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| 1 | Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability 显示文摘 | Tomasiewicz HC Jacobs MM Wilkinson MB | 2012 | Biol Psychiatry2012，72，10： | 1 |
| 2 | Fetal lung mRNA levels of Hox genes are differentially altered by maternal diabetes and butyrate in rats 显示文摘 | Jacobs HC Bogue CW Pinter E | 1998 | Pediatr Res1998，44，1： | 1 |
| 3 | Apoptotic versus proliferative activities in human BPH显示文摘 | Kyprianou N Yu HC Jacobs SC | 1996 | Hum Pathol1996，27，： | 1 |
| 4 | Apoptotic versus proliferative activities in human benign prostatic hyperplasia显示文摘 | Kyprianou N Tu Hc Jacobs SC | 1996 | Hum Pathol1996，27，7： | 1 |
| 5 | Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture显示文摘 | Bogue CW Jacobs HC Dynia DW | 1996 | Am J Physiol1996，271，51： | 1 |
| 6 | Beta-cell function of the pancreas after narcotizing pancreatitis显示文摘 | Buscher HC Jacobs ML Ong GL | 1999 | Dig Surg1999，16，6： | 1 |
| 7 | Beta-cell function of the pancreatic after necrotizing pancreatitis 显示文摘 | Buscher HC Jacobs ML Ong GL | 1999 | Dis Surg1999，16，6： | 1 |
| 8 | Beta-cell function of the pancreas after necrotizing pancreatitis 显示文摘 | Buscher HC Jacobs ML Ong GL | 1999 | Dig Surg1999，16，6： | 1 |
| 9 | Beta-cell function of the pancreatitis after necrotizing pancreatitis显示文摘 | Buscher HC Jacobs ML Ong GL | 1999 | Dis Surg1999，16，： | 1 |
| 10 | Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans显示文摘Background and Aim:Animal studies indicated that systemic ophthalmic acid(OPH)is a biomarker for hepatic glutathione(GSH)homeostasis,an important determinant of liver function.We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol(APAP)challenges during pylorus-preserving pancreaticoduodenectomy(PPPD)or partial hepatectomy(PH).Methods:Nineteen patients undergoing PPPD(n=7,control group)or PH(n=12)were included.APAP(1000 mg)was administered intravenously before resection(first challenge),and six and twelve hours later,with sequential blood sampling during this period.Arterial,hepatic and portal venous blood samples and liver biopsies were taken on three occasions during the first APAP challenge.Plasma and hepatic OPH and GSH levels were quantified,and venous-arterial differences were calculated to study hepatic release.Results:Systemic GSH levels decreased during the course of the APAP challenge in both surgical groups,without notable change in OPH levels.Hepatic GSH and OPH content was not affected within^3 hours after administration of the first APAP dose in patients undergoing PPPD or PH.In this period,net release of OPH by the liver was observed only in patients undergoing PPPD.Conclusions:The drop in circulating GSH levels following APAP administrations,did not result in an increase in plasma OPH in both patients with an intact liver and in those undergoing liver resection.Hepatic content of GSH and OPH was not affected during the first APAP dose.It is uncertain whether hepatic GSH homeostasis was sufficiently challenged in the present study.Relevance for patients:In the present study,plasma OPH seemed not useful as a marker for GSH depletion because APAP administration during liver surgery did not lead to(immediate)GSH depletion or increased OPH levels.Based on stable levels of hepatic GSH,OPH and thiyl radicals during surgery,standard APAP administration seems to be safe in a postoperative care program with regards to GSH homeostasis in this specific population.However,no general statements can be made on the basis of the current experiment,since GSH homeostasis and susceptibility to xenobiotic toxicity are influenced by several metabolic and genetic factors. | Kim MC van Mierlo Simon AWG Dello Mechteld C de Jong Hans MH van Eijk Theo M de Kok Jacob J Briedé Frank G Schaap Steven WM Olde Damink Cornelius HC Dejong | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
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