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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Risk fac- tors or Contact lens bacterial contamination during continuous wear显示文摘 | Szczotka-Flynn LB Bajaksouzian S Jacobs MR | 2009 | Optom Vis Sci2009，86，11： | 1 |
| 3 | Differentiation of colon - ic metaplasia from adenocarcinoma of urinary bladder 显示文摘 | Jacobs LB Brooks JD Epstein JI | 1997 | Hum - pathol1997，28，10： | 1 |
| 4 | Differentiation of colonic metaplasin from adenocarc of urinary bladder 显示文摘 | JACOBS LB BROOKS JD EPSTEIN JJ | 1997 | Hum Pathol1997，128，： | 1 |
| 5 | Risk factors for contact lens bacterial contamination during continuous wear显示文摘 | Szczotka-Flynn LB Bajaksouzian S Jacobs MR | 2009 | Optom Vis Sci2009，86，11： | 1 |
| 6 | Role of dietary magnesium deficiency in the pressor and arrhythmogenic response to epinephrine in the intact dog显示文摘 | Barbarm LB Jacob PV | 1994 | Am heart J1994，127，： | 1 |
| 7 | Role of dietary magnesium deficiency in the pressor and arrhythmogenic response to epinephrine in the intact dog显示文摘 | Barbarn LB Jacob PV | 1994 | Am Heart J1994，127，1： | 1 |
| 8 | Differentitation of colonic metaplasia from adenocarcinoma of urinary bladder显示文摘 | Jacobs LB Brooks JD Epstein JI | 1997 | Hum Pathol1997，28，10： | 1 |
| 9 | Differentitation of colonic meta-plasic from adenocarcinoma of urinary bladder显示文摘 | Jacobs LB Brooks JD Epstein JI | 1997 | Hum Pathol1997，28，10： | 1 |
| 10 | Endovascular repair versus open surgery in patients with ruptured abdominal aortic aneurysms 显示文摘 | Jacob JV Johanna LB | 2006 | J Vasc Surg2006，44，： | 1 |
| 11 | Role of dietary magnesium deficiency in the pressor and arrhythmogenic response to epinephrine in the intact dog 显示文摘 | Barbara LB Jacob PV | 1994 | Amheart J1994，127，： | 1 |
| 12 | Circulating bone morphogenetic protein levels and delayed fracture healing 显示文摘 | Laurens JB Jacob VE Suzanne LB Thunnissen | 2013 | International Orthopaedics2013，37，3： | 1 |
| 13 | 吉兰-巴雷综合征诊治的10个步骤(Diagnosis and management of Guillain-Barrésyndrome in ten steps全译)显示文摘吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床表现和病程多种多样,其诊疗存在一定的复杂性,而目前尚无可用的国际性临床诊疗指南。本文作者撰写了一份适用于全球的GBS诊疗指南,特别是在疾病暴发期间,以期为临床医生提供指导。本指南根据当前文献和专家共识撰写而成,采用10步式结构,以便在临床实践中更好地应用。本文首先介绍了GBS的诊断标准、临床变异和鉴别诊断;其次,通过10个步骤介绍了GBS的早期识别和诊断、收治重症监护室的指征、治疗指征和选择、疾病进展的监测和处理、临床病程和结局的预测,以及并发症和后遗症的处理。 | Sonja E Leonhard Melissa R Mandarakas Francisco AA Gondim Kathleen Bateman Maria LB Ferreira David R Cornblath Pieter A van Doorn Mario E Dourado Richard AC Hughes Badrul Islam Susumu Kusunoki Carlos A Pardo Ricardo Reisin James J Sejvar Nortina Shahrizaila Cristiane Soares Thirugnanam Umapathi 王玉忠 Eppie M Yiu Hugh J Willison Bart C Jacobs | 2023 | 中华诊断学电子杂志2023，11，3： | 0 |
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