHAM A W JANES N F | 1974 | Nature1974，248，： | 1 |
| 17 | Bevondblue-Targeting depression in young people显示文摘 | Jane B Karen F | 2002 | Youth Stud Austr2002，21，： | 1 |
| 18 | Sustained delivery by leucine-modified chitosan spray-dried respirable powders 显示文摘 | TRISTAN PL JANE LB EDDIE F | 2009 | Int J Pharm2009，372，12： | 1 |
| 19 | Effects of amylopectin branch chain length and amylose content on the gelatinization and pasting properties of starch显示文摘 | Jane J Chen Y Y Lee L F | 1999 | Cereal Chemistry1999，76，5： | 1 |
| 20 | Polycystic ovary syndrome:Androgens and Hypertension显示文摘 | Reckelhoff Jane F | 2007 | Hypertension2007，49，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员