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| 1 | Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells显示文摘Hydroxyapatite(HA)is a representative substance that induces bone regeneration.Our research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological tool.Polyethylenimine(PEI)was used to coat the EH to develop a gene carrier.To verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron microscopy.The pEH particles were well distributed,while only the EH particles were not distributed and aggregated.Then,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta potentials.As a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD PEI.After verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the cells.As a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/pEH.In conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells. | Myung Chul Lee Hoon Seonwoo Kyoung Je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim Yun-Hoon Choung Pankaj Garg Jong Hoon Chung | 2021 | Bioactive Materials2021，6，9： | 2 |
| 2 | Conceptual Design of Compact Supercritical Water-Cooled Fast Reactor with Thermal Hydraulic Coupling显示文摘 | Jaewoon Yoo Yuki Ishiwatari Yoshiaki Oka | | 0，，： | 1 |
| 3 | Ther-mo-mechanical analysis of supercritical pressure light water-cooled fast reactor fuel rod by FEMAXI-6 code显示文摘 | Jaewoon Yoo Yoshiaki Oka Yuki Ishiwatari | 2006 | Annals Nuclear Energy2006，33，1718： | 1 |
| 4 | Regional Income Convergence: Evidence from a Rapidly Growing Economy 显示文摘 | Koo Jaewoon Young Yong Kim Sangphil Kim | 1998 | Journal of Economic Development1998，23，2： | 1 |
| 5 | ,2004,' Fi - nancial Liberalization and Corporate Investments : Evidence from Korean Firm Data', 显示文摘 | Koo jaewoon and Shin S | 2004 | Asian Economic Journal2004，18，： | 1 |
| 6 | Thermo- Mechanical Analysis of Supercritical Pressure Light Water- Cooled Fast Reactor Fuel Rod by FEMAXI 6 Code显示文摘 | Jaewoon Yoo Yoshiaki Oka Yuki Ishiwatari | 2006 | Annals of Nuclear Energy2006，33，： | 1 |
| 7 | Financial Liberalization and Corporate Investments:Evidence from Korean Firm Data显示文摘 | Jaewoon Koo and Sunwoo Shin | 2004 | Asian Economic Journal2004，，18： | 1 |
| 8 | , 2004,“Financial Liberalization and Corporate Investments: Evidence from Korean Firm Data”, 显示文摘 | Koo jaewoon and Shin S | 2004 | Asian Economic Journal2004，18，： | 1 |
| 9 | Financial Liberalization and Corporate Investments: Evidence from Korean Firm Data 显示文摘 | Jaewoon Koo Sunwoo Shin | 2004 | Asian Economic Journal2004，18，3： | 1 |
| 10 | Factors affecting algal blooms in a man-made lake and prediction using an artificial neural network 显示文摘 | Cho Sohyun Lim Byungjin Jung Jaewoon | 2014 | Measurement2014，，53： | 1 |
| 11 | Numerical investigation of heat transfer in upward flows of supercritical water in circular tubes and tight fuel rod bundles显示文摘 | Jue Yang Yoshiaki Oka Yuki Ishiwatari Jie Liu Jaewoon Yoo | 2006 | Nuclear Engineering and Design2006，，4： | 1 |
| 12 | Conceptual design of compact supercritical water-cooled fast reactor with thermal hydraulic coupling 显示文摘 | Jaewoon Yoo Yuki Ishiwatari Yoshiaki Oka | 2006 | Annals of Nuclear Energy2006，，33： | 1 |
| 13 | The Effect of Financial Liberalization on Firms' Investments in Korea 显示文摘 | Koo Jaewoon and Maeng Kyunghee | 2005 | Journal of Asian Economics2005，，2： | 1 |
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