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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | A randomized controlled comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy显示文摘 | Jacobson GF Autry AM Kirby RS | 2001 | AM J Obstet Gynecol2001，184，7： | 1 |
| 3 | Brain activation during working memory is altered in patients with type I diabetes during hypogly- cemia 显示文摘 | Bolo NR Musen G Jacobson AM | 2011 | Diabetes2011，60，12： | 1 |
| 4 | Basophil recruitment and IL-4 production during human allergen induced late asthma显示文摘 | Nouri-Aria KT Irani AM Jacobson MR | 2001 | J Allergy Clin Immunol2001，108，2： | 1 |
| 5 | Reliability and validityof a diabetes quality - of - life measure for the diabetes control andcomplications trial ( DCCT) 显示文摘 | Jacobson AM Barofsky I Cleary P | 1988 | Diabetes Care1988，11，9： | 1 |
| 6 | Psychosocial therapies in diabetes:report of the psychosocial therapies working group显示文摘 | Jacobson AM Anderson B | 2001 | Diabetes Care2001，24，2： | 1 |
| 7 | Quality of life in patients with diabetes mellitus显示文摘 | Jacobson AM | 1997 | Semin Clin Neuropsychol1997，2，1： | 1 |
| 8 | Non-convulsive status epilepticus : usefulness of clinical features in selecting patients for argent EEG 显示文摘 | Husain AM Horn GJ Jacobson MP | 2003 | J Neurol Neurosurg Psychiatry2003，74，2： | 1 |
| 9 | The effects of type 1 diabetes on cerebral white matter显示文摘 | Weinger K Jacobson AM Musen G | 2008 | Diabetologia2008，51，： | 1 |
| 10 | Impact of diabetes and its treatment on cognitive function among adolescents who participated in the diabetes control and complications trial显示文摘 | Musen G Jacobson AM Ryan CM | 2008 | Diabetes Care2008，31，10： | 1 |
| 11 | Long-term effect of diabetes and its treatment on cognitive function显示文摘 | Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group Jacobson AM Musen G | 2007 | N Engl J Med2007，356，： | 1 |
| 12 | Brain activation during working memory is altered in patients with type 1 diabetes dur- ing hypoglycemia显示文摘 | Bolo NR Musen G Jacobson AM | 2011 | Diabetes2011，60，12： | 1 |
| 13 | Resting-state brain functional connectivity is altered in type 2 diabetes显示文摘 | Musen G Jacobson AM Bolo NR | 2012 | Diabetes2012，61，9： | 1 |
| 14 | Nonconvulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG 显示文摘 | Husain AM Horn GJ Jacobson MP | 2003 | Neurol Neurosurg Psychiatry2003，74，2： | 1 |
| 15 | The evaluation of two measures of quality of life in patients with type 1 and type 2 dlabetes显示文摘 | Jacobson AM Samson JA Grout MD | 1994 | Dia - betesCare1994，17，： | 1 |
| 16 | Basophil Recruitment and I1-4 Production during Human Allergen-induced Late Asthma显示文摘 | NOURI-ARIA KT IRANI AM JACOBSON MR | 2001 | J Allergy Clin Immunol (S0091-6749)2001，108，2： | 1 |
| 17 | The long-term effects ot type 1 diabetes treatment and complications on health-related qualitt of life : a 23 - year follow-up of the Diabetes Control and Complica1 tions/Epidemiology of Diabetes Interventions and Complications co1 hort显示文摘 | Jacobson AM Braffett BH Cleary PA | 2013 | Diabetes Care2013，36，10： | 1 |
| 18 | Psychosocial therapies in diabetes: Report of the psychosoeial therapies working group 显示文摘 | Delamater AM Jacobson AM Anderson B | 2001 | Diabetes Care2001，24，7： | 1 |
| 19 | Psychosocial aspects of diabetic retinopathy显示文摘 | Wulsin LR Jacobson AM Rand LI | 1987 | Diabetes Care1987，10，3： | 1 |
| 20 | Resting-state brain functional connectivity is altered in type 2 diabetes显示文摘 | Musen G Jacobson AM Bolo NR et al | 2012 | Diabetes2012，61，9： | 1 |
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