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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Systematic review and meta-analysis of esophageal cancer in Africa:Epidemiology, risk factors, management and outcomes显示文摘BACKGROUND Esophageal cancer(EC)is associated with a poor prognosis,particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.AIM To provide further understanding of EC in the context of the unique cultural and genetic diversity,and socio-economic challenges faced on the African continent.METHODS We performed a systematic review of studies from Africa to obtain data on epidemiology,risk factors,management and outcomes of EC.A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer,and the Cancer in Sub-Saharan reports.We searched EMBASE,PubMed,Web of Science,and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved.Random effects metaanalyses were used to assess heterogeneity between studies and to obtain odds ratio(OR)of the associations between EC and risk factors;and incidence rate ratios for EC between sexes with their respective 95%confidence intervals(CI).RESULTS The incidence of EC is higher in males than females,except in North Africa where it is similar for both sexes.The highest age-standardized rate is from Malawi(30.3 and 19.4 cases/year/100000 population for males and females,respectively)followed by Kenya(28.7 cases/year/100000 population for both sexes).The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old.Meta-analysis shows a strong association with tobacco(OR 3.15,95%CI:2.83-3.50).There was significant heterogeneity between studies on alcohol consumption(OR 2.28,95%CI:1.94-2.65)and on low socioeconomic status(OR 139,95%CI:1.25-1.54)as risk factors,but these could also contribute to increasing the incidence of EC.The best treatment outcomes were with esophagectomy with survival rates of 76.6%at 3 years,and chemo-radiotherapy with an overall combined survival time of 267.50 d.CONCLUSION Africa has high incidence and mortality rates of EC,with preventable and nonmodifiable risk factors.Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption.Management requires a multidisciplinary approach,and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy. | Akwi W Asombang Nathaniel Chishinga Alick Nkhoma Jackson Chipaila Bright Nsokolo Martha Manda-Mapalo Joao Filipe G Montiero Lewis Banda Kulwinder S Dua | 2019 | World Journal of Gastroenterology2019，25，31： | 9 |
| 3 | microRNAs in cancer management显示文摘 | Yi W Kong David Ferland-McCollough Thomas J Jackson Martin Bushell | 2012 | Lancet Oncology2012，，6： | 3 |
| 4 | Effects of induced or delayed parturition and supplemental dietary fat oncolostrum and milk composition in sows显示文摘 | Jackson J R Hurley W L Easter R A | 1995 | J Anim Sci1995，73，： | 2 |
| 5 | Vascular endothelial growth factor expression in prostate cancer and benign prostatic byterplasia显示文摘 | JACKSON M W BENTEL J M TILLEY W D | 1997 | J Urol1997，157，6： | 2 |
| 6 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 7 | Regional feedbacks among fire, climate, and tropical deforestation显示文摘 | Hoffmann W A Schroeder W Jackson R B | 2003 | J Geophys Res2003，108，23： | 1 |
| 8 | Effects of rosiglitazone and pioglitazone on lipoprotein metabolism in patients with Type 2 diabetes and normal lipids显示文摘 | BRACKENRIDGE A L JACKSON N JEFFERSON W | 2009 | Diabet Med2009，26，5： | 1 |
| 9 | Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents显示文摘 | Sun T Jackson S Haycock J W | 2006 | Journal of Biotechnology2006，122，3： | 1 |
| 10 | A Hierarchical Model of Leisure Constraints 显示文摘 | CRAWFORD D W JACKSON E L GODBEY G | 1991 | Leisure Sciences1991，13，： | 1 |
| 11 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease显示文摘 | Schewertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 12 | Association of low serum concentration of bilirubin with increased risk of coronary artery disease 显示文摘 | Schwertner H A Jackson W G Tolan G | 1994 | Clin Chem1994，40，1： | 1 |
| 13 | Restoring forest landscapes显示文摘 | Maginnis S Jackson W | 2002 | ITTO Tropical Forest Update2002，12，4： | 1 |
| 14 | Wall-to-platform migration in electrothermal atomic absorption spectrometry显示文摘 | Chen G Jackson K W | 2002 | Spectrochimica Acta Part B2002，53，： | 1 |
| 15 | Relationships between flow, self-concept, psychological skills, and performance 显示文摘 | JACKSON S A THOMAS P R MARSH H W | 2001 | Journal of Aoolied Soort Psvcholow2001，13，2： | 1 |
| 16 | Concept mapping as an alternative approach for the analysis of open-ended survey re- sponses显示文摘 | JACKSON K M TROCHIM W M K | 2002 | Organizational Res Methods2002，5，4： | 1 |
| 17 | Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance显示文摘 | JACKSON C J LIU J W CARR P D | 2013 | Proceedings of the National Academy of Sciences2013，110，10： | 1 |
| 18 | Autop formation during variceUa-zoster virus infection following endoplasmic reticulum stress and the unfolded protein response 显示文摘 | Carpente JE Jackson W Benetti L | 2011 | J Virol2011，85，18： | 1 |
| 19 | The permeability of fibrous porous media显示文摘 | JACKSON W G JAMES F D | 1986 | The Canadian Journal of Chemical Engineering1986，64，3： | 1 |
| 20 | Flammabilityproperties of polymer-layered-silicate nanocomposites显示文摘 | Gilman J W Jackson C L Morgan A B | 2000 | ChemMater2000，12，18： | 1 |
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