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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells 显示文摘 | Kucia M Reca R Jala VR | 2005 | Leukemia2005，19，7： | 1 |
| 3 | Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells 显示文摘 | Kucia M Reca R Jala VR | 2005 | Leukemia2005，19，7： | 1 |
| 4 | Leukotrienes and atherosclerosis:new roles for old mediators显示文摘 | Jala V R Haribabu B | 2004 | Trends in Immunology2004，25，6： | 1 |
| 5 | Leukotrienes and atherosclerosis :new roles for old mediators 显示文摘 | JALA V R HARIBABU B | 2004 | TRENDS in Immunology2004，25，6： | 1 |
| 6 | Over expression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase from Bacillus stearothermophilus显示文摘 | Jala R Prakash V Appaji N | 2002 | J Biosci2002，27，： | 1 |
| 7 | Role of leukotriene B4 receptors in the development of atherosclerosis:potential mechanisms显示文摘 | Subbarao K Jala V R Mathis S | 2004 | Arteriosclerosis Thrombosis and Vascular Biology2004，24，2： | 1 |
| 8 | Cytochrome p450 en- zymes as catalysts of metabolism of 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen 显示文摘 | Jalas J R Hecht S S and Murphy S E | 2005 | Chem Res Toxicol2005，18，2： | 1 |
| 9 | Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13显示文摘 | JALAS J R DING X X MURPHY S E | 2003 | Drug Metabolism and Disposition2003，31，10： | 1 |
| 10 | Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells显示文摘 | KUCIA M RECA R JALA V R | 2005 | Leukemia2005，19，： | 1 |
| 11 | Leukotrienes and atherosclerosis: new roles for old mediators显示文摘 | JALA V R HARIBABU B | 2004 | Trends Immunol2004，25，6： | 1 |
| 12 | 显示文摘 | JALA V R HARIBABU B | 2004 | Trends Immunol2004，25，6： | 1 |
| 13 | Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insight into the catalytic mechanism 显示文摘 | Gupta A Jala V R | 2002 | J Biol Chem2002，277，17： | 1 |
| 14 | Cytochrome p450 enzymes as catalysts of metabolism of 4-(methytnitrosamino) 1-(3- pyridyl)- 1-butanone, a tobacco specific carcinogen显示文摘 | Jalas J R Hecht S S Murphy S E | 2005 | Chemical Research in Toxicology2005，18，6： | 1 |
| 15 | beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6显示文摘 | GALLIERA E JALA V R TRENT J O | 2004 | J Biol Chem2004，279，25： | 1 |
| 16 | Bone marrow as a home of heterogenous populations ofnonhematopoietic stem cells 显示文摘 | Kucia M Reca R Jala VR | 2005 | Leukemia2005，19，7： | 1 |
| 17 | Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells显示文摘 | Kucia M Reca R Jala VR | 2005 | Leukemia2005，19，7： | 1 |
| 18 | Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells 显示文摘 | Kucia M Reca R Jala V R | 2005 | Leukemia2005，19，7： | 1 |
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